Castanet Tolosan, France

EXAMINATION OF SOME MOLECULES IN PLACENTAS OF PATIENTS WITH PLACENTA PREVIA, PLACENTA PERCREATA

In the hospital, blood tests are routinely taken preoperatively from patients hospitalized for placenta percreata and preavia. Blood samples of patients who do not have exclusion criteria and who agree to participate in the study will also be studied from routinely collected blood samples. During the hospitalization of these patients for delivery, following the clamping of the umbilical cord after the birth of the baby (after the bond between the mother and the baby is terminated), 2 ml (one teaspoon) of blood sample will be taken from the cord blood, centrifuged and the serum sample will be separated and stored at -80 degrees. A 3x3 cm piece will be taken from the umbilical cord and placenta (the baby's mate), which will be disposed of as medical waste in the postnatal process, covering all layers. The tissue samples will be placed in a container with 10% formol and preserved. At the time of umbilical cord blood and placenta sampling, these tissues are in a waste state and have no connection with the baby and mother, so there is no harm to the mother or baby during sampling. Tissues (placenta, umbilical cord) and 2 ml (one teaspoon) of blood sample from umbilical cord blood will be taken, centrifuged and serum sample will be separated and stored at -80 degrees Celsius to be used in other similar studies and projects planned to be carried out in the future. Patients to be selected for the control group will be determined according to the exclusion criteria and will be selected with a similar gestational week and gravida number as the case group (In other studies in the literature, control group patients were collected using this similarity). If the patients selected for the control group give birth at term, tissue samples will be taken. Umbilical cord blood will be collected and stored at -80 and included in the study. If the patient selected for the control group gives birth prematurely, gives birth in an external center or requests to withdraw from the study, the patient will be excluded from the study.

Is Preoperative Prediction of Intra-Abdominal Adhesions Possible?

Acute Coronary Syndrome and Acupressure

Acute Coronary Syndrome (ACS) affects millions of people every year; It refers to three types of coronary artery disease: unstable angina pectoris, non-ST-elevation myocardial infarction (NSTE MI) and ST-elevation myocardial infarction (STEMI). It is known that 19 million people in the world and 161 thousand people in our country lost their lives due to Cardiovascular Disease (CVD). Approximately 3 million people worldwide die due to STEMI.Individuals experiencing ACS generally; It is observed that he/she experiences burning, stinging and compressive chest pain, tachycardia, sweating, fatigue, dizziness, dyspnea, nausea, anxiety and depression.Management of the disease is combined with pharmacological applications; It is tried to be provided with non-pharmacological applications such as education, acupuncture and acupressure. When the literature is examined, acupressure application; in the physiological parameters of individuals with myocardial infarction; It brings blood pressure, heart rate and respiratory rate to normal limits, and increases oxygen saturation and sleep quality; It appears to reduce anxiety and pain.For all these reasons, this study aims to examine the effect of acupressure on physiological parameters (blood pressure, heart rate, respiratory rate, pain and cortisol) and anxiety levels in individuals diagnosed with ACS.

The Effect of the Vein Imaging Device Used in Peripheral Intravenous Catheter Application on the Success of the Procedure in Patients Coming to the Pediatric Emergency Department

