Nepean, Canada Clinical Trials

A listing of Nepean, Canada clinical trials actively recruiting patients volunteers.

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Found 190 clinical trials
A Phase 1 Open Label, Multi-Arm, Multicenter Study of MK-4830 as Monotherapy and in Combination With Pembrolizumab for Participants With Advanced Solid Tumors

This study consists of several parts: dose escalation, dose expansion, dose expansion in Chinese participants residing in China, and coformulation. Dose escalation is to evaluate the safety, tolerability, and preliminary efficacy of MK-4830 monotherapy administration (Arms A and B) and in combination with pembrolizumab (Arm C). Dose expansion is to …

EGFR
carcinoma
HER2
dental caries
cancer chemotherapy
The Ottawa Hospital ( Site 0031)
 (5.8 away) Contact site
  • 237 views
  • 27 Oct, 2022
  • +22 other locations
A Multicenter, Single-Arm, Open-Label, Extension, Rollover Study To Evaluate The Long-Term Safety And Efficacy Of Ocrelizumab In Patients With Multiple Sclerosis (OLERO)

This is a Phase IIIb, single-arm, multicenter, OLE study. Participants receiving ocrelizumab as an investigational medicinal product (IMP) in a Roche sponsored Parent study who continue to receive ocrelizumab or are in safety follow-up at the time of the closure of their respective Parent study (WA21092, WA21093 or WA25046) are …

ocrelizumab
Clinique Neuro Outaouais
 (7.5 away) Contact site
  • 0 views
  • 27 Oct, 2022
  • +68 other locations
TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer (TAILOR RT)

The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming …

core needle biopsy
tamoxifen
carcinoma
erbb2
HER2
Ottawa Hospital and Cancer Center-General Campus
 (5.8 away) Contact site
  • 768 views
  • 27 Oct, 2022
  • +339 other locations
Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR): A Phase II Basket Trial (CAPTUR)

Cancer drugs which target the effects of abnormal gene changes are called 'targeted therapies'. This study, called PM.1 or CAPTUR, will include some targeted therapies that are currently available. The purpose of this study is to find out what are the effects on a patient and their cancer when they …

bone marrow procedure
multiple myeloma
neutrophil count
nivolumab
solid tumour
Ottawa Hospital Research Institute
 (5.8 away) Contact site
  • 63 views
  • 27 Oct, 2022
  • +9 other locations
A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects With Acute Coronary Syndrome (AEGIS-II)

This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events [MACE - cardiovascular (CV) death, myocardial infarction (MI), and stroke] in subjects with acute coronary syndrome (ACS) diagnosed with either ST-segment elevation …

infarct
acute coronary syndrome
percutaneous coronary intervention
arterial disease
diabetes
1240077 - Ottawa Heart Institute
 (4.1 away) Contact site
  • 1233 views
  • 27 Oct, 2022
  • +1646 other locations
A Phase 3, Randomized, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Stereotactic Body Radiotherapy (SBRT) With or Without Pembrolizumab (MK-3475) in Participants With Unresected Stages I or II Non Small Cell Lung Cancer (NSCLC) (KEYNOTE-867)

The purpose of this study is to assess the efficacy and safety of stereotactic body radiotherapy (SBRT) plus pembrolizumab (MK-3475) in the treatment of adult participants with unresected stage I or II (Stage IIB N0, M0) non-small cell lung cancer (NSCLC). The primary study hypotheses are: SBRT plus pembrolizumab prolongs …

stereotactic body radiation therapy
mk-3475
lung carcinoma
pembrolizumab
The Ottawa Hospital ( Site 0104)
 (5.8 away) Contact site
  • 121 views
  • 27 Oct, 2022
  • +135 other locations
A Phase Ia/Ib Dose-Escalation and Dose-Expansion Study Evaluating the Safety, Pharmacokinetics, and Activity of GDC-6036 as a Single Agent and in Combination With Other Anti-cancer Therapies in Patients With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

This is a Phase I dose-escalation and dose-expansion study that will evaluate the safety, pharmacokinetics (PK), and preliminary activity of GDC-6036 in patients with advanced or metastatic solid tumors with a KRAS G12C mutation.

cetuximab
ki-ras
erlotinib
bevacizumab
atezolizumab
Ottawa Hospital
 (4.0 away) Contact site
  • 92 views
  • 27 Oct, 2022
  • +58 other locations
A Randomized Phase 3 Study of MRTX849 in Combination With Cetuximab Versus Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation With Disease Progression On or After Standard First-Line Therapy

Study 849-010 is an open-label, randomized Phase 3 clinical trial comparing the efficacy of MRTX849 administered in combination with cetuximab versus chemotherapy in the second-line treatment setting in patients with CRC with KRAS G12C mutation.

Research Site
 (6.1 away) Contact site
  • 0 views
  • 28 Oct, 2022
  • +193 other locations
A Randomized, Double-blind, Placebo-Controlled, Active-Comparator, Multicenter, Phase 3 Study of Brentuximab Vedotin or Placebo in Combination With Lenalidomide and Rituximab in Subjects With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL) (ECHELON-3)

Participants in this study will have diffuse large B-cell lymphoma (DLBCL) that has come back or not gotten better with treatment. The trial will study whether brentuximab vedotin plus two drugs works better to treat this type of cancer than the two drugs alone. Participants will be randomly assigned to …

lenalidomide
avid
b-cell lymphoma
brentuximab
measurable disease
University of Ottawa / Ottawa General Hospital
 (5.8 away) Contact site
  • 6 views
  • 28 Oct, 2022
  • +120 other locations
EF-32: Pivotal, Randomized, Open-Label Study of Optune® (Tumor Treating Fields, 200kHz) Concomitant With Radiation Therapy and Temozolomide for the Treatment of Newly Diagnosed Glioblastoma (EF-32)

To test the effectiveness and safety of Optune® given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM patients, compared to radiation therapy and temozolomide alone. In both arms, Optune® and maintenance temozolomide are continued following radiation therapy.

MRI
complete resection
tumor treating fields therapy
tumor progression
gross total resection
The Ottawa Hospital Cancer Centre
 (5.8 away) Contact site
  • 72 views
  • 29 Oct, 2022
  • +100 other locations