Kirkland, Canada Clinical Trials

A listing of Kirkland, Canada clinical trials actively recruiting patients volunteers.

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Found 26 clinical trials
Study of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (MK-3475-365/KEYNOTE-365)

The purpose of this study is to assess the safety and efficacy of pembrolizumab (MK-3475) combination therapy in patients with metastatic castrate resistant prostate cancer (mCRPC). There will be nine cohorts in this study: Cohort A will receive pembrolizumab + olaparib, Cohort B will receive pembrolizumab + docetaxel + prednisone, …

bone scan
gonadotropin releasing hormone
solid tumour
bone metastases
dexamethasone 8 mg
Merck Canada
 (0.7 away) Contact site
  • 0 views
  • 25 Jul, 2021
  • +13 other locations
Antimicrobial Prophylaxis for Skin Colonization With Propionibacterium Acnes in Primary Open Shoulder Surgery

INESS Antibiotic Prophylaxis in Orthopedic Guide recommends the use of Cefazolin at induction for all orthopaedic procedure with implantation of internal fixation device. With the increasing rate of identified P. acnes shoulder surgery infection despite the use of recommended skin preparation and preoperative prophylactic antibiotics, a question arises; Is Cefazolin …

H pital du Sacr -C ur de Montr al
 (8.9 away) Contact site
  • 142 views
  • 20 Jul, 2021
  • +1 other locations
Safety and Efficacy of Pembrolizumab (MK-3475) Plus Binimetinib Alone or Pembrolizumab Plus Chemotherapy With or Without Binimetinib in Metastatic Colorectal Cancer (mCRC) Participants (MK-3475-651)

The purpose of this study is to determine safety and tolerability and to establish a preliminary recommended Phase 2 dose (RP2D) for the following combinations: pembrolizumab plus binimetinib (Cohort A), pembrolizumab plus mFOLFOX7 (oxaliplatin 85 mg/m^2; leucovorin [calcium folinate] 400 mg/m^2; fluorouracil [5-FU] 2400 mg/m^2) (Cohort B), pembrolizumab plus mFOLFOX7 …

measurable disease
combinations
fluoropyrimidine
systemic chemotherapy
oxaliplatin
Jewish General Hospital ( Site 0121)
 (0.7 away) Contact site
  • 60 views
  • 25 Jul, 2021
  • +13 other locations
A Study of Neoadjuvant/Adjuvant Durvalumab for the Treatment of Patients With Resectable Non-small Cell Lung Cancer

This is a Phase III, randomized, double-blind, placebo-controlled, multi-center international study assessing the activity of durvalumab and chemotherapy administered prior to surgery compared with placebo and chemotherapy administered prior to surgery in terms of pathological complete response.

durvalumab
gemcitabine
carboplatin
carboplatin/paclitaxel
pemetrexed
Research Site
 (8.9 away) Contact site
  • 251 views
  • 25 Jul, 2021
  • +311 other locations
Study to Evaluate the Efficacy Safety and Tolerability of Vibegron in Men With Overactive Bladder (OAB) Symptoms on Pharmacological Therapy for Benign Prostatic Hyperplasia (BPH)

This study will assess the efficacy of vibegron compared with placebo in men with overactive bladder (OAB) symptoms on pharmacological therapy for benign prostatic hyperplasia (BPH) as defined by micturition and urgency episodes.

micturition chart
cancer
vibegron
benign prostatic hypertrophy
nocturia
Private Practice
 (1.5 away) Contact site
  • 959 views
  • 15 Jul, 2021
  • +170 other locations
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes

This study will look at the long-term effects of semaglutide (active medicine) on diabetic eye disease when compared to placebo (dummy medicine). The study will be performed in people with type 2 diabetes. Participants will either get semaglutide or placebo in addition to their diabetes medicines - which treatment the …

semaglutide
hypoglycemic agents
Novo Nordisk Investigational Site
 (8.8 away) Contact site
  • 581 views
  • 25 Jul, 2021
  • +237 other locations
Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)

During end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested. This trial will evaluate whether compared to high levels, lowering blood phosphate levels would reduce death or major events due …

renal failure
dialysis
heart disease
diabetes
nephropathy
Sacre Coeur Hospital
 (8.9 away) Contact site
  • 91 views
  • 15 Jul, 2021
  • +54 other locations
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

The primary objective of this study is to evaluate the effectiveness (prevention of thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC) to background antiplatelet therapy in patients who develop new-onset post-operative atrial fibrillation (POAF) after isolated coronary artery bypass graft (CABG) surgery. All patients with a qualifying …

clopidogrel
atrial fibrillation
aspirin
fibrillation
anticoagulation therapy
H pital du Sacr -C ur de Montr al
 (8.9 away) Contact site
  • 112 views
  • 22 Jul, 2021
  • +79 other locations
Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL

Participants in this study will have diffuse large B-cell lymphoma (DLBCL) that has come back or not gotten better with treatment. The trial will study whether brentuximab vedotin plus two drugs works better to treat this type of cancer than the two drugs alone. Patients will be randomly assigned to …

measurable disease
lenalidomide
avid
rituximab
b-cell lymphoma
CIUSS NIM/Hopital du Sacre-Coeur de Montreal
 (8.9 away) Contact site
  • 0 views
  • 25 Jul, 2021
  • +67 other locations
Intra-articular Vancomycin Powder in Knee and Hip Arthroplasty

The purpose of this study is to compare infection rates when patients, elected for primary or aseptic revision THA / TKA, have a single intravenous antibiotic dose versus one single intravenous antibiotic dose in combination with intra-articular antibiotics. This is a prospective, randomized clinical survey on selected outcome measurements on …

Hopital Sacr -Coeur de Montreal
 (8.9 away) Contact site
  • 0 views
  • 21 Jul, 2021
  • 1 location