East York, Canada Clinical Trials

A listing of East York, Canada clinical trials actively recruiting patients volunteers.

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Found 11 clinical trials
Topotecan Episcleral Plaque for Treatment of Retinoblastoma

This single-arm, non-randomized, dose escalation phase I clinical trial will assess primarily the safety and secondarily the efficacy of episcleral topotecan in patients with active de novo or recurrent intraocular retinoblastoma in at least one eye following completion of first-line therapy.

renal function
intraocular retinoblastoma
neutrophil count
calcium
platelet count
Hospital for Sick Children
 (3.3 away) Contact site
  • 0 views
  • 18 Jul, 2021
  • 1 location
An Exploratory Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma and Non-Small Cell Lung Cancer With Liver Metastases (INTEGRATE)

This study is being done to look at how effective the drug, atezolizumab, with or without the drug bevacizumab, is for people with inoperable liver cancer or non-small lung cancer that has spread to the liver. This will be done by looking at the duration of time from starting the …

cancer
tyrosine
epidermal growth factor receptor
measurable disease
EGFR
Princess Margaret Cancer Centre
 (3.3 away) Contact site
  • 0 views
  • 16 Jul, 2021
  • 1 location
Physiotherapy and Deep Brain Stimulation in Parkinson's Disease

Deep brain stimulation (DBS) is the most commonly performed surgical treatment for individuals with Parkinson's disease (PD). DBS typically works best to lessen motor symptoms such as stiffness, slowness, and tremor. Despite an overall improvement of these motor symptoms with DBS, past research failed to show an increase in community …

motor symptoms
tremor
brain stimulation
Movement Disorders Centre - Toronto Western Hospital
 (4.1 away) Contact site
  • 0 views
  • 21 Jul, 2021
  • 1 location
Fabry Cardiomyopathy: Identification of Early Myocardial Structural and Tissue Abnormalities Using Multiparametric MRI

This study will evaluate whether cardiac MRI T1 and T2 mapping improves our ability to detect early abnormalities in the heart in patients with Fabry disease and identify patients at increase risk of adverse events.

cardiomyopathy
University Health Network
 (3.3 away) Contact site
  • 0 views
  • 21 Jul, 2021
  • 1 location
Emotion and Symptom-Focused Engagement Trial for Individuals With Acute Leukemia

The purpose of this study is to find out whether a novel manualized intervention, called Emotion and Symptom-focused Engagement (EASE), that combines psychological support with symptom screening plus triggered referral to early palliative care for symptom control, reduces psychological distress and physical symptom burden in individuals newly diagnosed with acute …

University Health Network
 (3.3 away) Contact site
  • 0 views
  • 20 Jul, 2021
  • +1 other locations
Feasibility of a Home Exercise Program to Manage Post-transplant Metabolic Syndrome

Post-transplant metabolic syndrome (PTMS) affects about 50% liver transplant (OLT) and 25% lung transplant (LTx) recipients at 12-18 months post-transplant. PTMS (comprised of glucose intolerance, obesity, hypercholesterolemia and hypertension) has been associated with increased risk for cardiovascular morbidity and long-term survival. Exercise studies in the early post-transplant period have shown …

insulin resistance
insulin
hypertension
diabetes
University Health Network - Toronto General Hospital
 (3.2 away) Contact site
  • 0 views
  • 21 Jul, 2021
  • 1 location
Stellate Ganglion Block for Major Depressive Disorder.

This is a feasibility study, to investigate a new treatment option for major depressive disorders by performing a Stellate Ganglion Block (SGB). A SGB is an injection of local anesthetic into the sympathetic nervous system (peripheral nervous system) located in the lower part of the neck, to relieve pain in …

St. Michael's Hospital
 (3.3 away) Contact site
  • 0 views
  • 22 Jul, 2021
  • 1 location
Effect of Gut Microbiome Restoration on Primary Hypertension Via FMT

Mounting preclinical and clinical evidences have proved the causal role of gut microbiota on the pathogenesis of primary hypertension. Restoration of gut microbiota ameliorated high BP in rodents and/or human cases.A hypothesis is thus raised that gut microbiome restoration can be a potential approach to ameliorate hypertension. This pilot study …

antihypertensive drugs
hypertension
systolic blood pressure
The People's Hospital of Ji Xian District
 (7.3 away) Contact site
  • 0 views
  • 22 Jul, 2021
  • +6 other locations
Development of Hardware and Software for Pulmonary Magnetic Resonance Imaging Using Inhaled Tracer Gases

This is a single centre study. The overarching hypothesis of this study is that MRI with inhaled tracer gases can provide high quality images of lung function to complement conventional 1H MRI. The study interventions do not affect the standard of care.

Hospital for Sick Children
 (3.3 away) Contact site
  • 0 views
  • 16 Jul, 2021
  • 1 location
Hyper-Personalized Medicine Using Patient Derived Xenografts (PDXovo) for Renal Cell Carcinoma Patients

The Investigators will use novel PDX (patient-derived xenograft) technology to form xenografts using material from metastatic renal cell carcinoma patients. Xenografts will be treated with a panel of drugs to determine which agent(s) yield the greatest anti-tumor effect on the xenograft.

carcinoma
cancer
nephrectomy
kidney cancer
metastatic cancer
Odette Cancer Centre
 (2.7 away) Contact site
  • 0 views
  • 09 Jul, 2021
  • 1 location