Preston, Australia Clinical Trials

A listing of Preston, Australia clinical trials actively recruiting patients volunteers.

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Found 223 clinical trials
A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH)

This is a prospective, multicenter, open-label, randomized, controlled, parallel group, group-sequential, event-driven Phase 3 study to evaluate efficacy, safety and pharmacokinetics (PK) of macitentan in children.

heart disease
hypertension
macitentan
connective tissue disease
Royal Children's Hospital Melbourne - PIN
 (4.4 away) Contact site
  • 172 views
  • 16 Jun, 2021
  • +106 other locations
A Study of BR Alone Versus in Combination With Acalabrutinib in Subjects With Previously Untreated MCL

This study is evaluating the efficacy of acalabrutinib in combination with bendamustine and rituximab (BR) compared with placebo plus BR in subjects with previously untreated mantle cell lymphoma.

bendamustine
acalabrutinib
cyclin d1
rituximab
Research Site
 (8.4 away) Contact site
  • 1270 views
  • 15 May, 2021
  • +245 other locations
Study to Assess Effectiveness of GlaxoSmithKline's (GSK's) Meningococcal Group B and Combined ABCWY Vaccines in Healthy Adolescents and Young Adults.

The purpose of this study is to evaluate the effectiveness of 2 doses or 3 doses of GSK's licenced meningococcal group B Bexsero (rMenB+OMV NZ) vaccine and of 2 doses of GSK's investigational combined meningococcal (MenABCWY) vaccine (GSK3536819A) in healthy adolescents and young adults. The immunogenicity and safety will also …

bexsero
vaccination
menacwy
conjugate vaccine
GSK Investigational Site
 (6.2 away) Contact site
  • 0 views
  • 01 May, 2021
  • +100 other locations
Study of Trastuzumab Deruxtecan (T-DXd) vs Investigator's Choice Chemotherapy in HER2-low Hormone Receptor Positive Metastatic Breast Cancer

This study will evaluate the efficacy, safety and tolerability of trastuzumab deruxtecan compared with investigator's choice chemotherapy in human epidermal growth factor receptor (HER)2-low, hormone receptor (HR) positive breast cancer patients whose disease has progressed on endocrine therapy in the metastatic setting.

Research Site
 (4.3 away) Contact site
  • 35 views
  • 24 May, 2021
  • +245 other locations
Extending the Time Window for Tenecteplase by Effective Reperfusion in Patients With Large Vessel Occlusion

Patients presenting to the emergency department with an acute ischemic stroke due to a large vessel occlusion eligible for thrombectomy and target mismatch on computed tomography perfusion imaging within 24 hours of onset will be assessed determine their eligibility for randomization into the trial. If the patient gives informed consent …

plasminogen
stenosis
alteplase
stroke
thrombolytic agent
Royal Melbourne Hospital
 (4.8 away) Contact site
  • 0 views
  • 26 Jan, 2021
  • +3 other locations
Study of Capmatinib Efficacy in Comparison With Docetaxel in Previously Treated Participants With Non-small Cell Lung Cancer Harboring MET Exon 14 Skipping Mutation

The purpose of the study is to learn whether the study drug (capmatinib) helps to control lung cancer better compared to a single agent chemotherapy (docetaxel) and whether it is safe when given to patients suffering from a particular type of lung cancer. This type of cancer is called non-small …

measurable disease
epidermal growth factor receptor
epidermal growth factor
cancer chemotherapy
growth factor
Novartis Investigative Site
 (5.5 away) Contact site
  • 0 views
  • 13 Jun, 2021
  • +42 other locations
Efficacy and Safety APT-1011 in Subjects With Eosinophilic Esophagitis (EoE) (FLUTE-2)

This is a 2-part randomized, double-blind, placebo-controlled study of APT-1011 in adults and adolescents (12 years) with EoE. Part A will evaluate the efficacy and safety of APT-1011 3 mg administered HS for the induction of response to treatment (histologic and symptomatic) over 12 weeks. Part B will evaluate histological …

esophagogastroduodenoscopy
dysphagia
St. Vincent's Hospital
 (4.3 away) Contact site
  • 93 views
  • 14 Jun, 2021
  • +141 other locations
A Study of Guselkumab in Participants With Active Psoriatic Arthritis

The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA.

polyarticular arthritis
psoriatic plaque
apremilast
arthritis mutilans
DMARD
Emeritus Research
 (9.5 away) Contact site
  • 0 views
  • 16 Jun, 2021
  • +207 other locations
Radiotherapy or Imiquimod in Complex Lentigo Maligna

The purpose of this study is to investigate the effectiveness of using either radiotherapy (RT) or Imiquimod (ImiQ) to treat the Lentigo Maligna (LM), when surgery is not possible, is refused, or fails.

The Alfred Hospital
 (6.2 away) Contact site
  • 19 views
  • 21 Apr, 2021
  • +9 other locations
Neuraxial Pethidine After Lumbar Surgery Trial

The hypothesis is that epidural pethidine is an effective form of pain relief following lumbar spinal surgery, resulting in significantly lower usage of concomitantly administered (intravenous) patient-controlled analgesia (PCA) pethidine.

analgesia
pain relief
Austin Health
 (3.8 away) Contact site
  • 55 views
  • 07 Nov, 2020
  • 1 location