Forchheim, Germany Clinical Trials

A listing of Forchheim, Germany clinical trials actively recruiting patients volunteers.

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Found 129 clinical trials
Preconditioning of Tumor Tumor Microenvironment and the Immune System to Immunotherapy

PROMIT is a single arm phase 2 trial evaluating the clinical activity of immune checkpoint blockade (ICB) after administration of dacarbazine (DTIC) in patients with unresectable or metastatic, BRAF wildtype melanoma with primary resistance to anti-programmed-cell-death-1 (PD-1/PD-L1) or PD-1 plus anti-cytotoxic-T-lymphocyte antigen 4 (CTLA-4) blockade therapy. If the activity is …

University Hospital
 (8.7 away) Contact site
  • 0 views
  • 29 Jan, 2021
  • 1 location
Non-invasive Sacral Nerve Stimulation in Children and Adolescents With Chronic Constipation

The purpose of this study is to assess the efficacy of additional neuromodulation for treatment of chronic constipation in pediatric patients

Friedrich-Alexander-Universit t Erlangen-N rnberg, Pediatric Surgery
 (8.7 away) Contact site
  • 0 views
  • 30 Jan, 2021
  • 1 location
Sacral Nerve Stimulation in Children and Adolescents With Chronic Constipation

The purpose of this study is to assess the efficacy of neuromodulation for treatment of chronic constipation in pediatric patients and evaluate the differences between the invasive and non-invasive approach.

Friedrich-Alexander-Universit t Erlangen-N rnberg, Pediatric Surgery
 (8.7 away) Contact site
  • 0 views
  • 02 Feb, 2021
  • 1 location
Effects of Concurrent HIIT and WB-EMS Exercise on the Cardiometabolic Risk Profile in Obese Individuals

The main purpose of this study is to compare the impact of concurrent high-intensity interval training (HIIT) and whole-body electromyostimulation exercise (WB-EMS) or low-volume conventional strength training (CST) on the cardiometabolic risk profile, overall physical fitness (cardiorespiratory fitness and muscular strength), body composition, inflammatory markers and subjective health outcomes after …

high-intensity interval training
body mass index
Department of Medicine 1, Hector Center for Nutrition, Exercise and Sports, Friedrich-Alexander-University Erlangen-Nuremberg
 (9.5 away) Contact site
  • 5 views
  • 22 Jan, 2021
  • 1 location
Tofacitinib for Reduction of Spinal Inflammation in Patients With Psoriatic ArthritiS PresenTing With Axial InvOlvement

To evaluate the efficacy of Tofacitinib in reducing inflammation in the sacroiliac joints and spine on magnetic resonance imaging (MRI) in patients with active Psoriatic Arthritis (PsA) with axial Involvement (BASDAI [Bath Ankylosing Spondylitis Disease Activity Index] 4 and total backpain 4 despite treatment with NSAIDs plus evidence of active …

spondylitis
ankylosing spondylitis
arthritis
steroidal anti-inflammatory drugs
tofacitinib
Uniklinikum, Med. Klinik 3
 (8.7 away) Contact site
  • 0 views
  • 05 Feb, 2021
  • +18 other locations
A Trial to Evaluate the Safety and Efficacy of CLDN6 CAR-T +/- CLDN6 RNA-LPX

This is a Phase I/IIa, FIH, open-label, multicenter, dose escalation trial with expansion cohorts to evaluate safety and preliminary efficacy of CLDN6 CAR-T +/- CLDN6 RNA-LPX in patients with CLDN6-positive relapsed or refractory advanced solid tumors.

solid tumor
kidney function test
measurable disease
Universit tsklinikum Erlangen - H matologie & Intrinsische Onkologie - Medizinische Klinik 5
 (8.7 away) Contact site
  • 0 views
  • 23 Jun, 2021
  • +5 other locations
Influence of Probiotics on Clinical Parameters the Oral Microbiome and the Immune System During an Orthodontic Treatment in Adult Patients

Orthodontic treatment with fixed appliances can be necessary to correct malocclusions in adolescence or adulthood. It its known that orthodontic treatment induces aseptic pseudo-inflammatory reactions. However, studies could show that an increase of certain inflammatory cytokines during orthodontic treatment correlated with a higher risk of root resorption. Moreover, it has …

Department of Orthodontics and Orofacial Orthopedics
 (8.7 away) Contact site
  • 0 views
  • 26 Jan, 2021
  • 1 location
Exploring the Immune Response to SARS-CoV-2 COVID-19 Vaccines in Patients With Relapsing Multiple Sclerosis (RMS) Treated With Ofatumumab

This study aims to understand whether patients with MS can mount an immune response to SARS-CoV-2 mRNA vaccines when vaccinated either before initiation of ofatumumab treatment or at least 4 weeks after commencing ofatumumab treatment.

relapsing multiple sclerosis
Novartis Investigative Site
 (8.7 away) Contact site
  • 0 views
  • 11 Jul, 2021
  • +6 other locations
EBIO - Enthesitis Biopsy Study

The purpose of this Phase IV study is to determine the effect of secukinumab on total immune cell numbers obtaines by entheseal biopsy in the inflamed human entheses in patients with Psoriatic Arthritis. This is a single arm, single centre, prospective, open label study with secukinumab.

secukinumab
enthesitis
arthritis
University Hospital Erlangen, Department of Internal Medicine 3, Rheumatology and Immunology
 (8.7 away) Contact site
  • 0 views
  • 20 May, 2021
  • 1 location