Hamilton, Canada Clinical Trials

A listing of Hamilton, Canada clinical trials actively recruiting patients volunteers.

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Found 432 clinical trials
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Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis

www.MyelofibrosisResearch.com Myelofibrosis (MF) is a bone marrow illness that affects blood-forming tissues in the body. MF disturbs the body's normal production of blood cells, causing extensive scarring in the bone marrow. This leads to severe anemia, weakness, fatigue, and an enlarged spleen. The purpose of this study is to assess …

Juravinski Hosp & Cancer Cntr /ID# 220887
 (1.7 away) Contact site
  • 164 views
  • 29 Apr, 2021
  • +224 other locations
featured
Study of Oral Navitoclax Tablet In Combination With Oral Ruxolitinib Tablet When Compared With Oral Ruxolitinib Tablet To Assess Change In Spleen Volume In Adult Participants With Myelofibrosis

www.MyelofibrosisResearch.com Myelofibrosis is a type of bone marrow cancer that usually develops slowly and disrupts body's normal production of blood cells. It causes bone marrow scarring, leading to severe anemia that can cause weakness and fatigue. It can also cause a low number of blood-clotting cells called platelets, which increases …

Juravinski Cancer Clinic /ID# 221752
 (1.7 away) Contact site
  • 32 views
  • 29 Apr, 2021
  • +148 other locations
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A Randomized Phase 3 Study of Sitravatinib in Combination with Nivolumab Versus Docetaxel in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer with Disease Progression On or After Platinum-Based Chemotherapy and Checkpoint Inhibitor Therapy (SAPPHIRE)

This is an open-label, randomized (1:1), multicenter, Phase 3 clinical trial evaluating the safety and efficacy of nivolumab in combination with investigational agent sitravatinib compared to docetaxel in patients with advanced non-squamous NSCLC who have previously experienced radiographic disease progression on or after treatment with platinum-based chemotherapy in combination with …

squamous non-small cell lung cancer
lung carcinoma
experimental drug
cancer
platinum-based chemotherapy
Juravinski Cancer Centre
 (1.6 away) Contact site
  • 199 views
  • 28 Jun, 2021
  • +182 other locations
Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease

Individuals receiving dialysis are at risk of heart failure and heart related death. There is an urgent need for treatments that reduce the risk of these problems in patients that require dialysis. Spironolactone is a pill used to prevent heart failure and related deaths in patients that do not require …

St. Joseph's Healthcare
 (0.5 away) Contact site
  • 41 views
  • 26 Jan, 2021
  • +97 other locations
A Study of the Effects of ALKS 4230 (Nemvaleukin Alfa) on Subjects With Solid Tumors

To better understand the safety and tolerability of ALKS 4230 in humans

Alkermes Investigational Site
 (36.6 away) Contact site
  • 0 views
  • 02 May, 2021
  • +25 other locations
Vinblastine +/- Bevacizumab in Children With Unresectable or Progressive Low Grade Glioma (LGG)

This is an open-label, randomized, multi-center, comparator Phase II trial looking at the addition of Bevacizumab to Vinblastine in chemotherapy nave pediatric patients with progressive Low Grade Glioma aged 6 months to less than18 years of age at the time of initiation of therapy. Participants will be randomized to Arm …

auditory test
glomerular filtration rate
platelet count
neutrophil count
BRAF
The Hospital for Sick Children
 (36.7 away) Contact site
  • 0 views
  • 24 Jan, 2021
  • +23 other locations
Phase ll Study of Pirfenidone in Patients With RAILD (TRAIL1)

The purpose of this study is to to assess the safety and tolerability of pirfenidone 2403 mg/day for the treatment of RA-associated interstitial lung disease.

St. Joseph's Healthcare
 (0.5 away) Contact site
  • 207 views
  • 23 Jan, 2021
  • +30 other locations
A Phase 3 Multi-Center Randomized Double-Blind Placebo-Controlled Study of Fostamatinib Disodium in the Treatment of wAIHA

The primary objective of this study is to assess the efficacy of fostamatinib in subjects with warm antibody autoimmune hemolytic anemia (wAIHA).

Hamilton Health Sciences- McMaster University Medical Centre
 (2.4 away) Contact site
  • 113 views
  • 25 Jul, 2021
  • +124 other locations
Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC

A Global Study to Determine the Efficacy and Safety of Durvalumab in Combination with Gemcitabine+Cisplatin for Neoadjuvant Treatment and Durvalumab Alone for Adjuvant Treatment in Patients with Muscle-Invasive Bladder Cancer

Research Site
 (1.6 away) Contact site
  • 147 views
  • 14 Jul, 2021
  • +264 other locations
Pembrolizumab Versus Placebo Following Surgery and Radiation in Participants With Locally Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630/KEYNOTE-630)

This is a randomized, double-blind, study that compares pembrolizumab with placebo given as adjuvant therapy in participants with high-risk locally advanced cutaneous squamous cell carcinoma (LA cSCC) that have undergone surgery with curative intent in combination with radiotherapy. The primary hypothesis is that pembrolizumab is superior to placebo in increasing …

adjuvant therapy
pembrolizumab
cancer
mk-3475
Juravinski Cancer Center ( Site 0151)
 (1.6 away) Contact site
  • 69 views
  • 22 Jul, 2021
  • +146 other locations