Brampton, Canada Clinical Trials

A listing of Brampton, Canada clinical trials actively recruiting patients volunteers.

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Found 89 clinical trials
Study to Assess Effectiveness of GlaxoSmithKline's (GSK's) Meningococcal Group B and Combined ABCWY Vaccines in Healthy Adolescents and Young Adults.

The purpose of this study is to evaluate the effectiveness of 2 doses or 3 doses of GSK's licenced meningococcal group B Bexsero (rMenB+OMV NZ) vaccine and of 2 doses of GSK's investigational combined meningococcal (MenABCWY) vaccine (GSK3536819A) in healthy adolescents and young adults. The immunogenicity and safety will also …

conjugate vaccine
GSK Investigational Site
 (9.4 away) Contact site
  • 01 May, 2021
  • +100 other locations
CT-Perfusion for Neurological Diagnostic Evaluation

For the purpose of organ donation after neurological determination of death (NDD), death must be declared using a set of standardized clinical criteria. When a full clinical evaluation cannot be completed, additional neuroimaging ancillary testing is required. The ideal ancillary test for NDD would demonstrate no cerebral blood flow, be …

William Osler Health System
 (1.6 away) Contact site
  • 01 Aug, 2021
  • +18 other locations
Phase 2B Study to Evaluate the Efficacy of PB2452 in Reversal of Ticagrelor in Subjects Aged 50-80 Years Old

This phase 2B study is a multi-center, randomized, double-blind, placebo-controlled study. The study is designed to evaluate the efficacy of PB2452 in reversing the anti-platelet effects of ticagrelor as part of a dual antiplatelet regimen and to evaluate the safety and tolerability of PB2452 in subjects aged 50-80 years old. …

BioPharma Services Inc.
 (9.9 away) Contact site
  • 15 Jul, 2021
  • +14 other locations
Efficacy Safety and Tolerability of AZD9977 and Dapagliflozin in Participants With Heart Failure and Chronic Kidney Disease

The purpose of the study is to evaluate the efficacy and safety of AZD9977 alone and AZD9977 in combination with dapagliflozin and to assess the dose-response relationship of placebo, AZD9977 alone, dapagliflozin alone and 3 doses of AZD9977 combined with dapagliflozin on urinary albumin to creatinine ratio (UACR). The study …

body mass index
heart failure
natriuretic peptide
antihypertensive drugs
Research Site
 (1.6 away) Contact site
  • 29 Aug, 2021
  • +141 other locations
An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis

The present study D5272C00001 (Legacy # 3151-201-008) seeks to evaluate the efficacy and safety of brazikumab versus placebo in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy.

Research Site
 (10.0 away) Contact site
  • 29 Jan, 2021
  • +67 other locations
Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Crohn's Disease

The primary objectives of this study are to evaluate the safety and efficacy of filgotinib during induction and maintenance treatment of moderately to severely active Crohn's disease (CD) in participants who are biologic-naive and biologic-experienced. Participants who complete the study, or do not meet protocol response or remission criteria at …

tumour necrosis
crohn's disease
Toronto Digestive Disease Associates Inc.
 (10.0 away) Contact site
  • 04 Jul, 2021
  • +551 other locations
Study to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic HFrEF Receiving Spironolactone

The main objective of this study is to evaluate the efficacy of SZC as compared with placebo in keeping potassium levels within the normal range (3.5-5.0 mEq/L) while on spironolactone 25 mg daily without assistance of rescue therapy for hyperkalaemia (HK).

Research Site
 (1.6 away) Contact site
  • 29 Aug, 2021
  • +52 other locations
EMPACT-MI: A Study to Test Whether Empagliflozin Can Lower the Risk of Heart Failure and Death in People Who Had a Heart Attack (Myocardial Infarction)

This is a study in adults who had a heart attack (myocardial infarction). The purpose of this study is to find out whether a medicine called empagliflozin helps to lower the chances of having to go to the hospital for heart failure and whether it lowers the chances of dying …

myocardial infarction
heart failure
cardiovascular disease
William Osler Health Centre
 (3.5 away) Contact site
  • 17 Sep, 2021
  • +237 other locations
DOuble SEquential External Defibrillation for Refractory VF

Despite significant advances in resuscitation efforts, there are some patients who remain in refractory ventricular fibrillation (VF) during out-of-hospital cardiac arrest. Double sequential external defibrillation (DSED) and vector change defibrillation have been proposed as viable options for patients in refractory VF. This cluster randomized trial will compare (1) continued resuscitation …

ventricular tachycardia
Halton Region Paramedic Services
 (18.6 away) Contact site
  • 02 Aug, 2021
  • +3 other locations
Safety and Efficacy of AT-001 in Patients With Diabetic Cardiomyopathy

This is a multicenter, randomized, placebo-controlled, 2-part study to evaluate the safety and efficacy of AT-001 in adult patients (N=675) with Diabetic Cardiomyopathy at high risk of progression to overt heart failure.

heart failure
LMC Diabetes & Endocrinology Ltd. - Brampton
 (2.7 away) Contact site
  • 21 Jun, 2021
  • +79 other locations