Cologne, Germany Clinical Trials

A listing of Cologne, Germany clinical trials actively recruiting patients volunteers.

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Found 90 clinical trials
Study of Ibrutinib Combined With Venetoclax in Subjects With Mantle Cell Lymphoma (SYMPATICO)

This Phase 3 multinational, randomized, double-blind study is designed to compare the efficacy and safety of the combination of ibrutinib and venetoclax vs. ibrutinib and placebo in subjects with MCL.

ibrutinib
mantle cell lymphoma
cyclin d1
renal function tests
TP53
Universitatsklinikum Koln
 (2.8 away) Contact site
  • 908 views
  • 01 Aug, 2021
  • +179 other locations
A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis Post Polycythemia Vera Myelofibrosis or Post-Essential Thrombocythemia Myelofibrosis

This study (study ID PAC203 North America; PAC303 ex-North America) is evaluating 200 mg BID of pacritinib compared to physician's choice (P/C) therapy in patients with MF and severe thrombocytopenia (platelet count <50,000/L). Approximately 348 patients in total will be enrolled, randomized 2:1 to either pacritinib (approximately 232 patients) or …

platelet count
myelofibrosis
thrombocytosis
blast cells
conjugated bilirubin
Johannes Wesling Hospital Minden, Department of Oncology and Hematology
 (124.8 away) Contact site
  • 506 views
  • 19 Jul, 2021
  • +177 other locations
The Efficacy and Safety of REX-001 to Treat Ischemic Ulcers in Subjects With CLI Rutherford Category 5 and DM

This trial is a pivotal, placebo-controlled, double-blind, parallel-group, adaptive trial conducted in subjects with DM and CLI Rutherford Category 5. Minimisation will be used to assign eligible subjects in a 2:1 ratio to receive a single intra-arterial administration of REX-001 or matching placebo into the index limb.

glycosylated hemoglobin
estrogen
revascularisation
hemoglobin a1c
ischemic ulcer
Universit tklinikum K ln (AoR)-Klinik und Poliklinik f r Gef sschirurgie, Herzzentrum
 (2.8 away) Contact site
  • 36 views
  • 12 May, 2021
  • +34 other locations
Atezolizumab With Bevacizumab and Chemotherapy vs Bevacizumab and Chemotherapy in Early Relapse Ovarian Cancer

This is a phase III, randomized, partially blinded, multicenter trial to evaluate the efficacy and safety of atezolizumab plus bevacizumab and chemotherapy compared to placebo plus bevacizumab and chemotherapy in patients with recurrent ovarian-, fallopian tube, or primary peritoneal cancer with 1st or 2nd relapse within 6 months after platinum …

Universit tsfrauenklinik Bonn
 (15.0 away) Contact site
  • 65 views
  • 02 Aug, 2021
  • +155 other locations
Study of Rezafungin Compared to Caspofungin in Subjects With Candidemia and/or Invasive Candidiasis

The purpose of this pivotal study is to determine if intravenous Rezafungin is efficacious and safe in the treatment of candidemia and/or invasive candidiasis when compared to caspofungin (followed by optional oral fluconazole).

microscopic examination
blood culture
candidiasis
antifungal therapy
antibiotics
University Hospital K ln
 (2.8 away) Contact site
  • 220 views
  • 13 Jun, 2021
  • +150 other locations
Study of Durvalumab + Tremelimumab Durvalumab and Placebo in Limited Stage Small-Cell Lung Cancer in Patients Who Have Not Progressed Following Concurrent Chemoradiation Therapy

This is a Phase III, Randomized, Double-blind, Placebo-controlled, Multi-center, International Study of Durvalumab or Durvalumab and Tremelimumab as Consolidation Treatment for Patients with LS-SCLC Who Have Not Progressed Following Concurrent Chemoradiation Therapy

etoposide
chemoradiotherapy
limited stage small cell lung cancer
prophylactic cranial irradiation
cancer chemotherapy
Research site
 (4.0 away) Contact site
  • 268 views
  • 01 Aug, 2021
  • +246 other locations
Brief Title: Study of Efficacy and Safety of Canakinumab as Adjuvant Therapy in Adult Subjects With Stages AJCC/UICC v. 8 II-IIIA and IIIB (T>5cm N2) Completely Resected Non-small Cell Lung Cancer Acronym: CANOPY-A

The primary purpose of the study is to compare the efficacy and safety of canakinumab versus placebo as adjuvant therapy in adult subjects with stages AJCC/UICC v. 8 II -IIIA and the subset of IIIB (T>5cm N2 disease) completely resected (R0) non-small cell lung cancer (NSCLC).

alopecia
systemic therapy
lung carcinoma
Novartis Investigative Site
 (5.3 away) Contact site
  • 645 views
  • 15 Jul, 2021
  • +414 other locations
Study Comparing Zanubrutinib + Rituximab Versus Bendamustine + Rituximab in Participants With Untreated Mantle Cell Lymphoma

This is a randomized study to compare the efficacy and safety of zanubrutinib plus rituximab versus bendamustine plus rituximab in previously untreated participants with mantle cell lymphoma (MCL) who are not eligible for stem cell transplantation.

Universit tsklinikum K ln
 (2.8 away) Contact site
  • 40 views
  • 28 Jun, 2021
  • +121 other locations
PREvention of STroke in Intracerebral haemorrhaGE Survivors With Atrial Fibrillation

Atrial fibrillation (AF) is the most common form of irregular heart rhythm. In people with AF, blood clots often form in the heart, which can travel to the brain. Blockage of brain arteries by these clots is a major cause of stroke. This type of stroke is called an ischaemic …

intracerebral hemorrhage
edoxaban
anticoagulants
brain imaging
apixaban
University Hospital Cologne
 (2.8 away) Contact site
  • 13 views
  • 25 Feb, 2021
  • +27 other locations
TAK-788 as First-line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations

The purpose of this study is to compare the efficacy of TAK-788 as first-line treatment with that of platinum-based chemotherapy in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose tumors harbor epidermal growth factor receptor (EGFR) exon 20 insertion mutations.

Uniklinik Koln
 (2.8 away) Contact site
  • 30 views
  • 04 Feb, 2021
  • +165 other locations