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Limoges Cedex 1, France Clinical Trials

A listing of Limoges Cedex 1, France clinical trials actively recruiting patients volunteers.

Found (156) clinical trials

A Trial of Doxycycline vs. Standard Supportive Therapy in Newly-diagnosed Cardiac AL Amyloidosis Patients Undergoing Bortezomib-based Therapy

Systemic amyloidoses are rare diseases affecting approximately 1 in 100,000 persons each year. In systemic amyloidoses abnormal proteins deposit in bodily organs and severely impair their function, causing death if not treated effectively. Light chain (AL) amyloidosis is caused by a usually small population of plasma cells (the cells that …

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Adjuvant Palbociclib in Elderly Patients With Breast Cancer

The primary objective of this trial is to assess the efficacy of the combination of at least 5 year endocrine therapy and 2 year-palbociclib as adjuvant systemic treatment instead of adjuvant chemotherapy followed by endocrine therapy in older patients with stage II-III ER+/HER2- early breast cancer. This is a two-arm …

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Evaluation of Pain Sensitization in Rheumatoid Arthritis: Analysis on a Cohort of Tofacitinib Treated Patients

Persistent pain and chronic fatigue are very common complaints in rheumatoid arthritis (RA) patients, whatever the anti-inflammatory treatment response. Interestingly, pain remaining despite good clinical response was associated with high disability and low inflammation at baseline, suggesting a mechanism of pain independent of inflammation in these patients. Such patients, with …

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Study to Collect Information About Invasive Disease Caused by Extraintestinal Pathogenic Escherichia Coli-2 (EXPECT-2)

Janssen Research & Development is developing ExPEC10V, a 10-valent conjugate vaccine comprising the 10 most predominant O-polysaccharides of ExPEC. Invasive ExPEC Disease (IED) is defined as an acute illness consistent with bacterial infection that is microbiologically confirmed either by the isolation and identification of E. coli from blood or other …

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Safety and Efficacy of Ponatinib Followed by Imatinib in Patients With Chronic Myelogenous Leukemia in Chronic Phase

TREATMENT PLAN : All eligible patients will be treated: During the induction Phase (Month 1 to Month 6) with ponatinib (30mg/day) single agent; then During the consolidation Phase (Month 7 to Month 36) with imatinib (400mg/day) single agent; then From M36 : Patients with stable MR4.5 (i.e. since at least …

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Efficacy Safety and Tolerability of Nangibotide in Patients With Septic Shock

This is a randomized, double-blind, placebo-controlled dose-selection study in which two doses of nangibotide are tested versus placebo. All patients with a diagnosis of septic shock will be considered for study participation. All potential study patients will receive standard of care for the treatment of septic shock. After screening for …

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adaptatiVe Endovascular Strategy to the CloT MRI in Large Intracranial Vessel Occlusion

Sudden occlusion of an intracranial artery by a thrombus represents the initial and pivotal event of large vessel occlusion acute ischemic stroke (AIS). The primary goal of AIS treatment is to re-open this artery with intravenous tissue-type plasminogen activator infusion (IV t-PA) and/or endovascular therapy (EVT). Thrombus characterization could be …

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Chewing Gum Test for the Diagnosis of Giant Cell Arteritis (Horton's Disease) - ChewingHort

GCA is the most common vasculitis. The diagnosis easily could be made in patients over 50 years old with headache, inflammatory belt pain, claudication of the jaws, scalp hyperesthesia, ophthalmological manifestations and an inflammatory syndrome. However, the clinical pictures could be less suggestive, hence diagnostic difficulties. Some patients have only …

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Study of DS-8201a an Antibody Drug Conjugate for Advanced Breast Cancer Patients With Biomarkers Analysis

The main objective is to evaluate the anti-tumor activity of DS-8201a in three cohorts of advanced breast cancer patients: Cohort 1: HER2 over-expressing (HER2 IHC3+ or HER2 IHC2+/ISH+) Cohort 2: HER2 low-expressing (IHC1+ or IHC2+/ISH-) Cohort 3: HER2 non-expressing (IHC0+)

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Evaluation of the Efficacy of the Individually Adjusted Therapy Scale (ATI) on the Addiction Severity

Addiction is one of the most prevalent psychiatric disorders in general population. In the DSM-5, substance abuse and substance dependence have been combined into a single substance use disorder and gambling disorder is now reclassified in the new substance-related and addictive disorders category. Moreover, a criterion assessing the craving has …

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