Ottowa, Canada Clinical Trials

A listing of Ottowa, Canada clinical trials actively recruiting patients volunteers.

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Found 118 clinical trials
Ribavirin to Enhance Hepatitis B Virus Nucleotide Analog Antiviral Activity

Hepatitis B virus (HBV) leads to life-threatening disease like liver failure and liver cancer. For most, a cure is unattainable as current HBV antiviral therapy (using nucleoside analogues) are not able to clear the virus from their liver. While HBV treatments are typically administered alone (monotherapy), this study will explore …

hepatitis d
nucleoside analog
liver failure
hepatitis b surface
Ottawa Hospital Research Institute
 (2.7 away) Contact site
  • 23 Sep, 2021
  • +1 other locations
Hyperbaric Versus Normobaric Oxygen Therapy for COVID-19 Patients

At least 1 in 6 COVID-19 patients admitted to hospital to receive extra oxygen will die of complications. In patients with COVID-19, invasive treatment such as mechanical ventilation (e.g. breathing with a machine) is associated with a 50% increased risk of death. Invasive treatments use a lot of healthcare resources …

The Ottawa Hospital
 (2.3 away) Contact site
  • 24 Sep, 2021
  • 1 location
A Study to Evaluate the Mechanism of Action of Ruxolitinib Cream in Subjects With Vitiligo (TRuE-V MOA)

The purpose of the study is to evaluate the Mechanism Of Action (MOA) of ruxolitinib cream in vitiligo by assessing the change in biomarkers.

skin biopsy
Jbr Research Inc
 (2.5 away) Contact site
  • 26 Sep, 2021
  • +3 other locations
A Study to Evaluate Enfortumab Vedotin in Subjects With Previously Treated Locally Advanced or Metastatic Malignant Solid Tumors (EV-202)

The primary purpose of this study is to determine the antitumor activity of enfortumab vedotin as measured by confirmed objective response rate (ORR). This study will also assess other measures of antitumor activity; overall survival (OS); as well as the safety and tolerability of enfortumab vedotin.

Site CA15003
 (2.7 away) Contact site
  • 27 Sep, 2021
  • +40 other locations
Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events [MACE - cardiovascular (CV) death, myocardial infarction (MI), and stroke] in subjects with acute coronary syndrome (ACS) diagnosed with either ST-segment elevation …

percutaneous coronary intervention
acute coronary syndrome
myocardial infarction
1240077 - Ottawa Heart Institute
 (2.2 away) Contact site
  • 26 Sep, 2021
  • +3432 other locations
Duration of Anti-PD-1 Therapy in Metastatic Melanoma

The purpose of this study is to compare the effects on patients with metastatic melanoma of taking a government approved and paid-for PD-1 inhibitor intermittently, with taking the same type of agent continuously. Researchers want to see if the two ways of giving this type of treatment work equally well …

Ottawa Hospital Research Institute
 (2.7 away) Contact site
  • 22 Sep, 2021
  • +30 other locations
Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma

This randomized phase III trial studies how well combination chemotherapy (vincristine sulfate, dactinomycin, cyclophosphamide alternated with vincristine sulfate and irinotecan hydrochloride or vinorelbine) works compared to combination chemotherapy plus temsirolimus in treating patients with rhabdomyosarcoma (cancer that forms in the soft tissues, such as muscle), and has an intermediate chance …

neutrophil count
alveolar rhabdomyosarcoma
cancer chemotherapy
glomerular filtration rate
Children's Hospital of Eastern Ontario
 (2.5 away) Contact site
  • 26 Sep, 2021
  • +290 other locations
A Study of ARRY-371797 (PF-07265803) in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation

This is a randomized, double-blind, placebo-controlled study in patients with dilated cardiomyopathy (DCM) due to a mutation of the gene encoding the lamin A/C protein (LMNA). The study will further evaluate a dose level of study drug (ARRY-371797) that has shown preliminary efficacy and safety in this patient population. After …

implantable cardioverter-defibrillators
cardiac resynchronization therapy
walk test
c protein
dilated cardiomyopathy
Array BioPharma Investigative Site
 (2.2 away) Contact site
  • 26 Sep, 2021
  • +261 other locations
This Study Aims to Find the Best Dose of BI 907828 in Patients With Different Types of Advanced Cancer (Solid Tumors)

This study is open to adults with different types of advanced cancer (solid tumours). The purpose of this study is to find out the highest dose of BI 907828 the participants can tolerate. In the second part, the study also tests whether BI 907828 makes tumours shrink. In this study, …

solid neoplasm
advanced cancer
primary cancer
measurable disease
The Ottawa Hospital
 (2.7 away) Contact site
  • 18 Sep, 2021
  • +6 other locations
The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial

MICS CABG (Minimally invasive coronary surgery), where coronary artery bypass grafting (CABG) is completed through a small incision over the left chest, has evolved to become a safe and less invasive alternative to conventional sternotomy CABG. Several observational studies have suggested significantly shorter time to return to physical activity for …

bypass graft
angina pectoris
arterial disease
Division of Cardiac Surgery, University of Ottawa Heart Institute
 (2.2 away) Contact site
  • 23 Sep, 2021
  • +12 other locations