St. John's, Canada Clinical Trials

A listing of St. John's, Canada clinical trials actively recruiting patients volunteers.

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Found 96 clinical trials
A Randomized, Open-Label, Phase 3 Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL) (EPCORE™DLBCL-1)

The drug that will be investigated in the study is an antibody, epcoritamab, also known as GEN3013 . Since the safety and tolerability of epcoritamab has already been studied in previous studies in humans, the main purpose of this study is to evaluate efficacy. To evaluate this, half of the …

CHU de Quebec-Universite Laval
 (864.8 away) Contact site
  • 2 views
  • 13 Oct, 2022
  • +235 other locations
TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer (TAILOR RT)

The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming …

core needle biopsy
immunostimulant
erbb2
aromatase inhibitor
mastectomy
Doctor H. Bliss Murphy Cancer Centre
 (1.6 away) Contact site
  • 768 views
  • 27 Oct, 2022
  • +339 other locations
A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects With Acute Coronary Syndrome (AEGIS-II)

This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events [MACE - cardiovascular (CV) death, myocardial infarction (MI), and stroke] in subjects with acute coronary syndrome (ACS) diagnosed with either ST-segment elevation …

arterial disease
diabetes
stroke
acute coronary syndrome
infarct
1240060 - Health Sciences Centre
 (1.6 away) Contact site
  • 1233 views
  • 27 Oct, 2022
  • +1646 other locations
A Randomized, Double-blind, Placebo-Controlled, Active-Comparator, Multicenter, Phase 3 Study of Brentuximab Vedotin or Placebo in Combination With Lenalidomide and Rituximab in Subjects With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL) (ECHELON-3)

Participants in this study will have diffuse large B-cell lymphoma (DLBCL) that has come back or not gotten better with treatment. The trial will study whether brentuximab vedotin plus two drugs works better to treat this type of cancer than the two drugs alone. Participants will be randomly assigned to …

avid
brentuximab
b-cell lymphoma
rituximab
lenalidomide
H. Bliss Murphy Cancer Centre / Eastern Regional Health Authority
 (1.5 away) Contact site
  • 6 views
  • 28 Oct, 2022
  • +120 other locations
Treatments for COVID-19: Canadian Arm of the SOLIDARITY Trial (CATCO)

This study is an adaptive, randomized, open-label, controlled clinical trial, in collaboration with countries around the world through the World Health Organization.

covid-19
lopinavir/ritonavir
hydroxychloroquine
remdesivir
SARS
Eastern Regional Health Authority
 (1.6 away) Contact site
  • 1533 views
  • 04 Oct, 2022
  • +44 other locations
PERC Health Canada COVID-19

Although there are several licensed vaccines for SAR-CoV-2 (COVID-19) in Canada, none of them are approved for use in children under the age of 12, leaving five million children under 12 years unvaccinated. There is a need to find methods of mass rapid point of care testing in unvaccinated populations …

IWK Health Centre
 (555.1 away) Contact site
  • 41 views
  • 04 Oct, 2022
  • +12 other locations
A Phase 3b, Multi Center, Open-label, Long-term Extension Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis

This study was created to provide subjects who complete Week 52 (end of Apremilast Extension Phase) of study CC-10004-PPSO-003 the option to continue to receive open-label apremilast therapy. The study will consist of up to 208 weeks of long-term treatment followed by an 8-week observational follow-up phase.

plaque psoriasis
cc-10004
hormonal contraception
cervical cap
option 2
Karma Clinical Trials
 (3.5 away) Contact site
  • 0 views
  • 14 Oct, 2022
  • +47 other locations
A Randomized, Active-Controlled, Efficacy Assessor-Blinded Study to Evaluate Pharmacokinetics, Safety and Efficacy of Risankizumab in Patients From 6 to Less Than 18 Years of Age With Moderate to Severe Plaque Psoriasis

Psoriasis is a chronic, systemic, inflammatory disease in which skin cells build up and develop thick, red and white scaly patches on the skin. There is an unmet medical need for effective treatment in pediatric patients and this study is being done to evaluate risankizumab in pediatric participants with moderate …

plaque psoriasis
risankizumab
ustekinumab
inflammatory disease
systemic therapy
Karma Clinical Trials /ID# 226177
 (3.5 away) Contact site
  • 100 views
  • 20 Oct, 2022
  • +46 other locations
Cardiac Sarcoidosis Randomized Trial (CHASM-CS-RCT)

Prospective randomized controlled trial comparing low dose Prednisone(or Prednisolone)/Methotrexate combination to standard dose Prednisone(or Prednisolone) in patients diagnosed with acute active clinically manifest cardiac sarcoidosis and not yet treated. The Investigators hypothesize that low dose Prednisone(or Prednisolone)/Methotrexate combination will be as effective as standard dose Prednisone(or Prednisolone), and result in …

methotrexate
pulmonary sarcoidosis
prednisone
cardiac sarcoidosis
lymphadenopathy
Eastern Health Health Sciences Centre
 (1.6 away) Contact site
  • 252 views
  • 27 Feb, 2022
  • +7 other locations
R vs L Lateral Decubitus Positioning in Colonoscopy

Colonoscopy continues to be the gold standard in detecting precancerous lesions in the colon. It relies on adequate visualization of the bowel wall to see and remove such lesions. Visualization is improved with luminal distention, and a multitude of studies have been done to determine ways to increase this luminal …

adenoma
Accepts healthy volunteers
luminal
Health Sciences Centre
 (1.6 away) Contact site
  • 15 views
  • 27 Apr, 2022
  • 1 location