Paramatta, Australia Clinical Trials

A listing of Paramatta, Australia clinical trials actively recruiting patients volunteers.

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Found 387 clinical trials
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Study of Oral Navitoclax Tablet In Combination With Oral Ruxolitinib Tablet When Compared With Oral Ruxolitinib Tablet To Assess Change In Spleen Volume In Adult Participants With Myelofibrosis

www.MyelofibrosisResearch.com Myelofibrosis is a type of bone marrow cancer that usually develops slowly and disrupts body's normal production of blood cells. It causes bone marrow scarring, leading to severe anemia that can cause weakness and fatigue. It can also cause a low number of blood-clotting cells called platelets, which increases …

Liverpool Hospital /ID# 221803
 (9.2 away) Contact site
  • 32 views
  • 29 Apr, 2021
  • +148 other locations
A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations

The purpose of this study is to evaluate efficacy of erdafitinib versus chemotherapy or pembrolizumab in participants with advanced urothelial cancer harboring selected fibroblast growth factor receptor (FGFR) aberrations who have progressed after 1 or 2 prior treatments, at least 1 of which includes an anti-programmed death ligand 1(PD-[L]1) agent …

adjuvant chemotherapy
transitional cell carcinoma
vinflunine
pembrolizumab
renal function
Macquarie University
 (6.0 away) Contact site
  • 271 views
  • 03 Jun, 2021
  • +587 other locations
DIRECT-SAFE: A Randomized Controlled Trial of DIRECT Endovascular Clot Retrieval Versus Standard Bridging Thrombolysis With Endovascular Clot Retrieval

The study will be a multicentre, prospective, randomized, open label, blinded endpoint (PROBE) phase 3 trial (2 arm with 1:1 randomization) in ischemic stroke patients within 4.5 hours of stroke onset. Randomised patients will be stratified for site of baseline arterial occlusion into one of three groups: 1. internal carotid …

probe
arterial occlusion
stroke
clot
Liverpool Hospital
 (8.5 away) Contact site
  • 129 views
  • 15 Feb, 2021
  • +34 other locations
Trial in Non-cystic Fibrosis Bronchiectasis Patients With Chronic Lung Infections Treated With Colistimethate Sodium (PROMIS II)

The primary objectives of the trial is to investigate the effect of the use of inhaled colistimethate sodium, administered twice daily via the I-neb for 12 months, compared to placebo in subjects with non-cystic fibrosis bronchiectasis (NCFB) chronically infected with P. aeruginosa on the frequency of pulmonary exacerbations.

Zambon Investigative Site
 (7.3 away) Contact site
  • 155 views
  • 24 Jan, 2021
  • +107 other locations
Safety and Effectiveness of the XEN45 Glaucoma Treatment System in Patients With Angle Closure Glaucoma

This study will evaluate the safety and IOP-lowering effectiveness of XEN in patients with Angle Closure Glaucoma.

Marsden Eye Specialist
 (0.2 away) Contact site
  • 161 views
  • 18 Apr, 2021
  • +31 other locations
Androgen Deprivation Therapy in Treating Patients With Prostate Cancer

RATIONALE: Androgens can cause the growth of prostate cancer cells. Androgen deprivation therapy may stop the adrenal glands from making androgens. PURPOSE: This randomized phase III trial is studying how well androgen deprivation therapy works in treating patients with prostate cancer.

epinephrine
androgens
antiandrogen therapy
orchiectomy
antiandrogens
Cancer Therapy Centre at Liverpool Hospital
 (8.5 away) Contact site
  • 401 views
  • 07 Nov, 2020
  • +8 other locations
Comparison of VT Ablation Outcomes Using Remote MAGNETIC Navigation Versus Manual Approach in a Low LVEF Population

The study purpose is to demonstrate that ventricular tachycardia (VT) ablation using the Niobe ES system results in superior outcomes compared to a manual approach in subjects with ischemic scar VT in a low ejection fraction population.

catheter ablation
myocardial infarction
ejection fraction
scar
infarct
Westmead Hospital
 (1.2 away) Contact site
  • 0 views
  • 24 Jan, 2021
  • +16 other locations
Study of REGN2810 in Patients With Advanced Cutaneous Squamous Cell Carcinoma

For Groups 1 to 4, the primary objective of this study is to estimate the clinical benefit of cemiplimab monotherapy for patients with: metastatic (nodal or distant) cutaneous squamous cell carcinoma (CSCC), or unresectable locally advanced CSCC. For Group 6, the primary objective is to provide additional efficacy and safety …

Liverpool Hospital
 (9.2 away) Contact site
  • 0 views
  • 28 Jan, 2021
  • +102 other locations
Vinblastine +/- Bevacizumab in Children With Unresectable or Progressive Low Grade Glioma (LGG)

This is an open-label, randomized, multi-center, comparator Phase II trial looking at the addition of Bevacizumab to Vinblastine in chemotherapy nave pediatric patients with progressive Low Grade Glioma aged 6 months to less than18 years of age at the time of initiation of therapy. Participants will be randomized to Arm …

neutrophil count
platelet count
BRAF
progressive disease
auditory test
Children's Hospital at Westmead
 (0.9 away) Contact site
  • 0 views
  • 24 Jan, 2021
  • +23 other locations
A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH)

This is a prospective, multicenter, open-label, randomized, controlled, parallel group, group-sequential, event-driven Phase 3 study to evaluate efficacy, safety and pharmacokinetics (PK) of macitentan in children.

hypertension
heart disease
connective tissue disease
macitentan
Children's Hospital at Westmead
 (0.9 away) Contact site
  • 172 views
  • 30 May, 2021
  • +104 other locations