Cologne, Germany Clinical Trials

A listing of Cologne, Germany clinical trials actively recruiting patients volunteers.

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Found 93 clinical trials
Tisagenlecleucel in Adult Patients With Aggressive B-cell Non-Hodgkin Lymphoma

This is a randomized, open label, multicenter phase III trial comparing the efficacy, safety, and tolerability of tisagenlecleucel to Standard Of Care in adult patients with aggressive B-cell Non-Hodgkin Lymphoma after failure of rituximab and anthracycline containing frontline immunochemotherapy.

high dose chemotherapy
autologous hematopoietic stem cell transplant
fludarabine
b-cell lymphoma
anthracyclines
Novartis Investigative Site
 (2.8 away) Contact site
  • 48 views
  • 19 Jun, 2021
  • +73 other locations
Study Comparing Zanubrutinib + Rituximab Versus Bendamustine + Rituximab in Participants With Untreated Mantle Cell Lymphoma

This is a randomized study to compare the efficacy and safety of zanubrutinib plus rituximab versus bendamustine plus rituximab in previously untreated participants with mantle cell lymphoma (MCL) who are not eligible for stem cell transplantation.

Universit tsklinikum K ln
 (2.8 away) Contact site
  • 40 views
  • 16 May, 2021
  • +118 other locations
PREvention of STroke in Intracerebral haemorrhaGE Survivors With Atrial Fibrillation

Atrial fibrillation (AF) is the most common form of irregular heart rhythm. In people with AF, blood clots often form in the heart, which can travel to the brain. Blockage of brain arteries by these clots is a major cause of stroke. This type of stroke is called an ischaemic …

warfarin
apixaban oral tablet
apixaban
stroke
vascular disease
University Hospital Cologne
 (2.8 away) Contact site
  • 13 views
  • 25 Feb, 2021
  • +27 other locations
A Study of Apalutamide in Participants With High-Risk Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy

The purpose of this study is to determine if treatment with apalutamide plus androgen deprivation therapy (ADT) before and after radical prostatectomy (RP) with pelvic lymph node dissection (pLND) in participants with high-risk localized or locally advanced prostate cancer results in an improvement in pathological complete response (pCR) rate and …

prostatectomy
adenocarcinoma of prostate
androgens
apalutamide
metastasis
Universitaetsklinikum Koeln
 (2.8 away) Contact site
  • 291 views
  • 02 Jun, 2021
  • +352 other locations
Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma

The primary objective of the study is to compare disease-free survival (DFS) of patients with high-risk cutaneous squamous cell carcinoma (CSCC) treated with adjuvant cemiplimab, versus those treated with placebo, after surgery and radiation therapy (RT). The secondary objectives of the study are: To compare the overall survival (OS) of …

metastasis
cemiplimab
Regeneron Research Site
 (2.8 away) Contact site
  • 66 views
  • 30 May, 2021
  • +127 other locations
Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients

The purpose of this study is to compare the efficacy and safety of 2 doses of crizanlizumab (5.0 mg/kg and 7.5 mg/kg) versus placebo in adolescent and adult sickle cell disease (SCD) patients with history of vaso-occlusive crisis (VOC) leading to healthcare visit.

glutamine
electrophoresis
opioid
conjugated bilirubin
chest syndrome
Novartis Investigative Site
 (2.8 away) Contact site
  • 100 views
  • 10 Jun, 2021
  • +86 other locations
A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (LEAP-010) (MK-7902-010)

This is a study of pembrolizumab (MK-3475) with or without lenvatinib (E7080/MK-7902) as a first line intervention in a PD-L1 selected population with participants with recurrent or metastatic head and neck squamous cell carcinoma. Hypotheses include: Pembrolizumab + lenvatinib is superior to pembrolizumab + placebo with respect to Objective Response …

measurable disease
oropharyngeal
squamous cell carcinoma
pembrolizumab
caries
Universitaetsklinikum Koeln ( Site 2111)
 (2.8 away) Contact site
  • 15 views
  • 18 Jun, 2021
  • +146 other locations
A Study to Assess the Efficacy and Safety of Budesonide/Albuterol Metered-dose Inhaler (BDA MDI/PT027) in Adults and Children 4 Years of Age or Older With Asthma

This is a randomized, double-blind, multicenter, parallel-group, variable-length study to compare 2 doses of BDA MDI (PT027) with AS MDI (PT007) on the time to first severe asthma exacerbation in adult, adolescent, and pediatric subjects with moderate to severe asthma.

muscarinic antagonists
budesonide
theophylline
leukotriene receptor antagonist
spirometry
Research Site
 (9.7 away) Contact site
  • 2319 views
  • 12 Mar, 2021
  • +280 other locations
International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma

Primary objectives: Randomization R1, all patients eligible: To examine, whether the cumulative incidence of relapses with involvement of the CNS (CNS relapse, pCICR) can be decreased by a modified induction therapy including dexamethasone (experimental arm) instead of prednisone (standard arm) Randomization R2, only patients with high risk LBL eligible: to …

Zentrum f r Kinderheilkunde der Universit t Bonn, Abt. P d. H matologie / Onkologie
 (15.0 away) Contact site
  • 0 views
  • 19 Jun, 2021
  • +223 other locations
A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer

The reason for this study is to see if the study drug selpercatinib compared to a standard treatment is effective and safe in participants with rearranged during transfection (RET) fusion-positive non-squamous non-small cell lung cancer (NSCLC) that has spread to other parts of the body. Participants who are assigned to …

progressive disease
non-squamous non-small cell lung cancer
pembrolizumab
lung carcinoma
carboplatin
Universit tsklinikum K ln
 (2.8 away) Contact site
  • 16 views
  • 20 Jun, 2021
  • +317 other locations