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London, Denmark Clinical Trials

A listing of London, Denmark clinical trials actively recruiting patients volunteers.

RESULTS

Found (22) clinical trials

ROS1 Targeting With Crizotinib in Advanced E-cadherin Negative ER Positive Lobular Breast Cancer or Diffuse Gastric Cancer Study

This clinical study is looking at whether a drug called crizotinib, which is used in some patients with lung cancer, is effective in a sub-type of breast cancer, called lobular breast cancer. As the majority of lobular breast cancers are oestrogen receptor positive (ER+ve), crizotinib will be combined with a ...

Phase

0.76 miles

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iSCORE: Immunotherapy Sequencing in COlon and REctal Cancer

This is a single-arm, single centre open-label, phase II interventional clinical trial of combination immunotherapy with Nivolumab and Relatlimab in mCRC. Participants with metastatic RAS/RAF WT colorectal cancer who have previously had a radiological response to standard first line therapy with FOLFIRI and Cetuximab but subsequently experienced progression of their ...

Phase

0.76 miles

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CLARITY Imaging Study

OCT image quality is necessary to provide accurate diagnostic information to ophthalmologists. The increasing resolution of imaging techniques will require ever more high standards of optical transmission through the cornea and tear film. Given that lubricant drops can improve optical transmission through the cornea, this study will attempt to quantify ...

Phase N/A

1.6 miles

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Identifying Biomarkers and Changes in Cerebrospinal Fluid Collected Pre and Post Spinal Cord Stimulation in Subjects Suffering From Chronic Refractory Pain Conditions

This is a single centre exploratory study in individuals suffering from chronic refractory pain to identify cellular, molecular and protein biomarkers within cerebrospinal fluid (CSF). The investigators aim to identify any form of correlation between biological content of CSF and pain/ spinal cord stimulator (SCS) therapy success. ` CSF will ...

Phase N/A

1.72 miles

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Efficacy and Safety of Cannabidiol Oral Solution (GWP42003-P CBD-OS) in Patients With Rett Syndrome

To evaluate the efficacy of cannabidiol oral solution (GWP42003-P, CBD-OS) in reducing symptom severity when compared with placebo, in patients with Rett syndrome.

Phase

1.85 miles

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A Study of the Safety of REN001 in Patients With Primary Mitochondrial Myopathy

The purpose of this study is to assess REN001 safety in subjects with primary mitochondrial myopathy

Phase

2.33 miles

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Trial of Ursodeoxycholic Acid (UDCA) for Parkinson's Disease: The "UP" Study

The primary aim of this study is to generate clinical data to examine the safety, tolerability & potential effectiveness of 48 weeks exposure to UDCA compared to placebo. Furthermore, it will determine the usefulness of novel objective readouts (namely the objective sensor based quantification of motor progression & 31P-MRS/imaging-based in ...

Phase

2.33 miles

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Oesophagectomy and Chest Wall and Respiratory Function

The study population consists of 50 healthy volunteers who have not received upper gastrointestinal surgery and 100 patients treated with surgery more than one year ago (50 open and 50 minimally invasive). Chest wall movement will be measured using a 3D optical motion system and the investigators will establish if ...

Phase N/A

2.71 miles

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Frailty in Vascular Patients Undergoing Surgery

Vascular surgical operations are major procedures with significant associated morbidity and mortality. Frailty is a major factor influencing surgical outcome, but the effect on morbidity/mortality and quality of life is poorly understood in vascular surgery. Activity levels play a significant role in frailty and in pre-intervention preparation. It is anticipated ...

Phase N/A

2.71 miles

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Noradrenergic Add-on Therapy With Guanfacine

There is evidence suggesting that both noradrenaline and acetylcholine have key roles to play in attention. Guanfacine acts by increasing levels of noradrenaline, a substance in the brain which is closely linked with attention, both noradrenaline levels and attentional performance have been shown to be reduced in Alzheimer's Disease. In ...

Phase

2.71 miles

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