Toulose, France Clinical Trials

A listing of Toulose, France clinical trials actively recruiting patients volunteers.

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Found 128 clinical trials
Evaluation of the Safety and Efficacy of the Association of Ibrutinib and Daratumumab in Relapsed/Refractory Chronic Lymphocytic Leukemia With p53 Dysfunction

Ibrutinib, a first-in-class Bruton Tyrosine kinase (BTK) inhibitor, has become an established treatment in relapsed/refractory chronic lymphocytic leukemia (CLL). However, despite a considerable improvement of Progression Free Survival (PFS) and Overall Survival (OS) in comparison with historical controls, the prognosis of patients with 17p deletion (del17p) remains a concern, as …

IUCT ONCOPOLE - H matologie
 (2.3 away) Contact site
  • 2 views
  • 07 Jul, 2021
  • +41 other locations
Lorlatinib After Failure of First-line Second-generation ALK Kinase Inhibitor in Patients With Advanced ALK-positive Non-small Cell Lung Cancer

Crizotinib is a first-generation ALK tyrosine kinase inhibitor (ITK-ALK). It is the standard first-line treatment for patients with advanced NSCLC with ALK gene rearrangement. Alectinib, ceritinib and brigatinib are second-generation ITK-ALK. They have been shown to be effective in the first line of treatment in randomized trials. Alectinib has shown …

Montpellier - CHU
 (121.2 away) Contact site
  • 0 views
  • 26 Jan, 2021
  • +29 other locations
Consolidative Radiotherapy for Metastatic Urothelial Bladder Cancer Patients Without Progression and With no More Than Three Residual Metastatic Lesions Following First Line Systemic Therapy

This is a phase II, multicenter, randomized open-label and comparative study designed to evaluate whether local consolidative radiotherapy plus standard of care improves overall survival as compared to standard of care in patients with limited metastatic urothelial bladder cancer and without progression following the initial phase of first-line systemic therapy. …

Clinique Claude Bernard
 (41.4 away) Contact site
  • 0 views
  • 24 Jun, 2021
  • +12 other locations
Phase II Study to Evaluate MAintenance Therapy With Olaparib or Selumetinib Plus Durvalumab According to BRCAness and KRAS Somatic Status Personalized in Metastatic Pancreatic Adenocarcinoma Patients

MAZEPPA is open-label, phase II study to assess the efficacy of a genomic-driven maintenance therapy in terms of PFS in Pancreatic ductal adenocarcinoma (PDAC) patients with disease controlled after 4 months of mFOLFIRINOX chemotherapy as following: Patients with a BRCAness somatic profile: olaparib Arm A. Patients with no BRCAness profile …

Polyclinique Bordeaux Nord Aquitaine
 (131.0 away) Contact site
  • 0 views
  • 27 Jan, 2021
  • +28 other locations
Pilot and Phase 2 Study of the Efficacy of a Treatment Protocol With Dexamethasone Implant Loading Dose in Patients With Diabetic Macular Edema (LOADEX)

Nowadays, steroids and anti-VEGF are the first line treatment for diabetic macular edema. Ozurdex is the most frequently used steroid and has label for both first and second line treatment. Ozurdex treatment paradigm for patients with diabetic macular edema is to inject patient only in case of huge recurrence. The …

CHU Bordeaux - H pital Pellegrin
 (131.2 away) Contact site
  • 0 views
  • 18 Apr, 2021
  • +19 other locations
Lorlatinib After Failure of First-line TKI in Patients With Advanced ROS1-positive NSCLC (ALBATROS)

ROS1 rearrangements are present in 1-2% of NSCLC cases and define a distinct molecular subgroup. Like ALK (anaplastic lymphoma kinase) rearrangements in NSCLC, ROS1 fusions confer sensitivity to the inhibitor crizotinib. Crizotinib, which is a tyrosine kinase inhibitor (TKI), has been shown to be effective in tumors in several retrospective …

Bordeaux - CHU
 (131.0 away) Contact site
  • 0 views
  • 07 Jun, 2021
  • +38 other locations
Abemaciclib (LY2835219) in Men With Heavily Treated Metastatic Castration-Resistant Prostate Cancer

The study will evaluate how safe and effective abemaciclib is when given to participants whose metastatic prostate cancer progresses after they had received several previous treatments.

Institut Claudius Regaud
 (2.0 away) Contact site
  • 0 views
  • 16 Jul, 2021
  • +18 other locations
Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated (RB SFCE 2009)

Postoperative Treatment of Unilateral Retinoblastoma After Primary Enucleation according to histopathological risk factors of the International Retinoblastoma Staging Working Group.

carboplatin
vincristine
etoposide
cyclophosphamide
renal function
Hopital Arnaud de Villeneuve
 (116.2 away) Contact site
  • 36 views
  • 24 Jan, 2021
  • +27 other locations
EXCELLENT (EXpanded CELL ENdocardiac Transplantation)

A multicentric controlled phase I / IIb study evaluating the safety and the efficacy of in vitro expanded peripheral blood CD34+ stem cells output by the StemXpand Automated Process, and injected in patients with an acute myocardial infarction and a LVEF remaining below 50% after reperfusion versus standard of care.

coronary angioplasty
troponin
ejection fraction
CHU Montpellier Arnaud-De-Villeneuve
 (121.2 away) Contact site
  • 0 views
  • 11 Jul, 2021
  • +12 other locations
Active Surveillance With or Without Apalutamide Treatment in Low Risk Prostate Cancer

Many prostate cancer are slow or non progressive forms that would never impair quality or quantity of like of life if undetected. For this localized prostate cancer, the recommendation is an active surveillance, however often experienced by the patient as a lack of care. Thus the introduction of new potent …

Clinique La Croix Du Sud
 (5.2 away) Contact site
  • 26 views
  • 23 Jan, 2021
  • +10 other locations