Downsview Ontario, Canada Clinical Trials

A listing of Downsview Ontario, Canada clinical trials actively recruiting patients volunteers.

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Found 13 clinical trials
Topotecan Episcleral Plaque for Treatment of Retinoblastoma

This single-arm, non-randomized, dose escalation phase I clinical trial will assess primarily the safety and secondarily the efficacy of episcleral topotecan in patients with active de novo or recurrent intraocular retinoblastoma in at least one eye following completion of first-line therapy.

neutrophil count
renal function
topotecan
platelet count
intraocular retinoblastoma
Hospital for Sick Children
 (7.4 away) Contact site
  • 0 views
  • 18 Jul, 2021
  • 1 location
ODYSSEE-vCHAT Pilot Trial for Chronic Heart Failure

INTRODUCTION Psychological distress[1,2] and reduced quality of life[2,3] are prevalent in patients with chronic heart failure (CHF). The one-year rehospitalization rate is very high (40%)[4], as well as the five-year mortality rates (45% for women and 60% for men)[5]. International task force committees report that medical therapy combined with digital …

Sunnybrook Health Sciences Centre
 (5.8 away) Contact site
  • 0 views
  • 25 Jul, 2021
  • +2 other locations
Physiotherapy and Deep Brain Stimulation in Parkinson's Disease

Deep brain stimulation (DBS) is the most commonly performed surgical treatment for individuals with Parkinson's disease (PD). DBS typically works best to lessen motor symptoms such as stiffness, slowness, and tremor. Despite an overall improvement of these motor symptoms with DBS, past research failed to show an increase in community …

motor symptoms
tremor
brain stimulation
Movement Disorders Centre - Toronto Western Hospital
 (7.0 away) Contact site
  • 0 views
  • 21 Jul, 2021
  • 1 location
Fabry Cardiomyopathy: Identification of Early Myocardial Structural and Tissue Abnormalities Using Multiparametric MRI

This study will evaluate whether cardiac MRI T1 and T2 mapping improves our ability to detect early abnormalities in the heart in patients with Fabry disease and identify patients at increase risk of adverse events.

cardiomyopathy
University Health Network
 (7.7 away) Contact site
  • 0 views
  • 24 Jul, 2021
  • 1 location
Emotion and Symptom-Focused Engagement Trial for Individuals With Acute Leukemia

The purpose of this study is to find out whether a novel manualized intervention, called Emotion and Symptom-focused Engagement (EASE), that combines psychological support with symptom screening plus triggered referral to early palliative care for symptom control, reduces psychological distress and physical symptom burden in individuals newly diagnosed with acute …

University Health Network
 (7.7 away) Contact site
  • 0 views
  • 20 Jul, 2021
  • +1 other locations
An Exploratory Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma and Non-Small Cell Lung Cancer With Liver Metastases (INTEGRATE)

This study is being done to look at how effective the drug, atezolizumab, with or without the drug bevacizumab, is for people with inoperable liver cancer or non-small lung cancer that has spread to the liver. This will be done by looking at the duration of time from starting the …

epidermal growth factor receptor
EGFR
tyrosine
measurable disease
cancer
Princess Margaret Cancer Centre
 (7.2 away) Contact site
  • 0 views
  • 16 Jul, 2021
  • 1 location
Feasibility of a Home Exercise Program to Manage Post-transplant Metabolic Syndrome

Post-transplant metabolic syndrome (PTMS) affects about 50% liver transplant (OLT) and 25% lung transplant (LTx) recipients at 12-18 months post-transplant. PTMS (comprised of glucose intolerance, obesity, hypercholesterolemia and hypertension) has been associated with increased risk for cardiovascular morbidity and long-term survival. Exercise studies in the early post-transplant period have shown …

diabetes
insulin resistance
hypertension
insulin
University Health Network - Toronto General Hospital
 (7.3 away) Contact site
  • 0 views
  • 21 Jul, 2021
  • 1 location
Stellate Ganglion Block for Major Depressive Disorder.

This is a feasibility study, to investigate a new treatment option for major depressive disorders by performing a Stellate Ganglion Block (SGB). A SGB is an injection of local anesthetic into the sympathetic nervous system (peripheral nervous system) located in the lower part of the neck, to relieve pain in …

St. Michael's Hospital
 (7.7 away) Contact site
  • 0 views
  • 22 Jul, 2021
  • 1 location
Virtual Reality Therapy to Improve Physical and Psychological Symptoms and Quality of Life for End-of-life Patients on a Palliative Care Unit

People with advanced and life-threatening illnesses experience challenges across multiple domains of function including physical, psychological, social, and spiritual. The benefits of non-pharmacological interventions for palliative care patients are well recognized, but are relatively under-utilized. Virtual Reality (VR) therapy may help address these challenges and be a valuable addition to …

anxiety
pain relieving
Baycrest Health Sciences
 (3.0 away) Contact site
  • 0 views
  • 25 Jul, 2021
  • 1 location
rTMS for Depression in Young Adults With Autism

The current clinical trial is focused on evaluating the efficacy of rTMS for treatment of depression in youth and young adults (hereafter called transition aged youth, TAY) with autism spectrum disorder (ASD). The motivation to undertake the current efficacy study is driven by: (1) the substantial impact of depression on …

Centre for Addiction and Mental Health
 (7.7 away) Contact site
  • 0 views
  • 26 Jul, 2021
  • 1 location