Saint John, Canada Clinical Trials

A listing of Saint John, Canada clinical trials actively recruiting patients volunteers.

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Found 68 clinical trials
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer (TAILOR RT)

The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming …

immunostimulant
carcinoma
core needle biopsy
aromatase inhibitor
sentinel lymph node biopsy
Atlantic Health Sciences Corporation-Saint John Regional Hospital
 (1.2 away) Contact site
  • 760 views
  • 27 Jul, 2022
  • +325 other locations
Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery (TRICS-IV)

TRICS-IV is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in moderate to high risk patients who are 65 years of age or younger undergoing cardiac surgery on cardiopulmonary bypass, using a superiority trial design.

cardiopulmonary bypass
Saint John Regional Hospitall
 (1.2 away) Contact site
  • 0 views
  • 12 Mar, 2022
  • +5 other locations
Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer (CHALLENGE)

RATIONALE: Participating in a physical activity program designed to increase free time physical activity and receiving written health education materials may influence the chance of cancer recurring as well as impact on physical fitness, psychological well-being and the quality of life of patients who have undergone surgery and chemotherapy for …

fatigue assessment and management
immunomodulators
fatigue
exercise intervention
x-rays
Regional Health Authority B, Zone 2
 (1.2 away) Contact site
  • 578 views
  • 23 Jan, 2022
  • +47 other locations
A Phase 3, Multicenter, Open-Label, Single-Arm Study of Bentracimab (PB2452) in Ticagrelor-Treated Patients With Uncontrolled Major or Life-Threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure (REVERSE-IT Trial) (REVERSE-IT)

This is a multi-center, open-label, prospective single-arm study of reversal of the antiplatelet effects of ticagrelor with bentracimab (PB2452) in patients who present with uncontrolled major or life-threatening bleeding or who require urgent surgery or invasive procedure. Approximately 200 patients will be enrolled from approximately 200 centers in North America, …

ticagrelor
haemostasis
postoperative hemorrhage
blood transfusion
coronary artery bypass graft
Saint John Regional Hospital
 (1.2 away) Contact site
  • 64 views
  • 15 Sep, 2022
  • +60 other locations
Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the Prostate (DASL-HiCaP)

The purpose of this study is to determine the effectiveness of darolutamide as part of adjuvant androgen deprivation therapy (ADT) with a luteinising hormone releasing hormone analogue (LHRHA) in men having radiation therapy for localised prostate cancer at very high risk of recurrence.

gonadorelin
luteinizing hormone-releasing hormone agonist
external beam radiotherapy
neutrophil count
immunological adjuvant
Regional Health Authority B, Zone 2 Saint John Regional Hospital
 (1.2 away) Contact site
  • 73 views
  • 20 Jul, 2022
  • +71 other locations
Phase III Radium 223 mCRPC-PEACE III (PEACE III)

The primary objective of the trial is to assess if upfront combination of enzalutamide and Ra223 improves radiological progression-free survival (rPFS1) compared to enzalutamide single agent in CRPC patients metastatic to bone

bone scan
bilateral orchidectomy
luteinizing hormone
diphosphonates
antiandrogen therapy
Saint John Regional Hospital
 (1.2 away) Contact site
  • 514 views
  • 03 Jul, 2022
  • +61 other locations
A Phase II Study of Durvalumab

I238A: The purpose of this study is to find out what effects being treated with durvalumab has on cancer. The researchers doing this study also want to evaluate if prednisone (a type of steroid), when given together with durvalumab, can reduce any side effects. I238B: The purpose of this study …

targeted therapy
solid tumour
pd-l1
x-rays
cancer treatment
Regional Health Authority B, Zone 2
 (1.2 away) Contact site
  • 1 views
  • 21 Jul, 2022
  • +6 other locations
Virtual Reality Training to Increase Rehabilitative Exercise in Seniors

Seniors are at risk for reduced independence and lowered quality of life after injury or illness. Gains in strength, stamina, balance, cardiovascular fitness and confidence resulting from regular exercise can help seniors to maintain (or improve) their functional ability, independence, and quality of life. However, seniors experience many barriers to …

regular exercise
Rocmaura Nursing Home
 (0.5 away) Contact site
  • 19 views
  • 12 May, 2022
  • +4 other locations
Decompression vs. Fusion for Stable Degenerative Spondylolisthesis

The purpose of this study is to assess the feasibility of a full-scale multicenter randomized, controlled trial comparing the effectiveness of two surgical treatments for a condition associated with lumbar spinal stenosis called degenerative lumbar spondylolisthesis. Both treatments are currently used, but individual surgeons use different selection criteria for each …

spinal stenosis
spondylolisthesis
stenosis
lumbar spinal stenosis
spinal fusion
Horizon Health Network
 (1.3 away) Contact site
  • 746 views
  • 24 Jan, 2021
  • +13 other locations
A Phase 2, Randomized, Placebo-Controlled, Double-Blind, Adaptive, Parallel Group Clinical Study to Evaluate the Efficacy and Safety of RMC-035 in Subjects at High Risk for Acute Kidney Injury Following Open-Chest Cardiac Surgery (AKITA)

This study evaluates RMC-035 compared to placebo for the prevention of acute kidney injury (AKI) in subjects who are at high risk for AKI following cardiac surgery. Half of the subjects will receive RMC-035 and the other half will receive placebo.

glomerular filtration rate
cardiopulmonary bypass
St. John Regional Hospital
 (1.2 away) Contact site
  • 0 views
  • 16 Sep, 2022
  • +14 other locations