Kingston, Canada Clinical Trials

A listing of Kingston, Canada clinical trials actively recruiting patients volunteers.

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Found 78 clinical trials
A Phase 3, Randomized, Open Label Study to Compare Nivolumab Plus Concurrent Chemoradiotherapy (CCRT) Followed by Nivolumab Plus Ipilimumab or Nivolumab Plus CCRT Followed by Nivolumab vs CCRT Followed by Durvalumab in Previously Untreated, Locally Advanced Non-small Cell Lung Cancer (LA NSCLC) (CheckMate73L)

The primary purpose of the study is to compare the effectiveness of nivolumab plus concurrent chemoradiotherapy (CCRT) followed by nivolumab plus ipilimumab vs CCRT followed by durvalumab in participants with untreated Locally Advanced Non-small Cell Lung Cancer (LA NSCLC).

nivolumab
lung carcinoma
chemoradiotherapy
durvalumab
Local Institution
 (0.6 away) Contact site
  • 28 views
  • 19 Sep, 2022
  • +166 other locations
EMPACT-MI: A Streamlined, Multicentre, Randomised, Parallel Group, Double-blind Placebo-controlled Superiority Trial to Evaluate the Effect of EMPAgliflozin on Hospitalisation for Heart Failure and Mortality in Patients With aCuTe Myocardial Infarction

This is a study in adults who had a heart attack (myocardial infarction). The purpose of this study is to find out whether a medicine called empagliflozin helps to lower the chances of having to go to the hospital for heart failure and whether it lowers the chances of dying …

acute myocardial infarction
atherosclerosis
heart failure
cardiovascular disease
stemi
Queen's University
 (0.5 away) Contact site
  • 204 views
  • 19 Sep, 2022
  • +437 other locations
A Multi-center, Randomized, Double-blind, Parallel-group, Placebo-controlled 3-Part Phase 3 Study to Demonstrate the Efficacy and Safety of Benralizumab in Patients With Eosinophilic Gastritis and/or Gastroenteritis (The HUDSON GI Study) (HUDSON GI)

This is a 3-part study. Part A and B have identical designs and are randomized, double-blinded, placebo-controlled studies, which will include patients with eosinophilic gastritis and/or duodenal-only disease. Part A will be enrolled first, followed by Part B. After completing Part A or Part B, participants will continue to Part …

Research Site
 (0.6 away) Contact site
  • 0 views
  • 19 Sep, 2022
  • +42 other locations
A Phase 3, Multicenter, Randomized, Double-Blind Study of MK-7684 With Pembrolizumab as a Coformulation (MK-7684A) Versus Pembrolizumab Monotherapy as First Line Treatment for Participants With PD-L1 Positive Metastatic Non-Small Cell Lung Cancer

The primary hypotheses are that coformulated pembrolizumab/vibostolimab is superior to pembrolizumab alone with respect to (1) overall survival (OS) in participants with programmed cell death 1 ligand 1 (PD-L1) tumor proportion score (TPS) ≥50%, TPS ≥1% and TPS 1% to 49%; and (2) progression-free survival (PFS) per Response Evaluation Criteria …

epidermal growth factor
lung cancer
growth factor
ROS1
proto-oncogene tyrosine-protein kinase ros
Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 0102)
 (0.6 away) Contact site
  • 8 views
  • 22 Sep, 2022
  • +126 other locations
SyncAV Post-Market Trial (SyncAV)

The SyncAV Post-Market Trial is a prospective, randomized, multi-center trial performed to determine if cardiac resynchronization therapy (CRT) devices programmed with SyncAV ON improve long-term CRT response compared to devices programmed with conventional CRT through evaluation of changes in left ventricular (LV) reverse remodeling.

cardiac resynchronization therapy
left bundle branch block
heart failure
beta blockers
aldosterone
Kingston General Hospital
 (0.7 away) Contact site
  • 0 views
  • 20 Sep, 2022
  • +100 other locations
A Randomized, Double-Blind, Placebo- Controlled Trial of Adjunctive Troriluzole in Obsessive Compulsive Disorder

The study's purpose its to evaluate the efficacy and safety of troriluzole as adjunctive therapy compared to placebo in subjects with Obsessive Compulsive Disorder (OCD)

serotonin reuptake inhibitors
fluvoxamine
clomipramine
Queen's University
 (0.5 away) Contact site
  • 200 views
  • 20 Sep, 2022
  • +76 other locations
Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR): A Phase II Basket Trial (CAPTUR)

Cancer drugs which target the effects of abnormal gene changes are called 'targeted therapies'. This study, called PM.1 or CAPTUR, will include some targeted therapies that are currently available. The purpose of this study is to find out what are the effects on a patient and their cancer when they …

solid tumour
multiple myeloma
neutrophil count
nivolumab
cancer
Kingston Health Sciences Centre
 (0.6 away) Contact site
  • 63 views
  • 21 Sep, 2022
  • +8 other locations
A Phase 3, Randomized, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Stereotactic Body Radiotherapy (SBRT) With or Without Pembrolizumab (MK-3475) in Participants With Unresected Stages I or II Non Small Cell Lung Cancer (NSCLC) (KEYNOTE-867)

The purpose of this study is to assess the efficacy and safety of stereotactic body radiotherapy (SBRT) plus pembrolizumab (MK-3475) in the treatment of adult participants with unresected stage I or II (Stage IIB N0, M0) non-small cell lung cancer (NSCLC). The primary study hypotheses are: SBRT plus pembrolizumab prolongs …

pembrolizumab
stereotactic body radiation therapy
lung carcinoma
mk-3475
Kingston Health Sciences Centre ( Site 0100)
 (0.6 away) Contact site
  • 121 views
  • 21 Sep, 2022
  • +136 other locations
A Phase 3 Trial Investigating Blinatumomab (NSC# 765986) in Combination With Chemotherapy in Patients With Newly Diagnosed Standard Risk or Down Syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients With Localized B-Lymphoblastic Lymphoma (B-LLy)

This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. Monoclonal antibodies, such as blinatumomab, may induce changes in the body's immune system and may interfere with the ability …

monoclonal antibody therapy
prednisone
pegaspargase
cancer
flow cytometry
Kingston Health Sciences Centre
 (0.6 away) Contact site
  • 92 views
  • 21 Sep, 2022
  • +119 other locations
A Phase 3, Randomized, Double-Blind Study of Pembrolizumab Versus Placebo in Combination With Paclitaxel With or Without Bevacizumab for the Treatment of Platinum-resistant Recurrent Ovarian Cancer (KEYNOTE-B96/ENGOT-ov65)

The primary objective is to compare pembrolizumab plus paclitaxel with or without bevacizumab to placebo plus paclitaxel with or without bevacizumab, with respect to progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 as assessed by the investigator. The hypotheses are that pembrolizumab plus paclitaxel with or …

line of therapy
docetaxel
cancer chemotherapy
hormone therapy
bevacizumab
Kingston Health Sciences Centre-Kingston General Hospital Si-Oncology and/or Hematology - Gynecolog
 (0.6 away) Contact site
  • 1 views
  • 19 Sep, 2022
  • +141 other locations