Montreal, Canada Clinical Trials

A listing of Montreal, Canada clinical trials actively recruiting patients volunteers.

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Found 315 clinical trials
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COMMANDS - Myelodysplastic Syndromes (MDS) - ACE536-MDS-002 – Canada  

The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements.   This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept …

epoetin alfa
Sir Mortimer B Davis Jewish General Hospital
 (3.0 away)
  • 33 views
  • 03 Aug, 2021
  • +9 other locations
A Study of Biomarker-Directed Pembrolizumab (MK-3475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer (MK-3475-495/KEYNOTE-495)

This study will investigate the utility of biomarker-based triage for study participants with advanced non-small cell lung cancer (NSCLC) without prior systemic therapy. Study participants within groups defined by a biomarker-based classifier (gene expression profile [GEP] and tumor mutational burden [TMB]) will be randomized to receive pembrolizumab in combination with …

CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0310)
 (2.8 away) Contact site
  • 352 views
  • 02 Aug, 2021
  • +92 other locations
Zimura Compared to Sham in Patients With Autosomal Recessive Stargardt Disease (STGD1)

To evaluate the safety and efficacy of Zimura (complement factor C5 inhibitor) compared to Sham in subjects with autosomal recessive Stargardt disease 1 (STGD1).

Montreal Children's Hospital
 (2.4 away) Contact site
  • 114 views
  • 24 Jul, 2021
  • +40 other locations
A Safety Efficacy And Pharmacokinetics Study Of Tofacitinib In Pediatric Patients With sJIA

A randomized withdrawal study in which responders to open-label treatment with tofacitinib will be randomized in a 1:1 ratio to tofacitinib or placebo in a double-blind phase. In the double-blind phase "time to sJIA flare" will be evaluated as primary endpoint and subjects will be discontinued once they experience sJIA …

McGill University Health Center, Glen Site
 (2.4 away) Contact site
  • 134 views
  • 02 Aug, 2021
  • +100 other locations
A Study of BR Alone Versus in Combination With Acalabrutinib in Subjects With Previously Untreated MCL

This study is evaluating the efficacy of acalabrutinib in combination with bendamustine and rituximab (BR) compared with placebo plus BR in subjects with previously untreated mantle cell lymphoma.

cyclin d1
bendamustine
acalabrutinib
rituximab
Research Site
 (3.9 away) Contact site
  • 1270 views
  • 24 Jul, 2021
  • +250 other locations
Cisplatin + Radiotherapy vs Durvalumab + Radiotherapy Followed by Durvalumab vs Durvalumab + Radiotherapy Followed by Tremelimumab + Durvalumab in Intermediate-Risk HPV-Positive Oropharyngeal SCC

Sometimes, cancer patients receive an initial treatment, followed by additional treatment to lower the chance of cancer coming back. The standard or usual treatment for this type of disease is initially having radiation therapy at the same time as chemotherapy (with a drug called cisplatin), with no additional therapy afterwards

cancer
oropharyngeal carcinoma
pet/ct scan
human papillomavirus
neutrophil count
The Research Institute of the McGill University
 (2.4 away) Contact site
  • 56 views
  • 24 Jul, 2021
  • +29 other locations
ADCC Mediated B-Cell dEpletion and BAFF-R Blockade

VAY736 dose testing; VAY736 efficacy and safety testing.

adcc
Novartis Investigative Site
 (0.8 away) Contact site
  • 83 views
  • 25 Jul, 2021
  • +59 other locations
Efficacy and Safety of Tezepelumab in Participants With Severe Chronic Rhinosinusitis With Nasal Polyposis

A Multicentre, Randomised, Double-Blind, Parallel-Group, Placebo-Controlled Phase 3 Efficacy and Safety Study of Tezepelumab in Participants with Severe Chronic Rhinosinusitis with Nasal Polyposis

Research site
 (0.9 away) Contact site
  • 0 views
  • 24 Jul, 2021
  • +116 other locations
Effect of Sodium Zirconium Cyclosilicate on Arrythmia-related Cardiovascular Outcomes in Participants on Chronic Hemodialysis With Recurrent Hyperkalemia (DIALIZE-Outcomes)

The purpose of this study is to evaluate the effect of Sodium Zirconium Cyclosilicate (SZC) on arrhythmia-related cardiovascular outcomes in participants on chronic hemodialysis with recurrent hyperkalemia.

Research site
 (0.9 away) Contact site
  • 0 views
  • 02 Aug, 2021
  • +252 other locations
A Study of ASP1948 Targeting an Immune Modulatory Receptor as a Single Agent and in Combination With a PD-l Inhibitor (Nivolumab or Pembrolizumab) in Subjects With Advanced Solid Tumors

The purpose of this study is to evaluate the tolerability and safety profile of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab in participants with locally advanced (unresectable) or metastatic solid tumors; characterize the pharmacokinetic profile of ASP1948 when administered as a single agent …

Dartmouth Hitchcock Med Center
 (140.8 away) Contact site
  • 122 views
  • 04 Aug, 2021
  • +59 other locations