Cologne, Germany Clinical Trials

A listing of Cologne, Germany clinical trials actively recruiting patients volunteers.

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Found 90 clinical trials
A Study Comparing JNJ-68284528 a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA) Versus Pomalidomide Bortezomib and Dexamethasone (PVd) or Daratumumab Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma

The purpose of this study is to compare the efficacy of JNJ-68284528 with standard therapy, either Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd).

measurable disease
immunomodulatory imide drug
platelet count
proteasome inhibitor
Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman
 (64.3 away) Contact site
  • 04 Aug, 2021
  • +104 other locations
Assessing the Impact of Lipoprotein (a) Lowering With TQJ230 on Major Cardiovascular Events in Patients With CVD

This is a pivotal phase 3 study designed to support an indication for the reduction of cardiovascular risk in patients with established CVD and elevated Lp(a)

Novartis Investigative Site
 (1.9 away) Contact site
  • 04 Aug, 2021
  • +547 other locations
Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With a History of Frequent Exacerbations

Phase 3 study to evaluate the efficacy and safety of a benralizumab in patients with moderate to very severe COPD with a history of frequent COPD exacerbations and elevated peripheral blood eosinophils (300/L). Eligible patients must have a history of 2 moderate and/or severe COPD exacerbations in the previous year …

severe chronic obstructive pulmonary disease
eosinophil count
Research Site
 (5.6 away) Contact site
  • 04 Aug, 2021
  • +426 other locations
Efficacy and Safety Study of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low Low or Intermediate Risk Myelodysplastic Syndromes (MDS) in ESA Na ve Subjects Who Require Red Blood Cell Transfusions

The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements. This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept (ACE-536) …

blood transfusion
bone marrow procedure
rzte f. Innere Medizin Gemeinschaftspraxis f. Hamatologie u. Onkologie
 (1.2 away) Contact site
  • 04 Aug, 2021
  • +258 other locations
A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (LEAP-010) (MK-7902-010)

This is a study of pembrolizumab (MK-3475) with or without lenvatinib (E7080/MK-7902) as a first line intervention in a PD-L1 selected population with participants with recurrent or metastatic head and neck squamous cell carcinoma. Hypotheses include: Pembrolizumab + lenvatinib is superior to pembrolizumab + placebo with respect to Objective Response …

measurable disease
primary tumor
squamous cell carcinoma
Universitaetsklinikum Koeln ( Site 2111)
 (2.8 away) Contact site
  • 04 Aug, 2021
  • +146 other locations
Ferumoxtran-10-enhanced MRI in Prostate Cancer Patients

This will be a confirmatory, prospective, open-label, single-arm, reader-blinded, multi-centre phase 3 study to assess the diagnostic accuracy and safety of Ferrotran-enhanced MRI in comparison to unenhanced MRI in the detection of pelvic lymph node metastases in newly-diagnosed adult patients with prostate cancer and an intermediate to high risk for …

adenocarcinoma of prostate
multiparametric magnetic resonance imaging
radical prostatectomy
Universit tsklinikum K ln
 (2.8 away) Contact site
  • 28 May, 2021
  • +13 other locations
International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013)

The HIT-HGG-2013 trial offers an innovative high-quality diagnostics and science program for children and adolescents >3 years, suffering from one of the following types of high grade gliomas glioblastoma WHO grade IV (GBM) diffuse midlineglioma histone 3 K27M mutated WHO grade IV (DMG) anaplastic astrocytoma WHO grade III (AA) diffuse …

malignant glioma
anaplastic astrocytoma
ASKLEPIOS Klinik St. Augustin
 (15.2 away) Contact site
  • 30 Jan, 2021
  • +48 other locations
Trial Evaluating the Safety of 2 Schedules of Cabazitaxel in Elderly Men With mCRPC Previously Treated With a Docetaxel

The purpose of this study is to evaluate the incidence of grade 3 neutropenia and/or neutropenic complications (febrile neutropenia, neutropenic infection) with two schedules of cabazitaxel (bi-weekly versus tri-weekly) plus prednisone in elderly men ( 65 years) with mCRPC previously treated with a docetaxel-containing regimen.

platelet count
surgical castration
progressive disease
Urologie und Kinderurologie Marienkrankenhaus Bergisch
 (9.7 away) Contact site
  • 23 Jan, 2021
  • +53 other locations
Efficacy of Secukinumab Compared to Ustekinumab in Adults With Active Psoriatic Arthritis and Failure of TNF -Inhibitor Treatment

The purpose of this study is to compare the safety and efficacy of secukinumab and ustekinumab in patients with active psoriatic arthritis who showed failure to previous TNF-inhibitor treatment

rheumatoid factor
anti-rheumatic drugs
tumor necrosis factor
plaque psoriasis
Novartis Investigative Site
 (2.8 away) Contact site
  • 21 Jul, 2021
  • +26 other locations
Esomeprazole Moxifloxacin and Amoxicilin for Rescue Therapy of Helicobacter Pylori Infection

Successful H. pylori eradication therapy remains a challenge in medical practice. Despite promising data for first-line, second-line and rescue treatment options based on clinical trials as well as guidelines and expert recommendations, success rates can often not be reproduced in general practice. Rescue options for patients with failed initial or …

Gastroenterologist, private praxis
 (3.4 away) Contact site
  • 07 Nov, 2020
  • 1 location