Ottowa, Canada Clinical Trials

A listing of Ottowa, Canada clinical trials actively recruiting patients volunteers.

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Found 119 clinical trials
Evaluation of Efficacy and Safety of Neoadjuvant Treatment With Pamrevlumab in Combination With Chemotherapy (Either Gemcitabine Plus Nab-paclitaxel or FOLFIRINOX) in Locally Advanced Pancreatic Cancer

This is a Phase 3, randomized, double-blind trial to evaluate the efficacy and safety of neoadjuvant treatment with pamrevlumab or placebo in combination with either gemcitabine plus nab-paclitaxel (G/NP) or FOLFIRINOX in the treatment of locally advanced, unresectable pancreatic cancer subjects.

The Ottawa Hospital
 (2.3 away) Contact site
  • 8 views
  • 19 Sep, 2021
  • +87 other locations
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer

The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming …

core needle biopsy
aromatase inhibitor
carcinoma
adjuvant chemotherapy
sentinel lymph node biopsy
Ottawa Hospital and Cancer Center-General Campus
 (2.7 away) Contact site
  • 598 views
  • 19 Sep, 2021
  • +323 other locations
Stress Hydrocortisone In Pediatric Septic Shock

SHIPSS is a multi-institutional, prospective, controlled, randomized, double-blinded interventional trial that will examine the potential benefits and risks of adjunctive hydrocortisone prescribed for children with fluid and vasoactive-inotropic refractory septic shock. It is hypothesized that adjunctive hydrocortisone will significantly reduce the proportion of children with poor outcomes, defined as death …

continuous infusion
inotropic agent
antimicrobial agent
norepinephrine
Children's Hospital of Eastern Ontario
 (2.5 away) Contact site
  • 18 views
  • 07 Sep, 2021
  • +66 other locations
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes

This study will look at the long-term effects of semaglutide (active medicine) on diabetic eye disease when compared to placebo (dummy medicine). The study will be performed in people with type 2 diabetes. Participants will either get semaglutide or placebo in addition to their diabetes medicines - which treatment the …

hypoglycemic agents
semaglutide
Novo Nordisk Investigational Site
 (2.2 away) Contact site
  • 581 views
  • 19 Sep, 2021
  • +237 other locations
Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity

The researchers are doing the study to see if semaglutide may reduce the risk of having cardiovascular events in patients with overweight or obesity and with prior cardiovascular disease. The participant will either get semaglutide (active medicine) or placebo ("dummy" medicine). Which treatment the participants get is decided by chance. …

cardiovascular disease
body mass index
overweight or obesity
Novo Nordisk Investigational Site
 (9.3 away) Contact site
  • 7777 views
  • 19 Sep, 2021
  • +1166 other locations
Efficacy and Safety Study of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low Low or Intermediate Risk Myelodysplastic Syndromes (MDS) in ESA Na ve Subjects Who Require Red Blood Cell Transfusions

The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements. This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept (ACE-536) …

cancer
anemia
blood transfusion
erythropoietin
bone marrow procedure
Ottawa General Hospital
 (2.7 away) Contact site
  • 294 views
  • 19 Sep, 2021
  • +292 other locations
Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treated c-Met+ Non-Small Cell Lung Cancer

This study is designed to identify the target Non-Small Cell Lung Cancer (NSCLC) population(s) that over express c-Met (c-Met+) best suited for telisotuzumab vedotin therapy in the second line or third line setting (Stage 1) and then to expand the group(s) to further evaluate efficacy in the selected population(s) (Stage …

cancer treatment
systemic therapy
growth factor
stage iv non-small cell lung cancer
tyrosine
The Ottawa Hospital /ID# 205579
 (2.7 away) Contact site
  • 119 views
  • 19 Sep, 2021
  • +380 other locations
A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis

The purpose of this study is to evaluate the efficacy and safety of mirikizumab as maintenance therapy in participants who completed prior 12-week induction study AMAN (NCT03518086).

mirikizumab
endoscopy
The Ottawa Hospital
 (2.7 away) Contact site
  • 386 views
  • 12 Sep, 2021
  • +912 other locations
A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer

This study is being done to see if tucatinib with ado-trastuzumab emtansine (T-DM1) works better than T-DM1 alone to help patients who have a specific type of breast cancer called HER2 positive breast carcinoma. The breast cancer in this study is either metastatic (spread into other parts of the body) …

estrogen receptor
breast carcinoma
cancer
brain metastases
HER2
University of Ottawa / Ottawa General Hospital
 (2.7 away) Contact site
  • 24 views
  • 19 Sep, 2021
  • +236 other locations
A Study of Osimertinib With or Without Chemotherapy as 1st Line Treatment in Patients With Mutated Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer (FLAURA2)

The reason for the study is to find out if an experimental combination of an oral medication called osimertinib (TAGRISSO) when used in combination with chemotherapy is more effective than giving osimertinib alone for the treatment of locally advanced or metastatic non-small cell lung cancer. Some lung cancers are due …

cancer treatment
non-squamous non-small cell lung cancer
tyrosine
pemetrexed
lung carcinoma
Research Site
 (2.7 away) Contact site
  • 811 views
  • 12 Sep, 2021
  • +173 other locations