Torento, Canada Clinical Trials

A listing of Torento, Canada clinical trials actively recruiting patients volunteers.

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Found 10 clinical trials
Topotecan Episcleral Plaque for Treatment of Retinoblastoma

This single-arm, non-randomized, dose escalation phase I clinical trial will assess primarily the safety and secondarily the efficacy of episcleral topotecan in patients with active de novo or recurrent intraocular retinoblastoma in at least one eye following completion of first-line therapy.

platelet count
topotecan
renal function
intraocular retinoblastoma
calcium
Hospital for Sick Children
 (0.3 away) Contact site
  • 0 views
  • 18 Jul, 2021
  • 1 location
An Exploratory Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma and Non-Small Cell Lung Cancer With Liver Metastases (INTEGRATE)

This study is being done to look at how effective the drug, atezolizumab, with or without the drug bevacizumab, is for people with inoperable liver cancer or non-small lung cancer that has spread to the liver. This will be done by looking at the duration of time from starting the …

lung cancer
cancer
epidermal growth factor receptor
tyrosine
measurable disease
Princess Margaret Cancer Centre
 (0.5 away) Contact site
  • 0 views
  • 16 Jul, 2021
  • 1 location
Physiotherapy and Deep Brain Stimulation in Parkinson's Disease

Deep brain stimulation (DBS) is the most commonly performed surgical treatment for individuals with Parkinson's disease (PD). DBS typically works best to lessen motor symptoms such as stiffness, slowness, and tremor. Despite an overall improvement of these motor symptoms with DBS, past research failed to show an increase in community …

brain stimulation
motor symptoms
tremor
Movement Disorders Centre - Toronto Western Hospital
 (1.1 away) Contact site
  • 0 views
  • 21 Jul, 2021
  • 1 location
Fabry Cardiomyopathy: Identification of Early Myocardial Structural and Tissue Abnormalities Using Multiparametric MRI

This study will evaluate whether cardiac MRI T1 and T2 mapping improves our ability to detect early abnormalities in the heart in patients with Fabry disease and identify patients at increase risk of adverse events.

cardiomyopathy
  • 0 views
  • 21 Jul, 2021
  • 1 location
Emotion and Symptom-Focused Engagement Trial for Individuals With Acute Leukemia

The purpose of this study is to find out whether a novel manualized intervention, called Emotion and Symptom-focused Engagement (EASE), that combines psychological support with symptom screening plus triggered referral to early palliative care for symptom control, reduces psychological distress and physical symptom burden in individuals newly diagnosed with acute …

Kingston Health Sciences Centre
 (148.6 away) Contact site
  • 0 views
  • 20 Jul, 2021
  • +1 other locations
Feasibility of a Home Exercise Program to Manage Post-transplant Metabolic Syndrome

Post-transplant metabolic syndrome (PTMS) affects about 50% liver transplant (OLT) and 25% lung transplant (LTx) recipients at 12-18 months post-transplant. PTMS (comprised of glucose intolerance, obesity, hypercholesterolemia and hypertension) has been associated with increased risk for cardiovascular morbidity and long-term survival. Exercise studies in the early post-transplant period have shown …

diabetes
insulin resistance
insulin
hypertension
University Health Network - Toronto General Hospital
 (0.4 away) Contact site
  • 0 views
  • 21 Jul, 2021
  • 1 location
Stellate Ganglion Block for Major Depressive Disorder.

This is a feasibility study, to investigate a new treatment option for major depressive disorders by performing a Stellate Ganglion Block (SGB). A SGB is an injection of local anesthetic into the sympathetic nervous system (peripheral nervous system) located in the lower part of the neck, to relieve pain in …

  • 0 views
  • 22 Jul, 2021
  • 1 location
Development of Hardware and Software for Pulmonary Magnetic Resonance Imaging Using Inhaled Tracer Gases

This is a single centre study. The overarching hypothesis of this study is that MRI with inhaled tracer gases can provide high quality images of lung function to complement conventional 1H MRI. The study interventions do not affect the standard of care.

Hospital for Sick Children
 (0.3 away) Contact site
  • 0 views
  • 16 Jul, 2021
  • 1 location
Hyper-Personalized Medicine Using Patient Derived Xenografts (PDXovo) for Renal Cell Carcinoma Patients

The Investigators will use novel PDX (patient-derived xenograft) technology to form xenografts using material from metastatic renal cell carcinoma patients. Xenografts will be treated with a panel of drugs to determine which agent(s) yield the greatest anti-tumor effect on the xenograft.

cancer
kidney cancer
carcinoma
metastatic renal cell carcinoma
measurable disease
Odette Cancer Centre
 (4.7 away) Contact site
  • 0 views
  • 09 Jul, 2021
  • 1 location
Ultrasound for Assessment of Extubation Readiness

Preterm infants are at high-risk for the negative implications of both prolonged mechanical ventilation and extubation failure. Pre-extubation assessments of lung parenchyma and diaphragmatic function of these infants can be useful adjunctive tool for prediction of extubation readiness. The aim of this study is to assess the sensitivity and specificity …

Mount Sinai Hospital
 (0.5 away) Contact site
  • 0 views
  • 20 Jul, 2021
  • 1 location