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  • Efficacy, Safety, Pharmacokinetics of ICP-488 in Patients With Moderate to Severe Plaque Psoriasis

    Phase

    3

    Span

    102 weeks

    Sponsor

    Beijing InnoCare Pharma Tech Co., Ltd.

    Nanjing, Jiangsu

    Recruiting

  • A Phase II/III Trial Comparing Transarterial Tirapazamine Embolization (TATE) With cTACE for Intermediate-stage Liver Cancer.

    Phase

    2/3

    Span

    210 weeks

    Sponsor

    Zhejiang Raygene Pharmaceuticals Co., Ltd

    Nanjing, Jiangsu

    Recruiting

  • Serial Coronary CTA-based Plaque Progression Detection for Management of Coronary Heart Disease

    Patients with non-obstructive coronary artery disease have a high rate of adverse cardiovascular events, and currently, there is still a lack of effective management strategies for these patients in clinical practice. In the SUCCESS study, investigator will compare follow-up CCTA management with routine clinical management to assess the effectiveness of follow-up CCTA in improving lipid control and reducing cardiovascular events in these patients. The SUCCESS study is a single-center, randomized, parallel-controlled, interventional clinical trial that recruits patients with non-obstructive coronary artery disease identified on previous CCTA (coronary artery stenosis of 20% to 70% or left main coronary artery stenosis of 20% to 50%). The experimental group is the CCTA follow-up management group, and the control group is the routine clinical follow-up management group. All participants will be randomly assigned to the experimental and control groups in a 1:1 ratio. The experimental group will undergo management using follow-up CCTA, while the control group will be managed using routine clinical and laboratory examinations. At the 1-year follow-up, all participants will undergo laboratory re-examination to observe the impact of follow-up CCTA on lipid target achievement. After 3 years of follow-up, the differences in the occurrence of major adverse cardiovascular and cerebrovascular events (MACCE) between the two groups will be compared.

    Phase

    N/A

    Span

    201 weeks

    Sponsor

    Zhang longjiang,MD

    Nanjing, Jiangsu

    Recruiting

  • Phase II Clinical Study of HDM1005 Injection in Obese Adults Without Diabetes Mellitus

    Phase

    2

    Span

    34 weeks

    Sponsor

    Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.

    Nanjing

    Recruiting

    Healthy Volunteers

  • Regional Lymph Node Metastasis and Survival Outcomes in Advanced HCC

    In patients with advanced-stage hepatocellular carcinoma (HCC), previous studies showed that transarterial chemoembolization (TACE) in combination with immune checkpoint inhibitors (ICIs) and molecular target therapies exhibited better efficacy (PFS and OS) as compared to the ICIs and molecular target therapies. Besides, previous studies showed that tumor-draining lymph nodes play an important role in anti-tumor immune responses in vivo and in vitro studies. However, the relationship between regional lymph node metastasis (LNM) and immunotherapy-based efficacy is unclear. Therefore, this study aimed to evaluate whether extrahepatic LNM is associated with worse survival outcomes as compared to other metastatic sites in patients with advanced HCC who received transarterial chemoembolization (TACE) in combination with ICIs and molecular target therapies. This real-world study may provide further information on treatment selection for clinical practice and trials.

    Phase

    N/A

    Span

    370 weeks

    Sponsor

    Zhongda Hospital

    Nanjing, Jiangsu

    Recruiting

  • To Evaluate the Clinical Study of GS1191-0445 Injection in the Treatment of Hemophilia A

    Phase

    3

    Span

    296 weeks

    Sponsor

    Gritgen Therapeutics Co., Ltd.

    Nanjing, Jiangsu

    Recruiting

  • TQC2731 Clinical Trial for the Treatment of Severe Asthma With Injection

    Phase

    3

    Span

    119 weeks

    Sponsor

    Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.

    Nanjing, Jiangsu

    Recruiting

  • Clinical Trial of TQB2825 Injection Combined Immunochemotherapy in Subjects With Diffuse Large B Cell Lymphoma

    Phase

    1/2

    Span

    89 weeks

    Sponsor

    Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

    Nanjing, Jiangsu

    Recruiting

  • Hypofractionated Radiation Fractionation in Breast Cancer Patients with Implant-Based Reconstruction

    Patients with breast cancer frequently have requirement for breast reconstruction after mastectomy. For patients with limited autologous tissue availability, implant-based reconstruction remains an effective alternative. Due to the absence of high-level evidence, collaborative efforts between surgical and radiation oncology teams are advised to determine the optimal sequencing and techniques for integrating reconstruction surgery with radiotherapy. The ongoing Alliance A221505 and FABREC phase III randomized controlled trials are comparing the incidence of reconstructive complications following hypofractionated and conventional fractionation radiotherapy. FABREC trial recently showed the hypofractionated regimen did not significantly improve change in physical well-being(PWB), domain of the Functional Assessment of Cancer Therapy-Breast (FACT-B) quality-of-life assessment tool, compared with the conventional fractionation radiotherapy. This trial added to the increasing experience with HF PMRT in patients with implant-based reconstruction. In 2019, the European Society for Radiotherapy and Oncology (ESTRO) provided guidelines for target delineation based on the position of the implant in breast reconstruction to minimize the irradiation of normal tissues. Existing studies on the risk of complications from irradiating expanders and implants have yielded inconsistent conclusions, with each approach having its own advantages and disadvantages. Our study aims to compare the incidence of reconstructive complications between hypofractionated and conventional fractionation radiotherapy after implant-based reconstruction surgery to provide high-level evidence for medium-dose hypofractionated radiotherapy after immediate implant-based reconstructive surgery.

    Phase

    N/A

    Span

    466 weeks

    Sponsor

    The First Affiliated Hospital with Nanjing Medical University

    Nanjing, Jiangsu

    Recruiting

  • Clinical Trial of TQB2825 Injection Combined With Chemotherapy in Subjects With Diffuse Large B-cell Lymphoma

    Phase

    2

    Span

    155 weeks

    Sponsor

    Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.

    Nanjing, Jiangsu

    Recruiting

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