Forchheim, Germany Clinical Trials

A listing of Forchheim, Germany clinical trials actively recruiting patients volunteers.

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Found 127 clinical trials
Randomized Trial of TAVI vs. SAVR in Patients With Severe Aortic Valve Stenosis at Intermediate Risk of Mortality

Randomized controlled, multi-center trial randomizing patients with symptomatic severe aortic stenosis at low to intermediate operative risk of mortality in a 1:1 fashion to transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR) to test, whether TAVI is non-inferior to SAVR, as measured by all-cause mortality or stroke …

aortic valve replacement
transcatheter aortic valve implantation
aortic valve stenosis
valvular disease
stenosis
Universit tsklinikum Erlangen
 (9.4 away) Contact site
  • 43 views
  • 26 Jan, 2021
  • +87 other locations
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

The purpose of this study is to evaluate the long-term safety and efficacy of pembrolizumab (MK-3475) in participants from previous Merck pembrolizumab-based parent studies who roll-over into this extension study. This study will consist of three phases: 1) First Course Phase, 2) Survival Follow-up Phase or 3) Second Course Phase. …

mk-3475
pembrolizumab
metastasis
major surgery
Universit tsklinikum Erlangen ( Site 2408)
 (8.7 away) Contact site
  • 510 views
  • 17 Jun, 2021
  • +263 other locations
Efficacy and Safety of Nefecon in Patients With Primary IgA (Immunoglobulin A) Nephropathy

The overall aim of the study is to evaluate the efficacy, safety, and tolerability of Nefecon 16 mg per day in the treatment of patients with primary IgAN (Immunoglobulin A nephropathy) at risk of progressing to end-stage renal disease (ESRD), despite maximum tolerated treatment with renin-angiotensin system (RAS) blockade using …

Universitaetsklinikum Erlangen, Medizinisches Klinik 4, Ulmenweg 18
 (8.7 away) Contact site
  • 735 views
  • 26 Jan, 2021
  • +153 other locations
Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017

The understanding of acute lymphoblastic leukemia (ALL) in childhood and adolescence has largely changed due to extensive genetic research in recent years: ALL is now considered to be a very heterogeneous disease group. The leukemia cells present themselves with quite differently activated regulatory mechanisms of the malignant phenotype. The introduction …

cytarabine
cyclophosphamide
residual tumor
lymphoid leukemia
doxorubicin
Universitaets - Kinderklinik
 (8.7 away) Contact site
  • 562 views
  • 26 Jan, 2021
  • +167 other locations
Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction

The primary objective of Part 1 of the study is to determine if BIIB093 improves functional outcome at Day 90 as measured by the modified Rankin Scale (mRS) when compared with placebo in participants with Large Hemispheric Infarction (LHI). The secondary objectives of Part 1 of the study are to …

MRI
glibenclamide
ischemic stroke
infarct
stroke
Research Site
 (9.4 away) Contact site
  • 213 views
  • 16 Jun, 2021
  • +221 other locations
Study to Assess Efficacy and Safety of Cx601 Adult Allogeneic Expanded Adipose-derived Stem Cells (eASC) for the Treatment of Complex Perianal Fistula(s) in Participants With Crohn's Disease (CD)

The purpose of this study is to evaluate the combined remission of complex perianal fistulas, defined as the clinical assessment at Week 24 of closure of all treated external openings that were draining at baseline despite gentle finger compression, and absence of collections greater than (>) 2 centimeter (cm) (in …

adalimumab
remission
infliximab
monoclonal antibodies
certolizumab pegol
Universitatsklinikum Erlangen
 (8.7 away) Contact site
  • 202 views
  • 28 May, 2021
  • +177 other locations
Roll-over Study in Patients With Endogenous Cushing's Syndrome for LCI699

The purpose of this study is the evaluation of long-term safety of osilodrostat in patients who have already received osilodrostat treatment in a previous Global Novartis-sponsored trial and who, based on investigators' judgement, will continue benefiting with its administration.

lci699
Novartis Investigative Site
 (8.7 away) Contact site
  • 12 views
  • 26 Jan, 2021
  • +48 other locations
Randomization of Single vs Multiple Arterial Grafts

The primary hypothesis of ROMA is that in patients undergoing primary isolated non-emergent coronary artery bypass surgery (CABG), the use of two or more arterial grafts compared to a single arterial graft is associated with a reduction in the composite outcome of death from any cause, any stroke, post discharge …

myocardial infarction
bypass surgery
infarct
stroke
revascularisation
University Hospital Erlangen
 (9.4 away) Contact site
  • 125 views
  • 28 May, 2021
  • +56 other locations
Left Atrial Appendage CLOSURE in Patients With Atrial Fibrillation Compared to Medical Therapy

The study goal is to determine the clinical benefit of percutaneous catheter-based left atrial appendage (LAA) closure in patients with non-valvular atrial fibrillation (NVAF) at high risk of stroke (CHA2DS2-VASc Score 2) as well as high risk of bleeding as compared to best medical care (including a [non-vitamin K] oral …

left atrial appendage closure
noac
apixaban
phenprocoumon
rivaroxaban
Universit tsklinikum Erlangen, Medizinische Klinik II - Kardiologie und Angiologie
 (8.7 away) Contact site
  • 13 views
  • 23 Jan, 2021
  • +31 other locations
A Multicenter Randomized Double-Blind Placebo Controlled Induction Study to Evaluate the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Ulcerative Colitis

The objectives of Sub-Study 1 are to evaluate the efficacy, safety, and pharmacokinetics of risankizumab as induction treatment in subjects with moderately to severely active ulcerative colitis (UC), and to identify the appropriate induction dose of risankizumab for further evaluation in Sub-Study 2. The objective of Sub-Study 2 is to …

remission
Universitaetsklinikum Erlangen /ID# 159354
 (8.7 away) Contact site
  • 604 views
  • 16 Jun, 2021
  • +772 other locations