Forchheim, Germany Clinical Trials

A listing of Forchheim, Germany clinical trials actively recruiting patients volunteers.

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Found 46 clinical trials
Safety and Efficacy Study of Pembrolizumab (MK-3475) Combined With Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Advance Melanoma (MK-7902-003/E7080-G000-312/LEAP-003)

The purpose of this study is to assess the safety and efficacy of pembrolizumab (MK-3475) combined with lenvatinib (MK-7902/E7080) compared to pembrolizumab alone (with placebo for lenvatinib) as first-line treatment in adults with no prior systemic therapy for their advanced melanoma. The primary study hypotheses are that: 1) The combination …

interferon
cancer
measurable disease
ct scan
solid tumour
Universitaetsklinikum Erlangen ( Site 0044)
 (8.7 away) Contact site
  • 150 views
  • 18 Jun, 2021
  • +125 other locations
International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma

Primary objectives: Randomization R1, all patients eligible: To examine, whether the cumulative incidence of relapses with involvement of the CNS (CNS relapse, pCICR) can be decreased by a modified induction therapy including dexamethasone (experimental arm) instead of prednisone (standard arm) Randomization R2, only patients with high risk LBL eligible: to …

Universit tsklinikum Erlangen, Klinik f r Kinder- und Jugendmedizin, P diatrische Onkologie / H matologie
 (8.7 away) Contact site
  • 0 views
  • 19 Jun, 2021
  • +223 other locations
Study of Efficacy and Safety of Ligelizumab in Chronic Spontaneous Urticaria Patients Who Completed a Previous Study With Ligelizumab

The purpose of this extension study is to establish efficacy and safety of ligelizumab. This will be assessed in adult and adolescent chronic spontaneous urticaria (CSU) patients who have completed a preceding ligelizumab study and have relapsed, following treatment in these preceding studies, despite standard of care H1-antihistamine (H1-AH) treatment. …

antihistamines
urticaria
ligelizumab
Novartis Investigative Site
 (8.7 away) Contact site
  • 0 views
  • 15 Jun, 2021
  • +215 other locations
Study Assessing the Efficacy and Safety of Alpelisib + Nab-paclitaxel in Subjects With Advanced TNBC Who Carry Either a PIK3CA Mutation or Have PTEN Loss Without PIK3CA Mutation

The purpose of this study is to determine whether treatment with alpelisib in combination with nab-paclitaxel is safe and effective in subjects with advanced triple negative breast cancer (aTNBC) who carry either a PIK3CA mutation (Study Part A) or have PTEN loss without PIK3CA mutation (Study Parts B1 and B2)

cancer
measurable disease
metastasis
PTEN
PIK3CA
Novartis Investigative Site
 (8.7 away) Contact site
  • 5 views
  • 02 Jun, 2021
  • +135 other locations
Study to Assess Efficacy and Safety of Cx601 Adult Allogeneic Expanded Adipose-derived Stem Cells (eASC) for the Treatment of Complex Perianal Fistula(s) in Participants With Crohn's Disease (CD)

The purpose of this study is to evaluate the combined remission of complex perianal fistulas, defined as the clinical assessment at Week 24 of closure of all treated external openings that were draining at baseline despite gentle finger compression, and absence of collections greater than (>) 2 centimeter (cm) (in …

crohn's disease
mercaptopurine
luminal
monoclonal antibodies
tumour necrosis
Universitatsklinikum Erlangen
 (8.7 away) Contact site
  • 202 views
  • 28 May, 2021
  • +177 other locations
Treatment Protocol of the NHL-BFM and the NOPHO Study Groups for Mature Aggressive B-cell Lymphoma and Leukemia in Children and Adolescents

The trial B-NHL 2013 is a collaborative prospective, multi-national, multi-center, randomized trial with participating centers of the NHL-BFM group (Austria, Switzerland, Czech Republic, Germany) and the Scandinavian NOPHO group (Denmark, Finland, Norway, Sweden). The aim of the trial is to evaluate the role of rituximab in the treatment of mature …

Universit tsklinikum Erlangen, Klinik f r Kinder- und Jugendmedizin, P diatrische Onkologie / H matologie
 (8.7 away) Contact site
  • 494 views
  • 16 Jun, 2021
  • +92 other locations
A Study of the Efficacy and Safety of Upadacitnib (ABT-494) in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biologic Therapies

The objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo as induction therapy in participants with moderately and severely active Crohn's disease (CD).

endoscopy
mucosal inflammation
crohn's disease
corticosteroids
abdominal pain
Universitaetsklinikum Erlangen /ID# 203552
 (8.7 away) Contact site
  • 824 views
  • 02 Jun, 2021
  • +730 other locations
Efficacy and Safety of 177Lu-edotreotide PRRT in GEP-NET Patients

The purpose of the study is to evaluate efficacy and safety of Peptide Receptor Radionuclide Therapy (PRRT) with 177Lu-Edotreotide compared to targeted molecular therapy with Everolimus in patients with inoperable, progressive, somatostatin receptor-positive (SSTR+), neuroendocrine tumours of gastroenteric or pancreatic origin (GEP-NET).

everolimus
progressive disease
radionuclide therapy
measurable disease
somatostatin
Universit tsklinikum Erlangen
 (8.7 away) Contact site
  • 220 views
  • 19 Apr, 2021
  • +82 other locations
Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients

The purpose of this study is to compare the efficacy and safety of eflornithine in combination with lomustine, compared to lomustine taken alone, in treating patients whose anaplastic astrocytoma has recurred/progressed after radiation and temozolomide chemotherapy.

MRI
tumor progression
astrocytoma
astrocytoma, anaplastic
lomustine
Universtaetsklinikum Erlangen - Neurologische Klinik
 (8.7 away) Contact site
  • 0 views
  • 25 May, 2021
  • +119 other locations
Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction

The primary objective of Part 1 of the study is to determine if BIIB093 improves functional outcome at Day 90 as measured by the modified Rankin Scale (mRS) when compared with placebo in participants with Large Hemispheric Infarction (LHI). The secondary objectives of Part 1 of the study are to …

MRI
infarct
glibenclamide
thrombectomy
ischemic stroke
Research Site
 (9.4 away) Contact site
  • 213 views
  • 16 Jun, 2021
  • +221 other locations