London, Canada Clinical Trials

A listing of London, Canada clinical trials actively recruiting patients volunteers.

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Found 42 clinical trials
Featured trial
Caregiver-Provided Life Review for Persons with Dementia

This study, Caregiver-Provided Life Review (C-PLR) is created based on Life Review therapy. It is for persons living with early-stage dementia along with mild depressive symptoms who are 65 years or older, community-dwellers or the residents of senior housing, independent or assisted living facilities conducted by their family members (18 …

dementia
Accepts healthy volunteers
depression
Online studies
Online Study Center
(online study) Contact site
  • 566 views
  • 09 Aug, 2022
  • 1 location
  • Online study
Enfortumab Vedotin and Pembrolizumab vs. Chemotherapy Alone in Untreated Locally Advanced or Metastatic Urothelial Cancer (EV-302)

This study is being done to see how well two drugs (enfortumab vedotin and pembrolizumab) work together to treat patients with urothelial cancer. The study will compare these drugs to other drugs that are usually used to treat this cancer (standard of care). The patients in this study will have …

carboplatin
enfortumab vedotin
measurable disease
gemcitabine
transitional cell carcinoma
Site CA11009
 (0.3 away) Contact site
  • 121 views
  • 11 Aug, 2022
  • +190 other locations
RESPONSE: Response to Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and an Inadequate Control to or an Intolerance to Ursodeoxycholic Acid (UDCA)

To evaluate the treatment effect of seladelpar on composite biochemical improvement in cholestasis markers based on ALP and total bilirubin and to evaluate the safety of seladelpar over 12 months of treatment compared to placebo

London Health Sciences Centre
 (0.3 away) Contact site
  • 5 views
  • 08 Aug, 2022
  • +157 other locations
Safety, Tolerability, and Efficacy of AXA1125 in NASH With Fibrosis

This study will compare the effects of AXA1125, an orally active mixture of amino acids, compared to placebo, on improving fat and inflammation (steatohepatitis) as well as fibrosis in subjects with non alcoholic steatohepatitis (NASH). as well as the safety and tolerability of AXA1125. Subjects will take one of two …

Toronto Liver Centre
 (102.0 away) Contact site
  • 0 views
  • 09 Aug, 2022
  • +72 other locations
A Study to Test Safety and Efficacy of BI456906 in Adults With Non-alcoholic Steatohepatitis (NASH) and Fibrosis (F1-F3)

This study is open for men and women with a liver disease called nonalcoholic steatohepatitis (NASH) and liver fibrosis. The purpose of the study is to find out whether a medicine called BI 456906 helps patients with NASH and liver fibrosis. The study tests 3 different doses of BI 456906 …

University Hospital (LHSC)
 (0.3 away) Contact site
  • 71 views
  • 09 Aug, 2022
  • +170 other locations
A Study of Fezolinetant to Treat Hot Flashes in Women Going Through Menopause (Daylight)

This study is for women in menopause who have moderate to severe hot flashes. It is for women who are unable to use hormone replacement therapy (HRT). Menopause, a normal part of life, is the time after a woman's last period. Hot flashes often occur during menopause. They can disrupt …

Site CA15010
 (3.1 away) Contact site
  • 25 views
  • 11 Aug, 2022
  • +89 other locations
A Study of JNJ-77242113 for the Treatment of Moderate-to-Severe Plaque Psoriasis (SUMMIT)

The purpose of the study is to evaluate the efficacy of an oral tablet formulation of JNJ-77242113 compared with placebo in participants with moderate-to-severe plaque psoriasis.

The Guenther Dermatology Research Centre
 (1.4 away) Contact site
  • 0 views
  • 11 Aug, 2022
  • +19 other locations
A Study of the Safety and Tolerability of GTX-102 in Children With Angelman Syndrome (KIK-AS)

The primary objective of the study is to evaluate the safety and tolerability of multiple-ascending doses of GTX-102 administered by IT injection to patients with AS.

Children's Hospital of Western Ontario
 (2.1 away) Contact site
  • 198 views
  • 09 Aug, 2022
  • +6 other locations
A Study to Assess Adverse Events and Disease Activity With Cedirogant (ABBV-157) in Adult Participants With Moderate to Severe Psoriasis

Psoriasis is a chronic disease characterized by marked inflammation and thickening of the skin that results in thick, scaly skin plaques. This study will assess how safe and effective cedirogant (ABBV-157) is compared to placebo in adult participants with moderate to severe psoriasis. Efficacy and safety-related measurements are assessing disease …

plaque psoriasis
phototherapy
desquamation
systemic therapy
Dr. Wei Jing Loo Medicine Prof /ID# 238865
 (4.8 away) Contact site
  • 4 views
  • 10 Aug, 2022
  • +51 other locations
Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipation (FC)

The objective of LIN-MD-64 is to evaluate the safety and efficacy of 12 weeks of linaclotide therapy (72 μg daily) in comparison with placebo in pediatric participants, 6 to 17 years of age, who fulfill modified Rome III Criteria for Child/Adolescent Functional Constipation (FC). The objective of LIN-MD-64 is to …

incontinence
posturing
laxative
London Health Sciences Center /ID# 233068
 (0.3 away) Contact site
  • 136 views
  • 11 Aug, 2022
  • +80 other locations