Calgary, Canada Clinical Trials

A listing of Calgary, Canada clinical trials actively recruiting patients volunteers.

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Found 212 clinical trials
EMPACT-MI: A Streamlined, Multicentre, Randomised, Parallel Group, Double-blind Placebo-controlled Superiority Trial to Evaluate the Effect of EMPAgliflozin on Hospitalisation for Heart Failure and Mortality in Patients With aCuTe Myocardial Infarction

This is a study in adults who had a heart attack (myocardial infarction). The purpose of this study is to find out whether a medicine called empagliflozin helps to lower the chances of having to go to the hospital for heart failure and whether it lowers the chances of dying …

st elevation myocardial infarction
cardiovascular disease
stemi
angiography
acute myocardial infarction
Heritage Medical Research Clinic
 (3.0 away) Contact site
  • 204 views
  • 24 Oct, 2022
  • +436 other locations
A Phase II Trial of Tisagenlecleucel in First-line High-risk (HR) Pediatric and Young Adult Patients With B-cell Acute Lymphoblastic Leukemia (B-ALL) Who Are Minimal Residual Disease (MRD) Positive at the End of Consolidation (EOC) Therapy (CASSIOPEIA)

This is a single arm, open-label, multi-center, phase II study to determine the efficacy and safety of tisagenlecleucel in de novo HR pediatric and young adult B-ALL patients who received first-line treatment and are EOC MRD positive. The study will have the following sequential phases: screening, pre-treatment, treatment & follow-up, …

renal function
methotrexate
oxygen saturation
flow cytometry
gilbert's syndrome
Novartis Investigative Site
 (5.6 away) Contact site
  • 44 views
  • 24 Oct, 2022
  • +66 other locations
A Phase III Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Evaluating the Efficacy and Safety of GDC-9545 Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Patients With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer

This Phase III, randomized, double-blind, placebo-controlled, multicenter study will evaluate the efficacy and safety of giredestrant combined with palbociclib compared with letrozole combined with palbociclib in patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor-2 (HER2)-negative locally advanced (recurrent or progressed) or metastatic breast cancer.

Tom Baker Cancer Centre-Calgary
 (2.9 away) Contact site
  • 1 views
  • 24 Oct, 2022
  • +292 other locations
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus (PHOENYCS GO)

The purpose of this study is to evaluate the ability of dapirolizumab pegol (DZP) as an add-on treatment to standard of care (SOC) medication to achieve clinically relevant long term improvement of moderate to severe disease activity.

rheumatism
immunosuppressive agents
corticosteroids
sjogren's syndrome
lupus
Sl0043 50374
 (0.3 away) Contact site
  • 202 views
  • 25 Oct, 2022
  • +216 other locations
Anterior Cruciate Ligament Reconstruction Using Bone Patellar Bone or Quad Tendon Autograft With or Without Lateral Extra-Articular Tenodesis in Individuals Who Are at High Risk of Graft Failure (STABILITY 2) (STABILITY 2)

Anterior cruciate ligament (ACL) rupture is one of the most common musculoskeletal injuries in young individuals, particularly those that are active in sports. Up to 30% of individuals under the age of 20 years suffer a re-injury to the reconstructed ACL. Revision ACLR has been associated with degeneration of the …

injuries
quad
osteoarthritis
ligament reconstruction
meniscal tear
University of Calgary Sport Medicine Centre
 (3.0 away) Contact site
  • 55 views
  • 14 Oct, 2022
  • +16 other locations
A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients

This phase II trial studies how well reduced doses of radiation therapy to the brain and spine (craniospinal) and chemotherapy work in treating patients with newly diagnosed type of brain tumor called WNT)/Wingless (WNT)-driven medulloblastoma. Recent studies using chemotherapy and radiation therapy have been shown to be effective in treating …

immunohistochemistry
medulloblastoma
neutrophil count
residual tumor
x-rays
Alberta Children's Hospital
 (6.8 away) Contact site
  • 217 views
  • 14 Oct, 2022
  • +127 other locations
A Phase 3, Multicenter, Open-Label Extension Study of Oral Ozanimod for Moderately to Severely Active Crohn's Disease

This is an extension study to evaluate safety and efficacy of ozanimod in participants with moderately to severely active Crohn's Disease.

crohn's disease
remission
University of Calgary Health - The Gastrointestinal Research Group (GIRG)
 (3.0 away) Contact site
  • 1144 views
  • 18 Oct, 2022
  • +501 other locations
A Phase 2 Study to Evaluate the Efficacy and Safety of Belzutifan (MK-6482, Formerly PT2977) Monotherapy in Participants With Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), or Von Hippel-Lindau (VHL) Disease-Associated Tumors

This is a study to evaluate the efficacy and safety of Belzutifan monotherapy in participants with advanced pheochromocytoma/paraganglioma (PPGL), pancreatic neuroendocrine tumor (pNET) or von Hippel-Lindau (VHL) Disease-Associated Tumors. The primary objective of the study is to evaluate the objective response rate (ORR) of belzutifan per Response Evaluation Criteria in …

Tom Baker Cancer Center ( Site 0203)
 (2.9 away) Contact site
  • 0 views
  • 20 Oct, 2022
  • +40 other locations
Randomized, Double-Blind, 2-Arm, Multicenter, Phase 3 Study of Venetoclax and Oral Azacitidine Versus Oral Azacitidine as Maintenance Therapy for Patients With Acute Myeloid Leukemia in First Remission After Conventional Chemotherapy (VIALE-M) (VIALE-M)

This study will be conducted in two parts. Part 1 will be the Dose Confirmation portion to determine recommended Phase 3 dose (RPTD) of venetoclax in combination with AZA. Part 3 will be conducted in 2 phases - Dose Finding portion to determine RPTD of venetoclax in combination with CC-486 …

azacitidine
remission
consolidation chemotherapies
cancer
venetoclax
Tom Baker Cancer Centre /ID# 214625
 (2.9 away) Contact site
  • 49 views
  • 20 Oct, 2022
  • +133 other locations
A Phase 2/3, Multicenter, Randomized, Double-blind, Placebo-Controlled, Adaptive Design Study to Evaluate the Efficacy and Safety of MK-5475 in Adults With Pulmonary Arterial Hypertension

This is a two-part (Phase 2/Phase 3) study of MK-5475, an inhaled soluble guanylate cyclase stimulator, in participants with pulmonary arterial hypertension (PAH). The first part (Phase 2) will assess three different doses of MK-5475 compared to placebo in a base period of 12 weeks, followed by comparison of three …

heart disease
left ventricular end-diastolic pressure
right heart catheterization
body mass index
pulmonary arterial hypertension
Peter Lougheed Centre ( Site 0107)
 (4.3 away) Contact site
  • 38 views
  • 20 Oct, 2022
  • +75 other locations