Markham, Canada Clinical Trials

A listing of Markham, Canada clinical trials actively recruiting patients volunteers.

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Found 384 clinical trials
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Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy

The purpose of this study is to determine whether FT218 is safe and effective for the treatment of excessive daytime sleepiness and cataplexy in subjects with narcolepsy.

multiple sleep latency test
excessive daytime sleepiness
somnolence
sleep disorder
stimulant
Somni Research Inc
 (2.8 away) Contact site
  • 0 views
  • 10 Jul, 2018
  • +52 other locations
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A Phase 2, Randomized, Dose-Ranging, Vehicle-Controlled and Triamcinolone 0.1% Cream–Controlled Study to Evaluate the Safety and Efficacy of INCB018424 Phosphate Cream Applied Topically to Adults With Atopic Dermatitis

A Phase 2, Randomized, Dose-Ranging, Vehicle-Controlled and Triamcinolone 0.1% Cream–Controlled Study to Evaluate the Safety and Efficacy of INCB018424 Phosphate Cream Applied Topically to Adults With Atopic Dermatitis

dermatitis
atopic dermatitis/eczema
atopic dermatitis
LYNDERM RESEARCH INC
 (5.2 away) Contact site
  • 1344 views
  • 08 Dec, 2020
  • +52 other locations
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INCB 18424-303: Topical Ruxolitinib Evaluation in Atopic Dermatitis Study 1 (TRuE-AD1)

A Phase 3, randomized (2:2:1), double-blind, 8-week vehicle control efficacy and safety study of ruxolitinib followed by a randomized, double-blind, 44-week long term safety (LTS) extension period.  In the LTS period,  participants initially randomized to vehicle will receive either ruxolitinib 0.75% or 1.5% cream.  All participants will have follow-up assessments …

atopic dermatitis
atopic dermatitis/eczema
eczema
LYNDERM RESEARCH INC
 (4.0 away) Contact site
  • 242 views
  • 14 Dec, 2020
  • +37 other locations
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We are currently recruiting patients with Palmoplantar Pustulosis (PPP). This study investigates the Efficacy and safety of ANB019.

The study drug consists of a sub-cutaneous investigational treatment or a placebo, that will be administered on Day 1, followed by 3 doses of the study treatment on Days 29, Day 57 and Day 85. Several blood samples will be collected throughout the study. Your participation in the biopsy portion …

skin disorder
skin disease
psoriasis
Lynderm Research Inc.
 (4.0 away) Contact site
  • 28 views
  • 22 Dec, 2020
  • +23 other locations
Study of Quavonlimab (MK-1308) in Combination With Pembrolizumab (MK-3475) in Advanced Solid Tumors (MK-1308-001)

This study will assess the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of escalating doses of quavonlimab when used in combination with pembrolizumab in participants with advanced solid tumors.

Sunnybrook Research Institute ( Site 1103)
 (9.5 away) Contact site
  • 742 views
  • 26 Jun, 2021
  • +52 other locations
A Study of BR Alone Versus in Combination With Acalabrutinib in Subjects With Previously Untreated MCL

This study is evaluating the efficacy of acalabrutinib in combination with bendamustine and rituximab (BR) compared with placebo plus BR in subjects with previously untreated mantle cell lymphoma.

acalabrutinib
cyclin d1
rituximab
bendamustine
Research Site
 (9.5 away) Contact site
  • 1270 views
  • 24 Jul, 2021
  • +250 other locations
A Study of Rucaparib Versus Physician's Choice of Therapy in Patients With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency

The purpose of this study is to determine how patients with metastatic castration-resistant prostate cancer, and evidence of a homologous recombination gene deficiency, respond to treatment with rucaparib versus treatment with physician's choice of abiraterone acetate, enzalutamide, or docetaxel.

Sunnybrook Odette Cancer Centre
 (9.5 away) Contact site
  • 2496 views
  • 24 Jul, 2021
  • +209 other locations
A Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer

A phase III multi-center, randomized, open-label trial to evaluate efficacy and safety of ribociclib with endocrine therapy as adjuvant treatment in patients with HR+/HER2- Early Breast Cancer

Novartis Investigative Site
 (9.5 away) Contact site
  • 211 views
  • 17 Jul, 2021
  • +362 other locations
Durvalumab vs Placebo With Stereotactic Body Radiation Therapy in Early Stage Unresected Non-small Cell Lung Cancer Patients

This is a Phase III, randomized, placebo-controlled, double-blind, multi-center study assessing the efficacy and safety of durvalumab with SoC SBRT versus placebo with SoC SBRT in patients with unresected clinical Stage I/II lymph node-negative (T1 to T3N0M0) NSCLC.

lung carcinoma
stereotactic body radiation therapy
durvalumab
Research Site
 (9.5 away) Contact site
  • 68 views
  • 28 Apr, 2021
  • +226 other locations
Study on Olaparib Plus Abiraterone as First-line Therapy in Men With Metastatic Castration-resistant Prostate Cancer

The purpose of this study is to evaluate the efficacy and safety (including evaluating side effects) of combination of olaparib and abiraterone versus placebo and abiraterone in patients with metastatic castration-resistant prostate cancer (mCRPC) who have received no prior cytotoxic chemotherapy or new hormonal agents (NHAs) at metastatic castration-resistant prostate …

MRI
ct scan
gonadotropin releasing hormone
abiraterone
prostate adenocarcinoma
Research Site
 (9.5 away) Contact site
  • 200 views
  • 23 Jul, 2021
  • +194 other locations