St Priest-En-Jarez, France Clinical Trials

A listing of St Priest-En-Jarez, France clinical trials actively recruiting patients volunteers.

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Found 360 clinical trials
Consolidative Radiotherapy for Metastatic Urothelial Bladder Cancer Patients Without Progression and With no More Than Three Residual Metastatic Lesions Following First Line Systemic Therapy

This is a phase II, multicenter, randomized open-label and comparative study designed to evaluate whether local consolidative radiotherapy plus standard of care improves overall survival as compared to standard of care in patients with limited metastatic urothelial bladder cancer and without progression following the initial phase of first-line systemic therapy. …

Centre Jean Perrin
 (65.6 away) Contact site
  • 0 views
  • 20 Jun, 2021
  • +11 other locations
Efficacy and Safety of Brodalumab Compared With Guselkumab in the Treatment of Plaque Psoriasis After Inadequate Response to Ustekinumab

The trial investigates the efficacy and safety of brodalumab against guselkumab in treatment for patients with moderate-to-severe plaque psoriasis who still have some remaining symptoms after ustekinumab treatment.

plaque psoriasis
ustekinumab
guselkumab
LEO Pharma Investigational Site
 (2.4 away) Contact site
  • 0 views
  • 02 Jun, 2021
  • +70 other locations
A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)

Patients with HER2-positive primary breast cancer (BC) who do not achieve complete response after appropriate neoadjuvant therapy are at higher risk of disease recurrence. More effective treatment options are needed for this patient population. This study will examine the efficacy and safety of trastuzumab deruxtecan (T-DXd) compared with trastuzumab emtansine …

Centre Leon Berard
 (29.7 away) Contact site
  • 0 views
  • 13 Jun, 2021
  • +422 other locations
Impact of Early Low-Calorie Low-Protein Versus Standard Feeding on Outcomes of Ventilated Adults With Shock

Among critically ill patients requiring mechanical ventilation and catecholamines for shock, nearly 40% to 50% die, and functional recovery is often delayed in survivors. International guidelines include early nutritional support (48 h after admission), 20-25 kcal/kg/d at the acute phase, and 1.2-2 g/kg/d protein. These targets are rarely achieved in …

Hopital de la Croix-Rousse
 (29.7 away) Contact site
  • 0 views
  • 23 Jan, 2021
  • +50 other locations
A Study to Assess the Efficacy and Safety of a Subcutaneous Formulation of Efgartigimod PH20 SC in Adults With Pemphigus (Vulgaris or Foliaceus)

This is a prospective, multicenter, randomized, double-blinded, placebo-controlled trial to investigate the efficacy, safety, patient outcome measures, tolerability, immunogenicity, PK, and PD of efgartigimod PH20 SC in adult participants aged from 18 years with PV or PF. The trial comprises a screening period of up to 3 weeks, a treatment …

methotrexate
treatment regimen
prednisone
cyclophosphamide
azathioprine
Investigator site 32 - FR0330026
 (2.4 away) Contact site
  • 0 views
  • 14 Jun, 2021
  • +70 other locations
A Phase III Double-blind Study to Assess Safety and Efficacy of an RSV Maternal Unadjuvanted Vaccine in Pregnant Women and Infants Born to Vaccinated Mothers

The purpose of this study is to evaluate the ability of a single dose of the investigational RSV Maternal vaccine, administered intramuscularly to pregnant women aged 18-49 years, in good general maternal health, in preventing medically assessed RSV associated Lower Respiratory Tract Illnesses (LRTIs) in infants born to vaccinated mothers. …

GSK Investigational Site
 (2.4 away) Contact site
  • 0 views
  • 19 Jun, 2021
  • +102 other locations
Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Crohn's Disease

The primary objectives of this study are to evaluate the safety and efficacy of filgotinib during induction and maintenance treatment of moderately to severely active Crohn's disease (CD) in participants who are biologic-naive and biologic-experienced. Participants who complete the study, or do not meet protocol response or remission criteria at …

tumor necrosis factor alpha
remission
vedolizumab
ustekinumab
tumor necrosis factor
Centre Hospitalier Universitaire de Lyon Sud
 (26.5 away) Contact site
  • 0 views
  • 31 May, 2021
  • +550 other locations
Study of Ravulizumab in Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN)

The objectives of this study are to evaluate the safety and efficacy of ravulizumab administered by intravenous (IV) infusion compared to placebo and demonstrate proof-of-concept of the efficacy of terminal complement inhibition in participants with LN (LN Cohort) or IgAN (IgAN Cohort).

proteinuria
nephritis
immunosuppression
nephropathy
lupus
Clinical Study Site
 (2.4 away) Contact site
  • 0 views
  • 11 Jun, 2021
  • +21 other locations
Efficacy and Safety of Calcifediol vs Placebo in Subjects With Vitamin D Deficiency

This is a randomised, double-blind, double-dummy, multicentre, dose-ranging clinical trial in subjects with vitamin D deficiency or insufficiency. Its general objective is to determine the efficacy and safety of different doses of calcifediol soft gelatin capsules (SGCs) compared to placebo.

CHU Saint Etienne
 (2.4 away) Contact site
  • 0 views
  • 12 Mar, 2021
  • +47 other locations
Intraoperative Protective Mechanical Ventilation in Patients Requiring Emergency Abdominal Surgery

The aim of this study is to compare the effects of a strategy aimed at increasing alveolar recruitment (high PEEP levels adjusted according to driving pressure and recruitment maneuvers) with that of a strategy aimed at minimizing alveolar distension (low PEEP level without recruitment maneuver) on postoperative respiratory failure and …

University Hospital
 (2.4 away) Contact site
  • 0 views
  • 29 Apr, 2021
  • +25 other locations