Paramatta, Australia Clinical Trials

A listing of Paramatta, Australia clinical trials actively recruiting patients volunteers.

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Found 30 clinical trials
Study of Quavonlimab (MK-1308) in Combination With Pembrolizumab (MK-3475) in Advanced Solid Tumors (MK-1308-001)

This study will assess the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of escalating doses of quavonlimab when used in combination with pembrolizumab in participants with advanced solid tumors.

Blacktown Hospital. Western Sydney local health district ( Site 0009)
 (6.2 away) Contact site
  • 742 views
  • 12 Jun, 2021
  • +52 other locations
CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Synovial Sarcoma

This study is being conducted to test the safety and efficacy of ramucirumab in combination with other chemotherapy in the treatment of relapsed, recurrent, or refractory synovial sarcoma (SS) in children and young adults. This trial is part of the CAMPFIRE master protocol which is a platform to accelerate the …

The Sydney Children's Hospitals Network
 (0.9 away) Contact site
  • 0 views
  • 13 Jun, 2021
  • +67 other locations
A Study to Evaluate the Safety and Tolerability of EXN407

This first in human (FIH), Phase Ib/II study of EXN407 is a randomised, double-masked, vehicle-controlled, multiple dose, dose-escalating study to evaluate the safety and tolerability of EXN407 in subjects with centre involved Diabetic Macular Oedema (DMO), with Centre-subfield macular thickness (CMT) between 280-420 m and Best corrected visual acuity (BCVA) …

Strathfield Retina Clinic
 (6.2 away) Contact site
  • 0 views
  • 13 Jun, 2021
  • +8 other locations
Study of Intra-Arterial Oxaliplatin Plus Capecitabine to Treat Liver Metastases From Colorectal Cancer

The treatment proposed in this trial is to administer intra-arterial chemotherapy to liver metastases from colorectal cancer when the blood flow to and from the liver has been isolated via balloon catheters through a vascular access system called the AVAS. The objective of this study is to evaluate the tumour …

Macquarie University Hospital
 (7.0 away) Contact site
  • 0 views
  • 27 Jan, 2021
  • +1 other locations
Umbrella Study of Sasanlimab Combined With Targeted Therapies in Participants With Non Small Cell Lung Cancer

Phase 1b/Phase 2 open-label, multi-center, parallel group umbrella study. Sasanlimab (a PD-1 antagonist monoclonal antibody) will be combined with a different targeted therapy in each sub-study. The Phase1b part of each sub-study will evaluate the safety of the combination and select the dose for the Phase 2 part. The Phase …

lung carcinoma
cancer chemotherapy
measurable disease
Concord Hospital
 (6.5 away) Contact site
  • 0 views
  • 13 Jun, 2021
  • +39 other locations
To Evaluate the Safety Pharmacokinetics Pharmacodynamics and Antitumor Activity of ABN401 in Patients With Advanced Solid Tumors

This is a dose escalation, Phase 1-2 study of ABN401 in patients with advanced solid tumors, refractory metastatic disease, or refractory locally advanced disease not amenable to local therapy.

Sydney Southwest Private Hospital
 (9.2 away) Contact site
  • 3 views
  • 24 Jan, 2021
  • +7 other locations
Safety and Efficacy of SX600 Administered by Lumbosacral Transforaminal Epidural Injection for Radicular Pain

This is a Phase I/II, double-blind, parallel-group, randomized, placebo-controlled multi-centre trial in 180 patients randomized 1:1:1 to receive the IMP (Dexamethasone acetate microspheres for extended-release injectable micro-suspension, SX600 at 12.5 mg or 25.0 mg) or Placebo (0.9% Sodium Chloride for Injection, BP) via transforaminal epidural injection to the lumbosacral epidural …

Research Site 10
 (6.4 away) Contact site
  • 70 views
  • 27 Jan, 2021
  • +10 other locations
A Study of PRN1008 in Adult Patients With Immune Thrombocytopenia (ITP)

This is a 2 part (Part A and B) adaptive, open-label, dose-finding study of PRN1008 in patients with ITP who are refractory or relapsed with no available and approved therapeutic options, with a platelet count <30,000/L on two counts no sooner than 7 days apart in the 15 days before …

autoimmune thrombocytopenia
platelet count
thrombocytopenia
Central Recruiting (Principia Biopharma)
 (6.7 away) Contact site
  • 450 views
  • 28 May, 2021
  • +63 other locations
Phase 1/2 Dose Finding and Safety Study of Ibrutinib in Pediatric Subjects With Chronic Graft Versus Host Disease (cGVHD)

Dose Finding and Safety Study of Ibrutinib in Pediatric Subjects with Chronic Graft Versus Host Disease (cGVHD)

cell transplantation
ibrutinib
immunosuppression
Cancer Center for Children. The Children's Hospital at Westmead
 (0.9 away) Contact site
  • 47 views
  • 24 Jan, 2021
  • +49 other locations
Study to Evaluate the Safety and Efficacy of a Combination of Favezelimab (MK-4280) and Pembrolizumab (MK-3475) in Participants With Hematologic Malignancies (MK-4280-003)

This study will evaluate the safety and efficacy of favezelimab in combination with pembrolizumab (MK-3475) in participants with hematological malignancies: classical Hodgkin lymphoma (cHL) diffuse large B-cell lymphoma (DLBCL) indolent non-Hodgkin lymphoma (iNHL) The study will have 2 phases: a safety lead-in and an efficacy expansion phase. The recommended Phase …

lymphoma
hodgkin's disease
pembrolizumab
b-cell lymphoma
large b-cell lymphoma
Concord Repatriation & General Hospital ( Site 0203)
 (5.6 away) Contact site
  • 45 views
  • 03 Jun, 2021
  • +24 other locations