Assistive devices may be needed to perform this procedure, which is quite painful and anxiety-inducing for children, all at once and in a short time. In this regard, there is no device support for PIC application for pediatric patients at Manisa Celal Bayar University Hafsa Sultan Hospital. The investigators predict that by introducing the vein imaging device to the Pediatric Emergency Department of our hospital, the success rate of PIC application will increase and the number of interventions will decrease by enabling the vein to be visualized and selected in pediatric patients. Due to these processes experienced by pediatric patients, the aim of our research is to examine the effect of the vein imaging device used during peripheral intravenous catheter application on the success of the procedure in pediatric patients. Method: The population of the research will consist of pediatric patients between the ages of 6-12 who applied to the Pediatric Emergency Department of Manisa Celal Bayar University, Hafsa Sultan Hospital. The adequacy of the sample size in the study "G. Calculated using the "Power-3.1.9.2" program. In the power analysis performed for the sample and power calculation of the experimental study, 30 pediatric patients were determined for each group at the p = 0.05 level, 80% representative power of the population and 95% confidence interval. However, considering the missing data, it was planned to conduct a study with 35 children for the experimental and control groups. Randomization was performed using the random numbers table obtained from the computer program (https://www.randomizer.org/). Research data will be collected at Manisa Celal Bayar University Hafsa Sultan Hospital Pediatric Emergency Service. The research was planned as an experimental (n: 35) and control (n: 35) group. In collecting data; - Informed Volunteer Consent Form (Appendix I). - Interview and Observation Form (Annex II). - Challenging Intravenous Intervention Score for Children (Appendix III). - ACCUVEIN AV 500 vein imaging device (Annex IV) - Peripheral cannula (Yellow color No. 24 G or Blue color No. 22 G) (Annex V): will be used. Data collection phase; Pediatric patients and their families who come to the pediatric emergency department will be informed about the vein imaging device to be used in the research and how the research will be conducted. Their consent will be taken. PIK placement attempt will be performed with the help of a vein imaging device in the experimental group, and with the traditional application method without device support in the control group. PIC placement in both groups will be performed by a specialist nurse working in the pediatric emergency department, who has 5 years of experience in caring for pediatric patients and performing IV interventions. In order to avoid differences in practice, the procedure for establishing peripheral vascular access for all children will be provided by the same nurse. In both groups, all PIK procedures will be performed with the same catheter number (24-G yellow or 22-G blue) and the same brand catheter (Braun) to avoid differences. Another pediatric emergency nurse who has been working in the pediatric emergency department for at least 2 years, independent of the research, will also act as an observer. When evaluating the duration of the PIK placement attempt; Before the child's vein is searched, the stopwatch will be turned on as soon as the tourniquet is tied and the time will be stopped when the patency of the vascular access is ensured (from the time the tourniquet is tied until the physiological saline is given). If the vascular access fails in the first attempt, a new vein will be searched and time will be kept until the procedure is successful. Once vascular access is established, the time will be stopped and the procedure time will be recorded. The observing nurse will evaluate the "Interview and Observation Form" and the "Difficult Intravenous Intervention Score for Children".

Does Endorphin Massage Reduce the Anxiety of Pregnant Women?

The sample size of the research was calculated using G*Power 3.1.9.4 software as a minimum of 34 with 95% power, 0.01 alpha, and 0.9 effect size. The sample size was planned as experimental (n=34) and control (n=34) groups. To ensure the equality of the samples in both groups, a simple randomization method was used, where pregnant women with odd hospital protocol numbers will be included in the experimental group and those with even numbers will be included in the control group. Pregnant women who are admitted for pre-cesarean section care will be informed about the study, and their voluntary consent will be obtained both in written and verbal form. Pre-tests will be administered to both the experimental and control groups at 08:00, and blood samples will be taken to measure cortisol levels. Subsequently, an intervention will be applied to those in the experimental group, while those in the control group will receive routine nursing care. At 09:00, post-tests will be administered to both the experimental and control groups, and blood samples will be taken again to measure cortisol levels. The pre-test and post-test results, as well as the mean cortisol levels, will be compared between the experimental and control groups.

A 52-Week Study to Learn About the Safety and Effects of Ritlecitinib in Participants With Nonsegmental Vitiligo

A Study of Roxadustat to Treat Anemia in Children and Teenagers With Chronic Kidney Disease

Effects of Myofascial Release Technique on Mobility, Sensorimotor Function and Performance in Volleyball Players

