Forchheim, Germany Clinical Trials

A listing of Forchheim, Germany clinical trials actively recruiting patients volunteers.

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Found 129 clinical trials
Tofacitinib for Reduction of Spinal Inflammation in Patients With Psoriatic ArthritiS PresenTing With Axial InvOlvement

To evaluate the efficacy of Tofacitinib in reducing inflammation in the sacroiliac joints and spine on magnetic resonance imaging (MRI) in patients with active Psoriatic Arthritis (PsA) with axial Involvement (BASDAI [Bath Ankylosing Spondylitis Disease Activity Index] 4 and total backpain 4 despite treatment with NSAIDs plus evidence of active …

steroidal anti-inflammatory drugs
ankylosing spondylitis
Uniklinikum, Med. Klinik 3
 (8.7 away) Contact site
  • 05 Feb, 2021
  • +18 other locations
A Trial to Evaluate the Safety and Efficacy of CLDN6 CAR-T +/- CLDN6 RNA-LPX

This is a Phase I/IIa, FIH, open-label, multicenter, dose escalation trial with expansion cohorts to evaluate safety and preliminary efficacy of CLDN6 CAR-T +/- CLDN6 RNA-LPX in patients with CLDN6-positive relapsed or refractory advanced solid tumors.

measurable disease
kidney function test
solid tumor
Universit tsklinikum Erlangen - H matologie & Intrinsische Onkologie - Medizinische Klinik 5
 (8.7 away) Contact site
  • 23 Jun, 2021
  • +5 other locations
Hyper-Thermia Enhanced Anti-tumor Efficacy of Trabectedin

This trial compares trabectedin alone to trabectedin in combination with regional hyperthermia in patients with high-risk soft tissue sarcoma. The study is designed to demonstrate a significant benefit for sarcoma-therapy by adding regional hyperthermia.

soft tissue sarcoma
neutrophil count
gastrointestinal stromal tumor
cancer chemotherapy
Universit tsklinikum Erlangen
 (8.7 away) Contact site
  • 22 Jan, 2021
  • +6 other locations
Frontline Asciminib Combination in Chronic Phase CML

Adult male and female patients with newly diagnosed Philadelphia chromosome positive (Ph+) and/or BCR-ABL1 positive CML can be included in the study until 3 months after diagnosis. A <4 week pretreatment with hydroxyurea is permitted. Patients treated for <6 weeks with nilotinib 300 mg BID, imatinib 400 mg QD, or …

philadelphia chromosome
imatinib 400 mg
dasatinib 100 mg
Universit tsklinikum Erlangen
 (8.7 away) Contact site
  • 25 Aug, 2021
  • +36 other locations
Tissue K+ in Primary Hyperaldosteronism

Recent human studies found tissue sodium storage in patients with hyperaldosteronism that could be detected non-invasively by 23Na-MRI. Tissue sodium accumulation could be mobilized upon treatment of hyperaldosteronism. Besides, former animal studies applying chemical electrolyte analysis indicate that this aldosterone induced sodium storage might be accompanied by intracellular potassium loss. …

Nephrology Department, University Hospital Erlangen
 (8.7 away) Contact site
  • 27 Jan, 2021
  • +1 other locations
Renal Denervation in Chronic Kidney Disease - RDN-CKD Study

RDN-CKD Study is a prospective, randomized (1:1, central randomization), double-blind (unblinded interventionalist and blinded study team at each center), sham controlled, multicenter feasibility study. The purpose of the RDN-CKD Study is to demonstrate that renal denervation (RDN) effectively reduces 24-h ambulatory BP in 80 patients with chronic kidney disease (CKD) …

Clinical Research Center, Department of Nephrology and Hypertension, University of Erlangen-Nuremberg
 (8.7 away) Contact site
  • 23 Jan, 2021
  • +5 other locations
Organ Preservation in Locally Advanced Rectal Cancer by Radiochemotherapy Followed by Consolidation Chemotherapy.

There is a growing body of evidence that surgery and associated morbidities can be omitted without compromising oncological safety in selected patients who have achieved a clinical complete response after radiochemotherapy. However with standard neoadjuvant treatment regimens the pathological complete response rate lies in the range between 10%-20%, the number …

University Hospital Erlangen
 (9.4 away) Contact site
  • 22 Jan, 2021
  • +3 other locations
Effects of Concurrent HIIT and WB-EMS Exercise on the Cardiometabolic Risk Profile in Obese Individuals

The main purpose of this study is to compare the impact of concurrent high-intensity interval training (HIIT) and whole-body electromyostimulation exercise (WB-EMS) or low-volume conventional strength training (CST) on the cardiometabolic risk profile, overall physical fitness (cardiorespiratory fitness and muscular strength), body composition, inflammatory markers and subjective health outcomes after …

body mass index
high-intensity interval training
Department of Medicine 1, Hector Center for Nutrition, Exercise and Sports, Friedrich-Alexander-University Erlangen-Nuremberg
 (9.5 away) Contact site
  • 22 Jan, 2021
  • 1 location
Radiotherapy With Pembrolizumab in Metastatic HNSCC

Randomized phase II study of immune stimulation with Pembrolizumab and radiotherapy in second line therapy of metastatic head and neck squamous cell carcinoma.

measurable disease
squamous cell carcinoma
metastatic head and neck squamous cell carcinoma
Erlangen, Universit tsklinikum Strahlenklinik
 (8.7 away) Contact site
  • 26 Jan, 2021
  • +16 other locations
International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013)

The HIT-HGG-2013 trial offers an innovative high-quality diagnostics and science program for children and adolescents >3 years, suffering from one of the following types of high grade gliomas glioblastoma WHO grade IV (GBM) diffuse midlineglioma histone 3 K27M mutated WHO grade IV (DMG) anaplastic astrocytoma WHO grade III (AA) diffuse …

malignant glioma
anaplastic astrocytoma
glioblastoma multiforme
Universit tsklinikum Erlangen
 (8.7 away) Contact site
  • 30 Jan, 2021
  • +48 other locations