Burlington, Canada Clinical Trials

A listing of Burlington, Canada clinical trials actively recruiting patients volunteers.

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Found 111 clinical trials
Study to Evaluate Adverse Events and Change in Disease Activity in Adult and Adolescent Participants With Acute Hepatitis C Virus (HCV) Infection on Treatment With Oral Tablets of Glecaprevir (GLE)/Pibrentasvir (PIB)

Hepatitis C Virus (HCV) infection is a global health problem. HCV mainly affects liver cells and causes the liver to become inflamed and damaged. This study will evaluate how safe and effective glecaprevir/pibrentasvir (GLE/PIB) is in adult and adolescent participants with acute HCV infection. GLE/PIB is an approved drug for …

Charlton Medical Centre /ID# 228100
 (6.3 away) Contact site
  • 0 views
  • 19 Sep, 2021
  • +56 other locations
Efficacy and Safety of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) Plus Chemotherapy in Participants With Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-7902-015/E7080-G000-321/LEAP-015)

The purpose of this study is to assess the efficacy and safety of lenvatinib (E7080/MK-7902) plus pembrolizumab (MK-3475) plus chemotherapy compared with chemotherapy alone in participants with advanced/metastatic gastroesophageal cancer. The primary study hypotheses are that lenvatinib plus pembrolizumab plus chemotherapy is superior to chemotherapy alone for both overall survival …

Hamilton Health Sciences - Juravinski Site ( Site 0106)
 (6.3 away) Contact site
  • 0 views
  • 19 Sep, 2021
  • +97 other locations
Study to Evaluate the Efficacy and Safety of PF-07055480 / Giroctocogene Fitelparvovec Gene Therapy in Moderately Severe to Severe Hemophilia A Adults

C3731003 is a pivotal Phase 3 study to evaluate the clinical efficacy and safety of a single IV infusion of PF-07055480 / giroctocogene fitelparvovec (Recombinant AAV2/6 Human Factor VIII Gene Therapy) in adult male participants with moderately severe or severe hemophilia A (FVIII:C1%) for the study duration of 5 years. …

severe haemophilia a
factor viii activity
antihemophilic factor
Juravinski Hospital - Hamilton Health Sciences
 (6.3 away) Contact site
  • 35 views
  • 19 Sep, 2021
  • +30 other locations
Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (KALOS)

This is a variable length study to evaluate the efficacy and safety of budesonide/glycopyrronium/formoterol inhaler in adults and adolescents with severe asthma inadequately controlled with standard of care.

Research site
 (6.2 away) Contact site
  • 5 views
  • 19 Sep, 2021
  • +339 other locations
An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Crohn's Disease

This study seeks to evaluate the safety and efficacy of brazikumab versus placebo (Stage I) and versus an active comparator (Stage 2) in participants with moderately to severely active CD and will include assessments of clinical response as demonstrated by improvement of symptoms and colonic mucosal appearance as observed on …

methotrexate
humira
crohn's disease
aminosalicylate
endoscopy
Research site
 (6.2 away) Contact site
  • 400 views
  • 19 Sep, 2021
  • +320 other locations
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer

The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming …

HER2
aromatase inhibitor
sentinel lymph node biopsy
metastasis
hormone therapy
Juravinski Cancer Centre at Hamilton Health Sciences
 (6.3 away) Contact site
  • 598 views
  • 19 Sep, 2021
  • +323 other locations
Study of MK-4830 as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-4830-001)

This study has dose escalation (Part A, B, C) and dose expansion (Cohorts A-L) parts. Dose escalation is to evaluate the safety, tolerability, and preliminary efficacy of MK-4830 monotherapy administration (Parts A and B) and in combination with pembrolizumab (Part C). Dose expansion is to evaluate the objective response rate …

HER2
adenocarcinoma
measurable disease
x-rays
antineoplastic agents
Juravinski Cancer Centre ( Site 0034)
 (6.3 away) Contact site
  • 109 views
  • 19 Sep, 2021
  • +27 other locations
Stress Hydrocortisone In Pediatric Septic Shock

SHIPSS is a multi-institutional, prospective, controlled, randomized, double-blinded interventional trial that will examine the potential benefits and risks of adjunctive hydrocortisone prescribed for children with fluid and vasoactive-inotropic refractory septic shock. It is hypothesized that adjunctive hydrocortisone will significantly reduce the proportion of children with poor outcomes, defined as death …

continuous infusion
antimicrobial agent
inotropic agent
norepinephrine
McMaster Children's Hospital
 (6.6 away) Contact site
  • 18 views
  • 07 Sep, 2021
  • +66 other locations
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes

This study will look at the long-term effects of semaglutide (active medicine) on diabetic eye disease when compared to placebo (dummy medicine). The study will be performed in people with type 2 diabetes. Participants will either get semaglutide or placebo in addition to their diabetes medicines - which treatment the …

semaglutide
hypoglycemic agents
Novo Nordisk Investigational Site
 (8.8 away) Contact site
  • 581 views
  • 19 Sep, 2021
  • +237 other locations
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer

The purpose of this study is to evaluate the effectiveness of niraparib in combination with abiraterone acetate plus prednisone (AAP) compared to AAP and placebo.

McMaster Institute of Urology
 (6.4 away) Contact site
  • 502 views
  • 19 Sep, 2021
  • +492 other locations