Sports that require overhead activities (volleyball, tennis, basketball) include components such as rapid displacement, strength and movement control.Volleyball is also called as an overhead sport in terms of the way it is played. In the realization of these sports; Sub-parameters such as proprioceptive sense, strength, throwing rate, flexibility play a role. During these activities, the shoulder and elbow joints are overloaded. To meet this load, the joint must provide the necessary mobility and stability. Proprioceptive sense in increasing the quality and width of movement as well as providing dynamic joint stability in overhead sports; Increasing the range of motion of the joint, reducing muscle stiffness and thus increasing flexibility are effective in providing mobility. That's why it's important to develop them. Likewise, muscle strength should be increased in order to maintain movement performance and prevent injuries. Performance is the evaluation of how much the psychological, physiological and biomechanical requirements required for a sportive activity are provided. Individual and team sports, by their very nature, result in winning and losing. In this respect, it is important that the performance is at the highest level. In addition to strength, speed is also an important parameter in performance. With the programs made by combining these parameters, sportive performance and athletic success can be increased. The ability to effectively perform parameters such as throwing, throwing and hitting the ball in overhead sports affects performance results. Athletes competing in branches where overhead movements requiring high muscle activity are used intensively; In addition to strength and flexibility, which are key components of performance, sensorimotor accuracy is also of great importance. Fascia; It is a body network that is the continuation of the connective tissue and is shaped by stretching, and it surrounds all organs and body structures. If the fascial tissue can be trained at the appropriate level (appropriate level of flexibility and elasticity), it can be beneficial in terms of protection from injuries as well as increasing sports performance. When we look at the literature, we see that the importance of this issue has increased in recent years. Myofascial release is an up-to-date method that appears to be effective in improving joint and fascia mobility, increasing body awareness, and aiding muscle reduction. Myofascial release application has become popular around the world in recent years, and it shows itself as one of the exercise trends of athletes.The use of myofascial release techniques as an exercise method has increased in recent years. Application; The effects on parameters such as strength, performance and flexibility were investigated. Studies have focused more on the lower extremities and acute effects. There is no study on the subject examining proprioceptive sensation in volleyball players in the upper extremity. Therefore, our aim is to examine the chronic effects of the application on shoulder and elbow joint mobility, sensorimotor function and performance. With the myofascial release application that we plan to do, we aim to improve these parameters and thus provide the athletes with an alternative application method in terms of preventing injuries and improving performance. When we review the literature, we are the first study to examine the effectiveness of myofascial release in the upper extremity and the long-term effects on athletes doing overhead activities. For all these reasons, the aim of this study is; To examine the effect of 8-week myofascial release application to the shoulder and elbow region on mobility, muscle strength, joint position sense, force matching, performance and well-being, and to examine the effect of the application at the 4th week, 8th week (end of the application), and 6th month after the first evaluation. is to detect whether there is a change in these parameters. In this study, the effect of myofascial release on shoulder and elbow joints in overhead volleyball players will be investigated for the first time. We think that our study will shed light on the studies to be done in healthy and symptomatic individuals who are interested in sports where the upper extremity is at the forefront.

Observational Registry of Patients With Rheumatoid Arthritis /Spondyloarthritis Using Biological or Targeted Synthetic DMARDs

