Castelnau Le Lez, France Clinical Trials

A listing of Castelnau Le Lez, France clinical trials actively recruiting patients volunteers.

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Found 16 clinical trials
Investigation of Radium-223 Dichloride (Xofigo) a Treatment That Gives Off Radiation That Helps Kill Cancer Cells Compared to a Treatment That Inactivates Hormones (New Antihormonal Therapy NAH) in Patients With Prostate Cancer That Has Spread to the Bone Getting Worse on or After Earlier NAH

Researchers in this study want to compare how well drug radium-223 dichloride (Xofigo) and new (novel) anti-hormonal (NAH) therapy work in participants with prostate gland cancer which has spread to the bone and progressed on or after one line of NAH therapy. Meanwhile researchers want to compare the safety of …

Institut du Cancer de Montpellier - Val d'Aurelle
 (1.9 away) Contact site
  • 13 Jun, 2021
  • +144 other locations
Study of the Impact of a Targeted Decolonization of S. Aureus Persistent Carriers

S. aureus nasal carriage is a well-known risk factor for S. aureus infections in hemodialysis (HD) patients. Strains of carriage and infections are the same in >80% of cases We recently shown that persistent carriers of S. aureus, not intermittent ones are at increased risk of staphylococcal infections in HD. …

 (1.9 away) Contact site
  • 11 Feb, 2021
  • +18 other locations
Study Evaluating Denosumab on Bone and Vascular Metabolism in Osteoporotic Chronic Kidney Disease

Aim of this study is to evaluate in a population of old osteoporotic chronic kidney disease females the effect of denosumab: on bone mineral density (femoral T-score) at 24 months on bone mineral density evolution (femoral T-score) after 24 months of follow-up on bone mineral density evolution (lumbar T-score) after …

 (1.9 away) Contact site
  • 25 Jan, 2021
  • +9 other locations
Rotation or Change of Biotherapy After TNF Blocker Treatment Failure for Axial Spondyloarthritis

Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by inflammatory arthritis and enthesitis involving the spine. AxSpA prevalence is around 0.17% of the French population. Tumor necrosis factor (TNF) was the first target defined in axSpA. Since one third of axSpA patients failed to the first TNF blocker, many …

psoriatic arthritis
anti-rheumatic drugs
CHRU Montpellier
 (1.9 away) Contact site
  • 25 Jan, 2021
  • +25 other locations
Efficacy and Safety of Brodalumab Compared With Guselkumab in the Treatment of Plaque Psoriasis After Inadequate Response to Ustekinumab

The trial investigates the efficacy and safety of brodalumab against guselkumab in treatment for patients with moderate-to-severe plaque psoriasis who still have some remaining symptoms after ustekinumab treatment.

plaque psoriasis
LEO Pharma Investigational Site
 (1.9 away) Contact site
  • 02 Jun, 2021
  • +70 other locations
Weight-Adjusted vs Fixed Low Doses of Low Molecular Weight Heparin For Venous Thromboembolism Prevention in COVID-19

Worldwide observational studies indicate a significant prothrombogenic effect associated with SARS-CoV-2 infection with a high incidence of venous thromboembolism (VTE), notably life-threatening pulmonary embolism. According to recommendations for acute medical illnesses, all COVID-19 hospitalized patients should be given VTE prophylaxis such as a low molecular weight heparin (LMWH). A standard …

PCR test
Montpellier Academic Hospital
 (1.9 away) Contact site
  • 27 Jan, 2021
  • +17 other locations
The Effect of Dupilumab on Lung Function and Related Changes in Airway Volumes Detectable by Functional Respiratory Imaging in Patients With Moderate-severe Asthma

Primary Objective: To assess the effect of dupilumab on lung function and related changes in airway volumes detectable by functional respiratory imaging Secondary Objective: To evaluate the effect of dupilumab at Week 24 on bronchodynamics, hyperinflation, airway resistance, airway wall thickness, ventilation defects and mucus plugging derived from high-resolution computed …

fractional exhaled nitric oxide
pulmonary function test
leukotriene receptor antagonist
Investigational Site Number 2500001
 (1.9 away) Contact site
  • 13 Jun, 2021
  • +53 other locations
Extension to the MAGNIFY MS Trial on Mavenclad (Magnify MS Extension)

The primary purpose of this study is to evaluate the long-term effectiveness of Mavenclad tablets, in terms of disease activity and safety, in participants with highly-active relapsing multiple sclerosis (RMS) previously participating in the MAGNIFY MS trial MS700568_0022 (NCT03364036).

CHU de Montpellier H pital Gui de Chauliac- D partement de Neurologie
 (1.9 away) Contact site
  • 13 Jun, 2021
  • +47 other locations
Comparison of Two Strategies of Glucocorticoid Withdrawal in Rheumatoid Arthritis Patients

The purpose of this study is to compare the proportion of patients who could withdraw from prednisone and hydrocortisone one year after a progressive decrease of GC (GC tapering) or a hydrocortisone replacement therapy in rheumatoid arthritis in remission or low disease activity.

rheumatic diseases
Montpellier Hospital
 (1.9 away) Contact site
  • 11 Mar, 2021
  • +16 other locations
Comparison of Gastric By-Pass and Optimized Medical Treatment in Obese Diabetic Patients

The objectives are to compare the results of the Gastric By-Pass (GBP) to that of optimized medical therapy in patients with obesity and poorly controlled type 2 diabetes in terms of mortality, weight loss, glycemic control, quality of life, cost, cost-effectiveness and cost utility of these two strategies.

glycosylated hemoglobin
bariatric surgery
diabetes mellitus
hemoglobin a1c
Hopital Lapeyronie Chu Montpellier
 (1.9 away) Contact site
  • 25 Jan, 2021
  • +12 other locations