Dieppe, Canada Clinical Trials

A listing of Dieppe, Canada clinical trials actively recruiting patients volunteers.

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Found 20 clinical trials
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A Randomized Phase 3 Study of Sitravatinib in Combination with Nivolumab Versus Docetaxel in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer with Disease Progression On or After Platinum-Based Chemotherapy and Checkpoint Inhibitor Therapy (SAPPHIRE)

This is an open-label, randomized (1:1), multicenter, Phase 3 clinical trial evaluating the safety and efficacy of nivolumab in combination with investigational agent sitravatinib compared to docetaxel in patients with advanced non-squamous NSCLC who have previously experienced radiographic disease progression on or after treatment with platinum-based chemotherapy in combination with …

docetaxel
platinum-based chemotherapy
advanced lung cancer
nivolumab
lung carcinoma
Horizon Health Network - The Moncton Hospital
 (2.7 away) Contact site
  • 213 views
  • 28 Jul, 2021
  • +188 other locations
A Study of Rucaparib Versus Physician's Choice of Therapy in Patients With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency

The purpose of this study is to determine how patients with metastatic castration-resistant prostate cancer, and evidence of a homologous recombination gene deficiency, respond to treatment with rucaparib versus treatment with physician's choice of abiraterone acetate, enzalutamide, or docetaxel.

Centre Hospitalier Universitaire Dr-Georges-L.-Dumont
 (1.8 away) Contact site
  • 2496 views
  • 24 Jul, 2021
  • +209 other locations
Efficacy and Safety of Olaparib Olaparib + Bevacizumab Compared to Bevacizumab + 5-Fluorouracil (FU)

This is an efficacy and safety study of olaparib alone or in combination with bevacizumab being compared to bevacizumab with Fluorouracil (5-FU) in participants with unresectable or metastatic colorectal cancer (CRC) who have not progressed following first-line induction of FOLFOX with bevacizumab. Hypothesis 1 - Olaparib + Bevacizumab is superior …

colorectal adenocarcinoma
chemotherapy regimen
oxaliplatin
fluorouracil
adenocarcinoma
Moncton Hospital - Horizon Health Network ( Site 0201)
 (2.8 away) Contact site
  • 10 views
  • 04 Aug, 2021
  • +122 other locations
Study of Evobrutinib in Participants With RMS (evolutionRMS 1)

The study is to evaluate the efficacy and safety of evobrutinib administered orally twice daily versus Teriflunomide (Aubagio), administered orally once daily in participants with Relapsing Multiple Sclerosis (RMS).

aubagio
teriflunomide
evobrutinib
Research Site 128
 (1.9 away) Contact site
  • 0 views
  • 30 Jul, 2021
  • +270 other locations
Randomized Placebo-controlled Trial of FCM as Treatment for Heart Failure With Iron Deficiency

The primary objective of this study is to determine the efficacy and safety of iron therapy using intravenous (IV) ferric carboxymaltose (FCM), relative to placebo in the treatment of participants in heart failure with a reduced ejection fraction and with iron deficiency

bypass graft
natriuretic peptide
cardiac resynchronization therapy
heart failure
nesiritide
G.A. Research Associates, Ltd.
 (1.5 away) Contact site
  • 5316 views
  • 02 Aug, 2021
  • +365 other locations
GEN3013 Trial in Patients With Relapsed Progressive or Refractory B-Cell Lymphoma

The trial is an open-label, multi-center safety trial of epcoritamab GEN3013 (DuoBody-CD3xCD20). The trial consists of two parts: a dose escalation part phase 1, first-in-human (FIH) and an expansion part phase 2a.

rituximab
cell transplantation
stem cell transplantation
measurable disease
b-cell lymphoma
Regional Health Authority B
 (1.5 away) Contact site
  • 316 views
  • 04 Aug, 2021
  • +99 other locations
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calmette-Guerin (BCG) in High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) (MK-3475-676/KEYNOTE-676)

This study is designed to assess the antitumor efficacy and safety of pembrolizumab in combination with BCG, compared to BCG monotherapy, in participants with HR NMIBC that is either persistent or recurrent following adequate BCG induction (Cohort A), or that is nave to BCG treatment (Cohort B). The primary hypothesis …

Horizon Health Network ( Site 0160)
 (2.8 away) Contact site
  • 108 views
  • 04 Aug, 2021
  • +138 other locations
A Study to Test How Taking BI 1015550 for 12 Weeks Affects Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF)

This study is open to adults with idiopathic pulmonary fibrosis (IPF) who are at least 40 years old. People taking standard medicines for IPF, including antifibrotic medicines, can continue taking them throughout the study. The purpose of the study is to find out whether a medicine called BI 1015550 can …

idiopathic pulmonary fibrosis
ct scan
lung biopsy
pirfenidone
high resolution computed tomography
Dr. Georges-L.-Dumont University Hospital Centre
 (1.8 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +91 other locations
EMPACT-MI: A Study to Test Whether Empagliflozin Can Lower the Risk of Heart Failure and Death in People Who Had a Heart Attack (Myocardial Infarction)

This is a study in adults who had a heart attack (myocardial infarction). The purpose of this study is to find out whether a medicine called empagliflozin helps to lower the chances of having to go to the hospital for heart failure and whether it lowers the chances of dying …

revascularisation
angiography
heart failure
atherosclerosis
acute myocardial infarction
G.A. Research Associates Ltd
 (4.9 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +188 other locations
Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone on Morbidity (Events Indicating Disease Worsening) & Mortality (Death Rate) in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40%

The purpose of this study is to evaluate the effect of finerenone compared to placebo (a tablet without active substance) in the reduction of cardiovascular death (generally meaning death due to disease of the heart or blood vessels) and total Heart Failure (HF) events, including HF hospitalization and urgent visits …

b-type natriuretic peptide
natriuretic peptide
heart failure
ejection fraction
nt-probnp
G.A. Research Associates, Ltd.
 (1.5 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +778 other locations