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Copehagen South, Denmark Clinical Trials

A listing of Copehagen South, Denmark clinical trials actively recruiting patients volunteers.

Found (65) clinical trials

Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock Trial. VIPER-Sepsis (EudraCT no. 2016-000707-81)

Recently a great interest in the role of the endothelium in the pathophysiology of sepsis has been introduced. The endothelium is coated by a "thick" endothelial glycocalyx protecting it from becoming activated and prevents capillary leakage. The glycocalyx binds approximately 1-1.5 litres of the plasma portion of the circulating blood …

Phase

3.08 miles

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Pharmacological Properties of Salmeterol

The objective of the study is to help establish a urinary threshold for salmeterol on the World Anti-doping Agency prohibited list, to avoid supratherapeutic of this substance in competitive sports. Hence, there is no hypothesis as such.

Phase

3.08 miles

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The RECONSTRUCT Study - Reconstructing Disease Mechanisms in Asthma

Purpose and background Inhaled corticosteroids and asthma phenotypes Inhaled corticosteroid (ICS) is a cornerstone in the treatment of asthma. ICS acts locally in the airways through several pathways to limit inflammation, primarily through reduction of eosinophilic inflammation. In clinical practice however a substantial part of adult patients with asthma have …

Phase

3.08 miles

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Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation

Background Noninvasive ventilation (NIV) has been shown to improve survival in patients with chronic obstructive pulmonary disease (COPD), admitted with acute hypercapnic respiratory failure (AHRF); and NIV is recommended as a treatment of AHRF due to COPD. COPD patients having survived AHRF have a poor prognosis; Chu et al. have …

Phase

3.08 miles

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The Effect of Allergen Immunotherapy on Anti-viral Immunity in Patients With Allergic Asthma

1.1 Background Respiratory viral infections are the major cause of acute worsening of asthma. Importantly too, these infections may also predispose to bacterial infections. Patients with allergic asthma suffer from more frequent lower respiratory tract infections, more severe and longer lasting lower respiratory tract symptoms compared to healthy controls. Hence, …

Phase

3.08 miles

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Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics

The purpose of the study is to evaluate effect of benralizumab on structural and lung function changes in severe eosinophilic asthmatics. Changes will be assessed over 48 week treatment period in patients with persistent symptoms despite standard therapy of inhaled corticosteroids (ICS) plus long acting B2-agonist (LABA) with or without …

Phase

3.08 miles

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Effect of Combinations of Paracetamol Ibuprofen and Dexamethasone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty

Multimodal pain management is essential for recovery after surgery, aiming to target different pain mechanisms to minimize opioid usage and opioid-related adverse effects. Evidence for benefits and harms of various non-opioid analgesic combinations is, however, nearly non-existing, and large-scale trials are urgently needed. Recently, the investigators have demonstrated that combining …

Phase

3.08 miles

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Danish Trial of Beta Blocker Treatment After Myocardial Infarction Without Reduced Ejection Fraction

Aim: To determine whether long-term treatment with oral betablocker (BB) therapy after myocardial infarction (MI) in patient with no heart failure reduces the composite outcome of death from any cause, recurrent MI, unstable angina pectoris, stroke or heart failure. Intervention: BB therapy versus no therapy. Main Inclusion Criteria: Patient that …

Phase

3.08 miles

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Anti-viral Effects of Azithromycin in Patients With Asthma and COPD

Asthma and COPD are responsible for considerable global morbidity and healthcare costs, primarily driven by exacerbations, i.e. acute flare-ups. Hence there is a clear need for better interventions preventing exacerbations. A majority of exacerbations are driven by infections, and in particular viral infections. Importantly, the anti-viral defense in asthma and …

Phase

3.08 miles

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Study of the Efficacy of Early Intervention With Secukinumab 300 mg s.c. Compared to Narrow-band UVB in Patients With New-onset Moderate to Severe Plaque Psoriasis

The overall study population (Main Study and Mechanistic Sub-study) will consist of a total of 205 male and female patients aged between 18 and 40 years inclusive. Main Study The Main Study will be conducted in patients with new-onset moderate to severe plaque psoriasis not previously treated with any systemic …

Phase

3.92 miles

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