La-Roche-Sur-Yon, France Clinical Trials

A listing of La-Roche-Sur-Yon, France clinical trials actively recruiting patients volunteers.

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Found 34 clinical trials
Study Comparing Inhaled Amikacin Versus Placebo to Prevent Ventilator Associated Pneumonia

The objective of the study is to prove that after the third day of invasive mechanical ventilation a three-day course of inhaled amikacin reduces the incidence of subsequent VAP. Parallel two group double blind randomized controlled clinical trial. Individual randomization, performed on day 4 of invasive mechanical ventilation, will be …

antibiotic therapy
mechanical ventilation
antibiotics
Service de R animation M dicale - CHD Les Oudairies
 (0.2 away) Contact site
  • 3 views
  • 01 Mar, 2021
  • +41 other locations
Double Immune Checkpoint Inhibitors in PD-L1-positive Stage IV Non-small Lung CancEr

Non Small Cell lung cancer (NSCLC) remains the first cause of death by cancer in the World. For the patients presenting a NSCLC stage IV, the median of survival is about 15 months today. The chemotherapy with platinum is the standard treatment for these patients but immunotherapy showed these efficacy …

metastasis
gilbert's syndrome
nivolumab
pd-l1
tumor cells
CH
 (37.1 away) Contact site
  • 22 views
  • 25 Jan, 2021
  • +45 other locations
Evaluation in the Treatment of Neuropathic Pain Post Breast Surgery

Breast cancer is the most common cancer in women in Europe. Therefore, breast cancer has become a chronic disease and patients need to learn to live with it as well as with the adverse effects related to the disease itself or to the therapies used. As noted in the third …

Institut de Cancerologie de L'Ouest
 (71.3 away) Contact site
  • 12 views
  • 22 Jan, 2021
  • +9 other locations
A Phase III Randomized Blind Double Dummy Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion

The aim of the THEIA study is to determine if Alteplase administrated within 4.5 hours improve visual deficit due to acute CRAO with a good safety profile.

CHD Vend e
 (0.7 away) Contact site
  • 21 views
  • 27 Jan, 2021
  • +26 other locations
AScalate: Treat-to-target in Axial Spondyloarthritis

This is a randomized, parallel-group, open-label, multicenter study of patients with active axSpA. The aim is to demonstrate that the efficacy of a Treat-to-Target (T2T) approach (with secukinumab as first-line biologic) is superior to a Standard-Of-Care (SOC) approach in terms of achieving strong clinical efficacy in patients with active axial …

spondylitis
MRI
adalimumab
secukinumab
NSAID
Novartis Investigative Site
 (0.7 away) Contact site
  • 1 views
  • 28 Jul, 2021
  • +43 other locations
A Study to Assess the Effects of Brolucizumab in Adult Patients With Neovascular Age Related Macular Degeneration

Neovascular age-related macular degeneration (nAMD) is characterized by the presence of choroidal neovascularization (CNV). Choroidal neovascularization consists of abnormal blood vessels originating from the choroid and can lead to hemorrhage, fluid exudation, and fibrosis, resulting in photoreceptor damage and vision loss. The safety and efficacy of brolucizumab has been demonstrated …

Novartis Investigative Site
 (0.7 away) Contact site
  • 0 views
  • 19 Jul, 2021
  • +48 other locations
Combination of Baricitinib and Adalimumab in Rheumatoid Arthritis

As stated by the European League Against Rheumatism (EULAR) and the Societe Francaise de Rhumatologie (SFR), treatment of patients with rheumatoid arthritis (RA) should target sustained remission or at least low disease activity. However, despite significant advances based on various combinations of conventional synthetic disease-modifying antirheumatic drugs (DMARDs) and biologic …

rituximab
adalimumab
prednisone
baricitinib
corticosteroids
CHRU du Tours - service de rhumtologie
 (110.9 away) Contact site
  • 0 views
  • 21 Jul, 2021
  • +19 other locations
Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC

This study compares rPFS in men with mCRPC treated with talazoparib plus enzalutamide vs. enzalutamide after confirmation of the starting dose of talazoparib in combination with enzalutamide.

CHD Vend e
 (0.7 away) Contact site
  • 4293 views
  • 01 Aug, 2021
  • +502 other locations
A Study Comparing Zanubrutinib With Bendamustine Plus Rituximab in Participants With Previously Untreated CLL or SLL

To compare efficacy between zanubrutinib versus bendamustine and rituximab in patients with previously untreated CLL/SLL, as measured by progression free survival.

bendamustine
rituximab
chemoimmunotherapy
fludarabine
venetoclax
Centre Hospitalier Universitaire Nantes - Hotel Dieu
 (38.2 away) Contact site
  • 1222 views
  • 08 May, 2021
  • +242 other locations
Randomised Study Evaluating Adjuvant Chemotherapy After Resection of Stage III Colonic Adenocarcinoma in Patients of 70 and Over

Colorectal cancer occurs mainly in elderly patients. Recent estimation showed that in France more than 50% of the patients diagnosed with a colorectal cancer are 70 years old or more. Adjuvant chemotherapy has demonstrated a benefit on disease-free survival and overall survival after a stage III colon cancer resection. Nevertheless …

cancer
primary tumor
capecitabine
colon cancer
oxaliplatin
CHD Vend e
 (0.7 away) Contact site
  • 31 views
  • 24 Jan, 2021
  • +202 other locations