Saitn John, Canada Clinical Trials

A listing of Saitn John, Canada clinical trials actively recruiting patients volunteers.

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Found 28 clinical trials
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A Randomized Phase 3 Study of Sitravatinib in Combination with Nivolumab Versus Docetaxel in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer with Disease Progression On or After Platinum-Based Chemotherapy and Checkpoint Inhibitor Therapy (SAPPHIRE)

This is an open-label, randomized (1:1), multicenter, Phase 3 clinical trial evaluating the safety and efficacy of nivolumab in combination with investigational agent sitravatinib compared to docetaxel in patients with advanced non-squamous NSCLC who have previously experienced radiographic disease progression on or after treatment with platinum-based chemotherapy in combination with …

advanced lung cancer
nivolumab
platinum-based chemotherapy
cancer chemotherapy
squamous non-small cell lung cancer
Saint John Regional Hospital
 (2.1 away) Contact site
  • 213 views
  • 28 Jul, 2021
  • +188 other locations
Effect of Sodium Zirconium Cyclosilicate on Arrythmia-related Cardiovascular Outcomes in Participants on Chronic Hemodialysis With Recurrent Hyperkalemia (DIALIZE-Outcomes)

The purpose of this study is to evaluate the effect of Sodium Zirconium Cyclosilicate (SZC) on arrhythmia-related cardiovascular outcomes in participants on chronic hemodialysis with recurrent hyperkalemia.

Research site
 (1.2 away) Contact site
  • 0 views
  • 02 Aug, 2021
  • +252 other locations
Phase III Study to Determine the Efficacy of Durvalumab in Combination With Chemotherapy in Completely Resected Stage II-III Non-small Cell Lung Cancer (NSCLC)

This is a Phase III, randomized, parallel-arm, placebo controlled, double blind, multicenter study assessing the efficacy and safety of durvalumab versus placebo following SoC chemotherapy in patients with completely resected stage II-III NSCLC who are MRD+ post surgery

cancer chemotherapy
lung carcinoma
durvalumab
Research Site
 (1.2 away) Contact site
  • 102 views
  • 04 Aug, 2021
  • +245 other locations
Phase III Study to Determine Efficacy of Durvalumab in Stage II-III Non-small Cell Lung Cancer (NSCLC) After Curative Intent Therapy.

This is a Phase III double-blind, placebo-controlled study of Durvalumab versus Placebo in patients with stage II-III NSCLC who are MRD-positive following curative intent therapy.

lung carcinoma
durvalumab
Research site
 (1.2 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +186 other locations
Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction

This study will assess whether an implantable defibrillator will increase the likelihood of survival in patients who have had a heart attack in the prior 5 years, have abnormal test results from a 24 hour heart monitor, and who have low normal heart function.

revascularisation
ace inhibitor
coronary artery bypass graft
coronary angioplasty
beta blockers
New Brunswick Heart Centre
 (0.3 away) Contact site
  • 258 views
  • 21 Jan, 2021
  • +82 other locations
Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine as First-Line Treatment for Participants With Higher-Risk Myelodysplastic Syndromes (HR MDS) Chronic Myelomonocytic Leukemia (CMML) or Low-Blast Acute Myelogenous Leukemia (AML)

The purpose of this study is to determine whether the combination of pevonedistat and azacitidine improves event-free survival (EFS) when compared with single-agent azacitidine. (An event is defined as death or transformation to AML in participants with MDS or CMML, whichever occurs first, and is defined as death in participants …

induction chemotherapy
myelodysplastic syndromes
myeloid leukemia
pevonedistat
azacitidine
Saint John Regional Hospital
 (1.2 away) Contact site
  • 341 views
  • 24 Jul, 2021
  • +319 other locations
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer

The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming …

adjuvant chemotherapy
core needle biopsy
aromatase inhibitor
hormone therapy
sentinel lymph node biopsy
Atlantic Health Sciences Corporation-Saint John Regional Hospital
 (1.2 away) Contact site
  • 598 views
  • 25 Jul, 2021
  • +318 other locations
Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance

The ascending aorta conducts blood from the heart to the rest of the body. The ascending aorta can become enlarged, and the risk of tearing and rupturing becomes higher with larger aorta. When the ascending aorta tears or ruptures, the risk dying is high even if surgery is done as …

Horizon Health Network
 (1.3 away) Contact site
  • 68 views
  • 29 Jun, 2021
  • +20 other locations
A Phase 3 Efficacy Safety and Tolerability Study of Zolbetuximab (Experimental Drug) Plus mFOLFOX6 Chemotherapy Compared to Placebo Plus mFOLFOX6 as Treatment for Gastric and Gastroesophageal Junction (GEJ) Cancer

A study of zolbetuximab (IMAB362) plus mFOLFOX6 versus placebo plus mFOLFOX6 in subjects with Claudin 18.2 positive, HER2-negative, locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma. Why is this study being done? SPOTLIGHT is a new clinical study for adult patients who have any of: advanced unresectable gastric …

Site CA15009
 (1.2 away) Contact site
  • 484 views
  • 23 Jul, 2021
  • +237 other locations
Zibotentan and Dapagliflozin for the Treatment of CKD (ZENITH-CKD Trial)

The purpose of the study is to assess efficacy, safety and tolerability of treatment with zibotentan and dapagliflozin in combination and alone, compared with placebo in participants with chronic kidney disease (CKD) with estimated glomerular filtration rate (eGFR) between 20 and 60 mL/min/1.73^2.

Research site
 (1.2 away) Contact site
  • 1 views
  • 13 Jul, 2021
  • +149 other locations