Brampton, Canada Clinical Trials

A listing of Brampton, Canada clinical trials actively recruiting patients volunteers.

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Found 88 clinical trials
A Study of Cotadutide in Participants Who Have Chronic Kidney Disease With Type 2 Diabetes Mellitus

A Phase 2b, study to measure the effect of Cotadutide at different doses versus placebo or comparator (semaglutide) in participants who have Chronic Kidney Disease with Type 2 Diabetes Mellitus.

semaglutide
nephropathy
sulfonylurea
thiazolidinedione
diabetes
Research Site
 (1.6 away) Contact site
  • 99 views
  • 01 Jul, 2021
  • +76 other locations
PN-943 in Adults With Moderate to Severe Active Ulcerative Colitis (UC)

The purpose of the study is to evaluate the safety, tolerability, and clinical efficacy of PN-943 450 mg twice daily [BID] and PN-943 150 mg BID, compared with placebo BID, in subjects with moderate to severe active Ulcerative Colitis (UC).

Protagonist Investigational Site
 (10.0 away) Contact site
  • 0 views
  • 21 Sep, 2021
  • +87 other locations
Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency

This study will assess the efficacy and safety of capivasertib plus abiraterone (+prednisone/prednisolone) plus androgen deprivation therapy (ADT) versus placebo plus abiraterone (+prednisone/prednisolone) plus ADT in participants with mHSPC whose tumours are characterised by PTEN deficiency. The intention of the study is to demonstrate that in participants with mHSPC, the …

Research Site
 (1.6 away) Contact site
  • 111 views
  • 18 Sep, 2021
  • +290 other locations
Study of the Efficacy and Safety of AMT-101 in Subjects With Ulcerative Colitis (LOMBARD)

Randomized, Placebo-controlled, Double-blind, Parallel-group, Multicenter, Phase 2a Study of the Efficacy and Safety of Oral AMT-101 in Subjects with Moderate to Severe Ulcerative Colitis.

Toronto Digestive Disease Associates Inc.
 (10.0 away) Contact site
  • 0 views
  • 18 Aug, 2021
  • +40 other locations
Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapy

Cancer cachexia is a multi-factorial syndrome defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment. There is an urgency for improving management, but there is no consensus on …

cancer
lung cancer
advanced cancer
targeted therapy
nutritional support
Ottawa Regional Cancer Centre
 (230.7 away) Contact site
  • 129 views
  • 14 Mar, 2021
  • +18 other locations
Acalabrutinib Safety Study in Untreated and Relapsed or Refractory Chronic Lymphocytic Leukemia Patients

This is a global, Phase 3b, multicenter, open-label, single-arm study to evaluate the safety and efficacy of acalabrutinib 100 mg bid in approximately 600 participants with chronic lymphocytic leukemia (CLL). Participants will be enrolled into 3 cohorts: treatment-naive (TN), relapsed/refractory (R/R), and prior Bruton tyrosine kinase inhibitor (BTKi) therapy. Participants …

acalabrutinib
TP53
tyrosine
lymphadenopathy
night sweats
Research Site
 (1.6 away) Contact site
  • 282 views
  • 26 Sep, 2021
  • +159 other locations
A Phase 2b Diabetic Kidney Disease Study

A Phase 2b Randomized, Double-blind, Placebo-controlled, Study to Evaluate the Efficacy and Safety of MEDI3506 in Subjects with Diabetic Kidney Disease

diabetic nephropathy
nephropathy
Research Site
 (2.4 away) Contact site
  • 54 views
  • 26 Sep, 2021
  • +115 other locations
Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With a History of Frequent Exacerbations

Phase 3 study to evaluate the efficacy and safety of a benralizumab in patients with moderate to very severe COPD with a history of frequent COPD exacerbations and elevated peripheral blood eosinophils (300/L). Eligible patients must have a history of 2 moderate and/or severe COPD exacerbations in the previous year …

eosinophil count
severe chronic obstructive pulmonary disease
bronchodilator
antibiotics
corticosteroids
Research Site
 (8.5 away) Contact site
  • 838 views
  • 10 Sep, 2021
  • +438 other locations
TAK-788 as First-line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations

The purpose of this study is to compare the efficacy of TAK-788 as first-line treatment with that of platinum-based chemotherapy in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose tumors harbor epidermal growth factor receptor (EGFR) exon 20 insertion mutations.

William Osler Health System
 (1.6 away) Contact site
  • 30 views
  • 04 Feb, 2021
  • +165 other locations
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness

The World Health Organization, U.S. Centers for Disease Control and Prevention, Association of Medical Microbiology and Infectious Diseases (AMMI) Canada, and Health Canada have all declared antimicrobial resistance a global threat to health, based on rapidly increasing resistance rates and declining new drug development. Up to 30-50% of antibiotic use …

antimicrobial agent
pneumonia
bloodstream infection
critical illness
antibiotic therapy
Trillium Health Partners
 (11.4 away) Contact site
  • 4323 views
  • 26 Sep, 2021
  • +57 other locations