Moncton, Canada Clinical Trials

A listing of Moncton, Canada clinical trials actively recruiting patients volunteers.

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Found 44 clinical trials
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A Phase 2, Open-Label, Randomized, Multicenter Study to Evaluate the Efficacy and Safety of Pemigatinib Plus Pembrolizumab Versus Pemigatinib Alone Versus Standard of Care as First-Line Treatment for Metastatic or Unresectable Urothelial Carcinoma in Cisplatin-Ineligible Participants Whose Tumors Express FGFR3 Mutation or Rearrangement

The purpose of this study is to evaluate the safety and efficacy of pemigatinib plus pembrolizumab or pemigatinib alone versus the standard of care for participants with metastatic or unresectable urothelial carcinoma who are not eligible to receive cisplatin, are harboring FGFR3 mutation or rearrangement, and who have not received …

bladder carcinoma
urothelial carcinoma
metastatic urothelial carcinoma
bladder cancer
Moncton Hospital- Horizon Health Network
 (1.5 away) Contact site
  • 28 views
  • 14 Dec, 2020
  • +63 other locations
featured
Fox Insight - Online Parkinson's Health and Genetic Study

Fox Insight is an online study gathering health information from tens of thousands of people with and without Parkinson’s disease.  Study participation does not require any travel and all you need is an internet connection to start today at www.foxinsight.org Fox Insight volunteers are invited to take part in virtual …

www.foxinsight.org
 (2.6 away) Contact site
  • 3560 views
  • 29 Mar, 2021
  • +333 other locations
featured
A Randomized Phase 3 Study of Sitravatinib in Combination with Nivolumab Versus Docetaxel in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer with Disease Progression On or After Platinum-Based Chemotherapy and Checkpoint Inhibitor Therapy (SAPPHIRE)

This is an open-label, randomized (1:1), multicenter, Phase 3 clinical trial evaluating the safety and efficacy of nivolumab in combination with investigational agent sitravatinib compared to docetaxel in patients with advanced non-squamous NSCLC who have previously experienced radiographic disease progression on or after treatment with platinum-based chemotherapy in combination with …

advanced lung cancer
nivolumab
platinum-based chemotherapy
cancer chemotherapy
squamous non-small cell lung cancer
Horizon Health Network - The Moncton Hospital
 (1.7 away) Contact site
  • 213 views
  • 28 Jul, 2021
  • +188 other locations
A Study of Rucaparib Versus Physician's Choice of Therapy in Patients With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency

The purpose of this study is to determine how patients with metastatic castration-resistant prostate cancer, and evidence of a homologous recombination gene deficiency, respond to treatment with rucaparib versus treatment with physician's choice of abiraterone acetate, enzalutamide, or docetaxel.

Centre Hospitalier Universitaire Dr-Georges-L.-Dumont
 (0.7 away) Contact site
  • 2496 views
  • 24 Jul, 2021
  • +209 other locations
Efficacy and Safety of Olaparib Olaparib + Bevacizumab Compared to Bevacizumab + 5-Fluorouracil (FU)

This is an efficacy and safety study of olaparib alone or in combination with bevacizumab being compared to bevacizumab with Fluorouracil (5-FU) in participants with unresectable or metastatic colorectal cancer (CRC) who have not progressed following first-line induction of FOLFOX with bevacizumab. Hypothesis 1 - Olaparib + Bevacizumab is superior …

chemotherapy regimen
adenocarcinoma
colorectal adenocarcinoma
fluorouracil
oxaliplatin
Moncton Hospital - Horizon Health Network ( Site 0201)
 (1.8 away) Contact site
  • 10 views
  • 04 Aug, 2021
  • +122 other locations
Study of Evobrutinib in Participants With RMS (evolutionRMS 1)

The study is to evaluate the efficacy and safety of evobrutinib administered orally twice daily versus Teriflunomide (Aubagio), administered orally once daily in participants with Relapsing Multiple Sclerosis (RMS).

evobrutinib
aubagio
teriflunomide
Research Site 128
 (0.4 away) Contact site
  • 0 views
  • 30 Jul, 2021
  • +270 other locations
Brief Title: Study of Efficacy and Safety of Canakinumab as Adjuvant Therapy in Adult Subjects With Stages AJCC/UICC v. 8 II-IIIA and IIIB (T>5cm N2) Completely Resected Non-small Cell Lung Cancer Acronym: CANOPY-A

The primary purpose of the study is to compare the efficacy and safety of canakinumab versus placebo as adjuvant therapy in adult subjects with stages AJCC/UICC v. 8 II -IIIA and the subset of IIIB (T>5cm N2 disease) completely resected (R0) non-small cell lung cancer (NSCLC).

alopecia
lung carcinoma
systemic therapy
Novartis Investigative Site
 (1.8 away) Contact site
  • 645 views
  • 15 Jul, 2021
  • +414 other locations
Pomalidomide in Combination With Low-dose Dexamethasone or Pomalidomide in Combination With Low-dose Dexamethasone and Daratumumab in Subjects With Relapsed or Refractory Multiple Myeloma Following Lenalidomide-based Therapy in the First or Second Line Setting

This trial will evaluate the efficacy and safety of combination of pomalidomide (POM) and low-dose dexamethasone (LD-Dex) (Cohort A) or the combination of pomalidomide (POM) , daratumumab (DARA) and low-dose dexamethasone (LD-Dex) (Cohort B) in subjects with relapsed or refractory multiple myeloma who have received a first or second line …

dexamethasone
measurable disease
bone marrow procedure
lenalidomide
pomalidomide
Vitalite Health Network
 (0.7 away) Contact site
  • 79 views
  • 24 Jan, 2021
  • +47 other locations
Randomized Placebo-controlled Trial of FCM as Treatment for Heart Failure With Iron Deficiency

The primary objective of this study is to determine the efficacy and safety of iron therapy using intravenous (IV) ferric carboxymaltose (FCM), relative to placebo in the treatment of participants in heart failure with a reduced ejection fraction and with iron deficiency

natriuretic peptide
nt-probnp
ejection fraction
bypass graft
nesiritide
Nova Scotia Health Authority
 (114.8 away) Contact site
  • 5316 views
  • 02 Aug, 2021
  • +365 other locations
GEN3013 Trial in Patients With Relapsed Progressive or Refractory B-Cell Lymphoma

The trial is an open-label, multi-center safety trial of epcoritamab GEN3013 (DuoBody-CD3xCD20). The trial consists of two parts: a dose escalation part phase 1, first-in-human (FIH) and an expansion part phase 2a.

ct scan
renal function tests
measurable disease
renal function
diffuse large b-cell lymphoma
Rhode Island Hospital
 (440.6 away) Contact site
  • 316 views
  • 04 Aug, 2021
  • +99 other locations