Burlington, Canada Clinical Trials

A listing of Burlington, Canada clinical trials actively recruiting patients volunteers.

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Found 199 clinical trials
A Phase 2 Study to Evaluate the Efficacy and Safety of Pembrolizumab Plus Investigational Agents in Combination With Etoposide and Cisplatin or Carboplatin for the First-Line Treatment of Participants With Extensive-Stage Small Cell Lung Cancer (KEYNOTE-B99)

The purpose of this study is to evaluate the use of investigational agents (MK-4830, MK-5890 and Lenvatinib (MK-7902)) in combination with pembrolizumab and etoposide/platinum chemotherapy for the first-line treatment of participants with extensive-stage small cell Lung Cancer (ES-SCLC). No formal hypothesis testing will be performed for this study.

cancer chemotherapy
pembrolizumab
measurable disease
etoposide
carboplatin
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 2003)
 (6.3 away) Contact site
  • 0 views
  • 15 Oct, 2022
  • +43 other locations
A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients

This phase II trial studies how well reduced doses of radiation therapy to the brain and spine (craniospinal) and chemotherapy work in treating patients with newly diagnosed type of brain tumor called WNT)/Wingless (WNT)-driven medulloblastoma. Recent studies using chemotherapy and radiation therapy have been shown to be effective in treating …

blood transfusion
cancer
anticonvulsants
glomerular filtration rate
lomustine
McMaster Children's Hospital at Hamilton Health Sciences
 (6.6 away) Contact site
  • 217 views
  • 14 Oct, 2022
  • +127 other locations
Randomized, Double-Blind, 2-Arm, Multicenter, Phase 3 Study of Venetoclax and Oral Azacitidine Versus Oral Azacitidine as Maintenance Therapy for Patients With Acute Myeloid Leukemia in First Remission After Conventional Chemotherapy (VIALE-M) (VIALE-M)

This study will be conducted in two parts. Part 1 will be the Dose Confirmation portion to determine recommended Phase 3 dose (RPTD) of venetoclax in combination with AZA. Part 3 will be conducted in 2 phases - Dose Finding portion to determine RPTD of venetoclax in combination with CC-486 …

remission
azacitidine
venetoclax
cancer
consolidation chemotherapies
Juravinski Cancer Centre /ID# 214623
 (6.3 away) Contact site
  • 49 views
  • 20 Oct, 2022
  • +133 other locations
Safety and Immunogenicity of a Pneumococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Toddlers and Infants

Primary objectives: To assess the safety profile of each SP0202 formulation and Prevnar 13 in toddlers and infants (after each and any injection). To assess the immune response (serotype specific IgG concentration) of the SP0202 formulations and Prevnar 13 1 month after the administration of one dose in toddlers (Groups …

Accepts healthy volunteers
Investigational Site Number :1240006
 (5.8 away) Contact site
  • 31 views
  • 21 Oct, 2022
  • +50 other locations
A Phase 3 Randomized Study Comparing Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Ciltacabtagene Autoleucel, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against BCMA Versus Bortezomib, Lenalidomide, and Dexamethasone (VRd) Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom Hematopoietic Stem Cell Transplant is Not Planned as Initial Therapy (CARTITUDE-5)

The purpose of this study is to compare the efficacy of Bortezomib, Lenalidomide and Dexamethasone (VRd) induction followed by a single administration of ciltacabtagene autoleucel (cilta-cel) versus VRd induction followed by Lenalidomide and Dexamethasone (Rd) maintenance in newly diagnosed multiple myeloma participants for whom ASCT is not planned as initial …

chemotherapy regimen
erythropoietin
fludarabine
lenalidomide
dexamethasone
Juravinski Cancer Centre
 (6.3 away) Contact site
  • 7 views
  • 22 Oct, 2022
  • +87 other locations
Surveillance AFter Extremity Tumor surgerY (SAFETY) International Randomized Controlled Trial (SAFETY)

Following treatment for a primary extremity sarcoma, patients remain at risk for the development of local and systemic disease recurrence. Metastasis (distant recurrence) to the lung is the most frequent single location of disease recurrence in sarcoma patients, occurring in almost half of all patients. Therefore, careful post-operative surveillance is …

cancer chemotherapy
sarcoma of the extremity
metastasis
primary extremity sarcoma
sarcoma
Juravinski Hospital and Cancer Centre
 (6.3 away) Contact site
  • 0 views
  • 22 Oct, 2022
  • +24 other locations
A Randomized, Double-blind, Placebo-controlled, Parallel Group, Multicenter Phase 2a Study to Explore the Efficacy and Safety of Tezepelumab in Patients With Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) (COURSE) (COURSE)

A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase 2a Study to Explore the Efficacy and Safety of Tezepelumab in Adults with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD)

ct scan
bronchodilator
copd exacerbation
severe chronic obstructive pulmonary disease
Research Site
 (2.0 away) Contact site
  • 415 views
  • 23 Oct, 2022
  • +77 other locations
A Phase III Study of the Impact of a Physical Activity Program on Disease-Free Survival in Patients With High-Risk Stage II or Stage III Colon Cancer: A Randomized Controlled Trial (CHALLENGE)

RATIONALE: Participating in a physical activity program designed to increase free time physical activity and receiving written health education materials may influence the chance of cancer recurring as well as impact on physical fitness, psychological well-being and the quality of life of patients who have undergone surgery and chemotherapy for …

colon cancer
fatigue assessment and management
cancer
fatigue
immunomodulators
Juravinski Cancer Centre at Hamilton Health Sciences
 (6.3 away) Contact site
  • 598 views
  • 22 Oct, 2022
  • +46 other locations
A Multicenter, Open Label, Phase III Extension Trial to Study the Long-term Safety and Efficacy in Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab Trial

The purpose of this study is to evaluate the long-term safety and efficacy of pembrolizumab (MK-3475) in participants from previous Merck pembrolizumab-based parent studies who roll-over into this extension study. This study will consist of three phases: 1) First Course Phase, 2) Survival Follow-up Phase or 3) Second Course Phase. …

major surgery
mk-3475
pembrolizumab
metastasis
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 2801)
 (6.3 away) Contact site
  • 760 views
  • 21 Oct, 2022
  • +376 other locations
Melanoma Margins Trial-II - A Phase III, Multi-centre Randomised Controlled Trial Investigating 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma (02.18 MelMarT-II) (MelMarT-II)

Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the …

Hamilton Health Sciences Centre
 (6.0 away) Contact site
  • 7 views
  • 21 Oct, 2022
  • +69 other locations