Scarborough, Canada Clinical Trials

A listing of Scarborough, Canada clinical trials actively recruiting patients volunteers.

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Found 91 clinical trials
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

The primary objective of this study is to evaluate the effectiveness (prevention of thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC) to background antiplatelet therapy in patients who develop new-onset post-operative atrial fibrillation (POAF) after isolated coronary artery bypass graft (CABG) surgery. All patients with a qualifying …

aspirin
thromboembolism
ticagrelor
coronary artery bypass graft
vitamin k
Sunnybrook Hospital
 (8.1 away) Contact site
  • 112 views
  • 19 Sep, 2021
  • +79 other locations
A Study of Mirvetuximab Soravtansine vs. Investigator's Choice of Chemotherapy in Platinum-Resistant Advanced High-Grade Epithelial Ovarian Primary Peritoneal or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression

This Phase 3 study is designed to compare the efficacy and safety of mirvetuximab soravtansine vs. investigator's choice chemotherapy in patients with platinum-resistant high-grade epithelial ovarian cancer, primary peritoneal, or fallopian tube cancer, whose tumors express a high-level of FR. Patients will be, in the opinion of the Investigator, appropriate …

hormone therapy
immunostimulant
cancer
cytotoxic chemotherapy
platelet count
Sunnybrook Health Sciences Center
 (8.1 away) Contact site
  • 88 views
  • 10 Sep, 2021
  • +156 other locations
Assessing the Impact of Lipoprotein (a) Lowering With TQJ230 on Major Cardiovascular Events in Patients With CVD

This is a pivotal phase 3 study designed to support an indication for the reduction of cardiovascular risk in patients with established CVD and elevated Lp(a)

Novartis Investigative Site
 (8.1 away) Contact site
  • 143 views
  • 19 Sep, 2021
  • +578 other locations
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the …

Sunnybrook Health Sciences Centre
 (8.1 away) Contact site
  • 7 views
  • 15 Sep, 2021
  • +38 other locations
Study to Assess the Efficacy and Safety of Brolucizumab 6mg Compared to Aflibercept 2 mg in a Treat-to-control Regimen (TALON)

The study is a 64-week randomized, double-masked, multi-center, active-controlled, two-arm study in patients with nAMD (neovascular age related macular degeneration) who have not previously received anti-VEGF (vascular endothelial growth factor) treatment. Patients who consent will undergo screening assessments to evaluate their eligibility based on the inclusion and exclusion criteria.

optical coherence tomography
corrected visual acuity
neovascularization
bevacizumab
retinopathy
Novartis Investigative Site
 (8.1 away) Contact site
  • 30 views
  • 18 Sep, 2021
  • +135 other locations
A Safety and Efficacy Study of Oral Venetoclax Tablets and Injectable Azacitidine Versus Best Supportive Care as Maintenance Therapy in Adult Participants With Acute Myeloid Leukemia in First Remission After Conventional Chemotherapy to Evaluate Improvement in Relapse-Free Survival

The main objective of this study is to evaluate safety and efficacy of venetoclax in combination with azacitidine (AZA) and best supportive care (BSC) compared to BSC as maintenance therapy in adult participants with acute myeloid leukemia (AML) in first remission after conventional chemotherapy. This study will be conducted in …

remission
venetoclax
azacitidine
cancer
consolidation chemotherapies
Sunnybrook Health Sciences Ctr /ID# 215681
 (8.1 away) Contact site
  • 40 views
  • 15 Sep, 2021
  • +306 other locations
A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)

The primary objective of this study is to compare belzutifan to everolimus with respect to progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as assessed by Blinded Independent Central Review (BICR) and to compare everolimus with respect to overall survival (OS). The hypothesis is …

clear cell renal cell carcinoma
carcinoma
solid tumour
advanced renal cell carcinoma
growth factor
Sunnybrook Research Institute ( Site 0153)
 (8.1 away) Contact site
  • 168 views
  • 19 Sep, 2021
  • +182 other locations
Efficacy and Safety Study of Oral Edaravone Administered in Subjects With ALS

To evaluate and compare the efficacy of two dosing regimens of oral edaravone in subjects with amyotrophic lateral sclerosis (ALS) based on the change in ALS Functional Rating ScaleRevised (ALSFRS-R) score from baseline up to Week 48:

edaravone
primary lateral sclerosis
Odette Cancer Center-Sunnybrook Health Sciences Centre
 (8.1 away) Contact site
  • 0 views
  • 19 Sep, 2021
  • +56 other locations
Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure Obesity and Type 2 Diabetes

This study will look at how participants' daily life is affected by their heart failure. The study will also look at the change in participants' body weight. This study will compare the effect of semaglutide (a new medicine) compared to "dummy" medicine on body weight and heart failure symptoms. Participants …

Novo Nordisk Investigational Site
 (2.4 away) Contact site
  • 7 views
  • 19 Sep, 2021
  • +59 other locations
Study to Evaluate Adverse Events and Change in Disease Activity in Adult and Adolescent Participants With Acute Hepatitis C Virus (HCV) Infection on Treatment With Oral Tablets of Glecaprevir (GLE)/Pibrentasvir (PIB)

Hepatitis C Virus (HCV) infection is a global health problem. HCV mainly affects liver cells and causes the liver to become inflamed and damaged. This study will evaluate how safe and effective glecaprevir/pibrentasvir (GLE/PIB) is in adult and adolescent participants with acute HCV infection. GLE/PIB is an approved drug for …

South Riverdale Community Health Centre /ID# 228098
 (9.6 away) Contact site
  • 0 views
  • 19 Sep, 2021
  • +56 other locations