Scarborough, Canada Clinical Trials

A listing of Scarborough, Canada clinical trials actively recruiting patients volunteers.

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Found 92 clinical trials
A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM AGILE) is an international, seamless Phase II/III response adaptive randomization platform trial designed to evaluate multiple therapies in newly diagnosed (ND) and recurrent GBM.

recurrent glioblastoma
recurrent disease
lomustine
MRI
temozolomide
Sunnybrook Health Sciences Centre
 (8.1 away) Contact site
  • 105 views
  • 19 Sep, 2021
  • +39 other locations
This Study Tests Whether BI 425809 Together With Brain Training Using a Computer Improves Mental Functioning in Patients With Schizophrenia

This is a study in adults with schizophrenia. The study tests whether a medicine called BI 425809 together with brain training improves mental abilities. Participants take study medication once a day for 12 weeks. At the start of the study, the participants are put into 2 groups. It is decided …

anticholinergics
antipsychotics
cognitive training
clozapine
antidepressants
Centre for Addiction and Mental Health (CAMH)
 (8.3 away) Contact site
  • 773 views
  • 18 Sep, 2021
  • +59 other locations
A Long-term Study to Evaluate Safety and Maintenance of Treatment Effect of LY3074828 in Participants With Moderate-to-Severe Plaque Psoriasis (OASIS-3)

The purpose of this study is to evaluate the long-term safety and maintenance of efficacy of mirikizumab in participants with moderate-to-severe plaque psoriasis.

plaque psoriasis
mirikizumab
Lynderm Research Inc
 (6.9 away) Contact site
  • 717 views
  • 12 Sep, 2021
  • +361 other locations
A Study of Apalutamide in Participants With High-Risk Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy

The purpose of this study is to determine if treatment with apalutamide plus androgen deprivation therapy (ADT) before and after radical prostatectomy (RP) with pelvic lymph node dissection (pLND) in participants with high-risk localized or locally advanced prostate cancer results in an improvement in pathological complete response (pCR) rate and …

adenocarcinoma of prostate
antiandrogen therapy
androgens
metastasis
adenocarcinoma
Sunnybrook Health Sciences Center
 (8.1 away) Contact site
  • 318 views
  • 19 Sep, 2021
  • +356 other locations
Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke

This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults without a prior myocardial infarction (MI) or stroke who are at high risk of a cardiovascular event.

diabetes
infarct
stroke
myocardial infarction
arterial disease
Corcare Cardiovascular Research
 (0.9 away) Contact site
  • 542 views
  • 19 Sep, 2021
  • +1332 other locations
Perioperative Pembrolizumab (MK-3475) Plus Cystectomy or Perioperative Pembrolizumab Plus Enfortumab Vedotin Plus Cystectomy Versus Cystectomy Alone in Cisplatin-ineligible Participants With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905/EV-303)

A global, randomized phase III study to evaluate perioperative pembrolizumab with radical cystectomy + pelvic lymph node dissection (RC+PLND) versus RC+PLND alone in cisplatin-ineligible patients with muscle-invasive bladder cancer (MIBC).

Sunnybrook Research Institute ( Site 0110)
 (8.1 away) Contact site
  • 95 views
  • 19 Sep, 2021
  • +200 other locations
Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients

The purpose of this study is to compare the efficacy and safety of 2 doses of crizanlizumab (5.0 mg/kg and 7.5 mg/kg) versus placebo in adolescent and adult sickle cell disease (SCD) patients with history of vaso-occlusive crisis (VOC) leading to healthcare visit.

priapism
chest syndrome
conjugated bilirubin
absolute neutrophil count
electrophoresis
Novartis Investigative Site
 (8.1 away) Contact site
  • 100 views
  • 19 Sep, 2021
  • +88 other locations
Comparing NUC-1031 Plus Cisplatin to Gemcitabine Plus Cisplatin in Patients With Advanced Biliary Tract Cancer

NuTide:121 compares NUC-1031 with gemcitabine, both in combination with cisplatin, in patients with previously untreated advanced biliary tract cancer. The primary hypotheses are: The combination of NUC-1031 plus cisplatin prolongs overall survival compared to the gemcitabine plus cisplatin standard of care The combination of NUC-1031 plus cisplatin increases overall response …

international normalized ratio
drainage
obstruction
gemcitabine
biliary tract cancer
Sunnybrook Research Institute
 (8.1 away) Contact site
  • 73 views
  • 19 Sep, 2021
  • +129 other locations
Metabolic Interventions to Resolve Non-alcoholic Steatohepatitis (NASH) With Fibrosis (MIRNA)

The study aims to evaluate two, orally administered, investigational agents - PF-06865571 (DGAT2 inhibitor) and the coadministration of PF-06865571 with PF-05221304 (ACC inhibitor). This study is specifically designed to evaluate the effect of a range of doses of DGAT2i alone, and DGAT2i + ACCi, on resolution of NASH or improvement …

steatohepatitis
fibrosis
hepatic fibrosis
North York General Hospital
 (6.5 away) Contact site
  • 72 views
  • 08 Sep, 2021
  • +350 other locations
A Phase 3 Study to Evaluate the Efficacy and Safety of CTP-543 in Adult Patients With Moderate to Severe Alopecia Areata (THRIVE-AA1)

This is a multi-center Phase 3 study to evaluate the safety and effectiveness of an investigational study drug (called CTP-543) in adults (18 years and older) who have 50% or greater scalp hair loss. The study is placebo-controlled, meaning that some patients entering the study will not receive active study …

areata alopecia
Lynderm Research Inc.
 (6.8 away) Contact site
  • 33 views
  • 19 Sep, 2021
  • +77 other locations