Clermont Ferrand cedex 01, France Clinical Trials

A listing of Clermont Ferrand cedex 01, France clinical trials actively recruiting patients volunteers.

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Found 102 clinical trials
Safety and Efficacy of Nonacog Beta Pegol (N9-GP) in Previously Untreated Patients With Haemophilia B

This trial is conducted globally. The aim of the trial is to investigate the safety and efficacy of nonacog beta pegol (N9-GP) in previously untreated patients with Haemophilia B.

blood components
nonacog beta pegol
factor ix
coagulation factors
coagulation factor
Novo Nordisk Investigational Site
 (211.4 away) Contact site
  • 379 views
  • 15 Mar, 2021
  • +74 other locations
Study of Ibrutinib Combined With Venetoclax in Subjects With Mantle Cell Lymphoma (SYMPATICO)

This Phase 3 multinational, randomized, double-blind study is designed to compare the efficacy and safety of the combination of ibrutinib and venetoclax vs. ibrutinib and placebo in subjects with MCL.

TP53
ibrutinib
mantle cell lymphoma
venetoclax
cyclin d1
CHU Clermont Ferrand - H pital d'Estaing
 (0.7 away) Contact site
  • 908 views
  • 01 Aug, 2021
  • +179 other locations
Randomised Study Evaluating Adjuvant Chemotherapy After Resection of Stage III Colonic Adenocarcinoma in Patients of 70 and Over

Colorectal cancer occurs mainly in elderly patients. Recent estimation showed that in France more than 50% of the patients diagnosed with a colorectal cancer are 70 years old or more. Adjuvant chemotherapy has demonstrated a benefit on disease-free survival and overall survival after a stage III colon cancer resection. Nevertheless …

oxaliplatin
primary tumor
capecitabine
stage iii colon cancer
fluoropyrimidine
Institut de Canc rologie Lucien Neuwirth
 (65.2 away) Contact site
  • 31 views
  • 24 Jan, 2021
  • +202 other locations
Community-Acquired Pneumonia : Evaluation of Corticosteroids

Mortality of severe Community-Acquired Pneumonia (CAP) has not declined over time and is between 25 and 30% in sub-groups of patients. Corticosteroids (CTx) could down-regulate pulmonary and systemic inflammation, accelerate clinical resolution and decrease the rate of inflammation-associated systemic complications. Two recent meta-analyses suggest a positive effect on severe CAP …

purulent sputum
antibiotic therapy
dyspnea
chest pain
antibiotics
Service de R animation M dicale Polyvalente, H pital G Montpied
 (2.1 away) Contact site
  • 4 views
  • 25 May, 2021
  • +64 other locations
The SYMPTOMS - SYstematic Elderly Medical Patients Thromboprophylaxis: Efficacy on Symptomatic OutcoMeS - Study

Venous thromboembolism (VTE) is a frequent condition, affecting 1.8 per 1,000 people every year. Admission to hospital is one of the main risk factors for VTE, and could account for up to 20% of all VTE, making VTE prevention in admitted patients an appealing option to reduce VTE global burden. …

thrombosis
enoxaparin
venous thromboembolism
anticoagulants
clot
CHU de Saint Etienne
 (66.5 away) Contact site
  • 7 views
  • 26 Jan, 2021
  • +77 other locations
Study to Assess Efficacy and Safety of Cx601 Adult Allogeneic Expanded Adipose-derived Stem Cells (eASC) for the Treatment of Complex Perianal Fistula(s) in Participants With Crohn's Disease (CD)

The purpose of this study is to evaluate the combined remission of complex perianal fistulas, defined as the clinical assessment at Week 24 of closure of all treated external openings that were draining at baseline despite gentle finger compression, and absence of collections greater than (>) 2 centimeter (cm) (in …

mercaptopurine
methotrexate
tumor necrosis factor
luminal
certolizumab pegol
CHU de Clermont-Ferrand - Estaing
 (1.2 away) Contact site
  • 202 views
  • 28 May, 2021
  • +177 other locations
REduced Dose Versus Full-dose of Direct Oral Anticoagulant After uNprOvoked Venous thromboEmbolism.

Patients with unprovoked venous thromboembolism (VTE) or VTE associated with persistent risk factors have a high risk of recurrence after stopping anticoagulation. In these patients, international guidelines recommend indefinite anticoagulation. However, prolonged use of warfarin or DOAC at therapeutic dose is associated with a significant risk of bleeding. Consequently, it …

aspirin
apixaban 2.5 mg
anticoagulants
anticoagulation therapy
warfarin
CHU de Clermont Ferrand - H pital Gabriel Montpied
 (1.3 away) Contact site
  • 7 views
  • 27 Jan, 2021
  • +58 other locations
A French Protocol for the Treatment of Acute Lymphoblastic Leukemia (ALL) in Children and Adolescents

A still major question in the field of acute lymphoblastic leukemia (ALL) in children - an extremely heterogeneous disease though curable in 80-90% of children and 70-80% of the adolescents - is the optimal use of L-asparaginase (ASNase). It is known that administering ASNase results in the depletion of asparagine …

lymphoid leukemia
asparaginase
induction therapy
pegaspargase
CHU
 (65.2 away) Contact site
  • 0 views
  • 22 Jan, 2021
  • +27 other locations
International Randomised Phase III Clinical Trial in Children With Acute Myeloid Leukaemia

The main purpose of this study is : To establish which number of doses of gemtuzumab ozogamicin (up to a maximum of 3 doses) is tolerated and can be safety delivered in combination with cytarabine plus mitoxantrone or liposomal daunorubicin in induction To compare mitoxantrone (anthracenedione) & cytarabine with liposomal …

ejection fraction
fludarabine
blast cells
myeloablative conditioning
gemtuzumab
Centre Hospitalier Universitaire de Clermont-Ferrand
 (1.6 away) Contact site
  • 0 views
  • 26 Jan, 2021
  • +58 other locations
A Comparative Study of 2 Doses of BM Autologous H-MSC+Biomaterial vs Iliac Crest AutoGraft for Bone Healing in Non-Union

ORTHOUNION is a multi-centre, open, comparative, randomized, clinical trial with three parallel arms that aims to compare the efficacy of three treatments to enhance bone healing in patients with long bone non-union.

Department of Orthopaedic Surgery, CHU Tours
 (159.0 away) Contact site
  • 20 views
  • 23 Jan, 2021
  • +18 other locations