In this study, investigators aimed to observe the examination findings, laboratory findings and drugs used in routine polyclinic controls of the participants using biological and targeted synthetic disease-modifying antirheumatic drug (DMARD) and the doses and side effects of these drugs. The aim of this registry is to evaluate the real-life data of participants receiving these medications. Analysis of treatment follow-up, drug changes, causes of change, treatment-related paradoxic / immune reactions, compliance with adult vaccination programs, nutritional profiles, presence of metabolic syndrome, fertility status, pregnancy outcomes, and vitamin D levels will be recorded in the outpatient clinic. Rheumatoid Arthritis Impact of Disease, Psoriatic Arthritis Impact of Disease (RAID and PSAID indexes), Work Productivity and Activity Impairment Questionnaire (WPAI), drug compliance, central sensitization and fall risk will be evaluated with verbal evaluation forms performed at policlinic controls in patients with spondyloarthritis and rheumatoid arthritis. It is planned to conduct scientific analyzes and publish on various subjects from the recorded information on this registration system. Patients using biological and targeted synthetic DMARD treatments are closely monitored and evaluated in many ways due to the risk profiles and various characteristics of the drugs. With this registry system, it is aimed to evaluate the real-life data of the participants using these drugs. Real-life data are very valuable in monitoring the disease and the drugs. Planned studies are: ROMATOID ARTHRITIS CLINICAL DEMOGRAPHIC ASSESSMENT / DISEASE EFFECT / DRUGS - SPONDYLOARTHRITIS CLINICAL DEMOGRAPHIC EVALUATION / DISEASE EFFECT / DRUGS - COMORBIDITY IN ROMATOID ARTHRITIS - COMORBIDITY IN SPONDYLOARTHRITIS - RE ACTIVITATION AND SAFETY MONITORING IN VIRAL HEPATITIS - TREATMENT PARADOXIC / IMMUNE REACTIONS (SYSTEMIC AUTOIMMUNE, ARTHRITIS, HEMATOLOGIC, NEUROLOGIC, PULMONARY, OPHTHALMOLOGICAL, INFLAMMATORY BOWEL DISEASE, LIVER, CUTANEOUS, OTHER) - WORK FORCE LOSS IN AXIAL SPONDYLOARTHRITIS - WORK FORCE LOSS IN PSORIATIC ARTHRITIS - WORK FORCE LOSS IN ROMATOID ARTHRITIS - PREGNANCY / FERTILITY OUTCOMES - TUBERCULOSIS MONITORING - DRUG SWITCH ANALYSIS - THROID DISEASE IN EARLY AND ESTABLISHED ROMATOID ARTHRITIS (AUTOIMMUNE THROIDITIS, MALIGNITY etc) - TREATMENT COMPLIANCE IN RHEUMATIC DISEASES - ADULT IMMUNIZATION PROGRAM IN RHEUMATIC DISEASES - METABOLIC SYNDROME ASSESSMENT - CARDIOVASCULAR RISK ASSESSMENT - FALL / FRACTURE AND RELATED VARIABLES IN RHEUMATIC DISEASES - VITAMIN D STATUS IN RHEUMATIC DISEASES - CENTRAL SENSITIZATION AND PAIN IN ROMATOID ARTHRITIS AND SPONDYLOARTROPATHIES AND RELATED VARIABLES The study is observational and there is no expected risk since no intervention is planned.

Prevalence of Hirsutism in Turkey: Data of The Dermatoendocrinology Study Group

Twenty-two provinces of Turkey's seven regions and 26 hospitals from these provinces will be included in the study. The number of samples was specified by the public health specialist on the 2018 census figures. The Turkish population consists of 80,810,525 people according to the data announced by the Turkish Statistical Institute in 2018. In order to determine the prevalence in Turkey, the sample size was calculated with a confidence interval of 99% and error margin of 1%, and the total number of individuals to be screened was designated as 5861. The number of patients to be screened via the clustering method weighted by regions was specified as 1800 for the Marmara Region, 750 for the Aegean Region, 744 for the Mediterranean Region, 568 for the Black Sea Region, 932 for the Central Anatolia Region, 434 for the Eastern Anatolia Region and 633 for the Southeastern Anatolia Region. The provinces that were thought to represent each region were selected via the cluster sampling method. During the study period, female patients aged between 18 and 45, who present to dermatology outpatient clinics, will be examined clinically until the number of patients designated for each study center is reached, and the hirsutism level of the patients diagnosed with hirsutism will be determined by using the modified Ferriman-Gallwey (mFG) scoring system. In this system, hair growth in nine regions (upper lip, chin, chest, upper back, lower back, upper abdomen, lower abdomen, upper arms and thighs) is graded between 0 and 4. And nine regions are scored between 0 (no terminal hairs) and 4 (excessive presence of terminal hairs). The score above 8 is considered hirsutism. The hirsutism family history, body mass index, menstrual cycle pattern, concomitant disease status (diabetes, hyperlipidemia, hypertension, thyroid disease), history of medication causing body hair growth, the acne presence and severity, presence and severity of androgenic alopecia, presence of seborrhea, presence and localization of acanthosis nigricans, presence of acrochordon, presence of hidradenitis suppurativa, presence of galactorrhea, presence of virilization symptoms and presence of cushingoid symptoms of all the examined patients will be investigated and recorded.