Paramatta, Australia Clinical Trials

A listing of Paramatta, Australia clinical trials actively recruiting patients volunteers.

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Found 429 clinical trials
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Study of Oral Navitoclax Tablet In Combination With Oral Ruxolitinib Tablet When Compared With Oral Ruxolitinib Tablet To Assess Change In Spleen Volume In Adult Participants With Myelofibrosis

www.MyelofibrosisResearch.com Myelofibrosis is a type of bone marrow cancer that usually develops slowly and disrupts body's normal production of blood cells. It causes bone marrow scarring, leading to severe anemia that can cause weakness and fatigue. It can also cause a low number of blood-clotting cells called platelets, which increases …

Liverpool Hospital /ID# 221803
 (9.2 away) Contact site
  • 39 views
  • 29 Apr, 2021
  • +148 other locations
Comparison of VT Ablation Outcomes Using Remote MAGNETIC Navigation Versus Manual Approach in a Low LVEF Population

The study purpose is to demonstrate that ventricular tachycardia (VT) ablation using the Niobe ES system results in superior outcomes compared to a manual approach in subjects with ischemic scar VT in a low ejection fraction population.

myocardial infarction
ejection fraction
scar
catheter ablation
infarct
Westmead Hospital
 (1.2 away) Contact site
  • 0 views
  • 24 Jan, 2021
  • +16 other locations
Study of REGN2810 in Patients With Advanced Cutaneous Squamous Cell Carcinoma

For Groups 1 to 4, the primary objective of this study is to estimate the clinical benefit of cemiplimab monotherapy for patients with: metastatic (nodal or distant) cutaneous squamous cell carcinoma (CSCC), or unresectable locally advanced CSCC. For Group 6, the primary objective is to provide additional efficacy and safety …

Liverpool Hospital
 (9.2 away) Contact site
  • 0 views
  • 28 Jan, 2021
  • +102 other locations
Vinblastine +/- Bevacizumab in Children With Unresectable or Progressive Low Grade Glioma (LGG)

This is an open-label, randomized, multi-center, comparator Phase II trial looking at the addition of Bevacizumab to Vinblastine in chemotherapy nave pediatric patients with progressive Low Grade Glioma aged 6 months to less than18 years of age at the time of initiation of therapy. Participants will be randomized to Arm …

BRAF
corticosteroids
platelet count
progressive disease
glomerular filtration rate
Children's Hospital at Westmead
 (0.9 away) Contact site
  • 0 views
  • 24 Jan, 2021
  • +23 other locations
A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH)

This is a prospective, multicenter, open-label, randomized, controlled, parallel group, group-sequential, event-driven Phase 3 study to evaluate efficacy, safety and pharmacokinetics (PK) of macitentan in children.

connective tissue disease
hypertension
macitentan
heart disease
Children's Hospital at Westmead
 (0.9 away) Contact site
  • 172 views
  • 16 Jun, 2021
  • +106 other locations
A Study of BR Alone Versus in Combination With Acalabrutinib in Subjects With Previously Untreated MCL

This study is evaluating the efficacy of acalabrutinib in combination with bendamustine and rituximab (BR) compared with placebo plus BR in subjects with previously untreated mantle cell lymphoma.

acalabrutinib
bendamustine
rituximab
cyclin d1
Research Site
 (3.0 away) Contact site
  • 1270 views
  • 24 Jul, 2021
  • +250 other locations
Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease

Individuals receiving dialysis are at risk of heart failure and heart related death. There is an urgent need for treatments that reduce the risk of these problems in patients that require dialysis. Spironolactone is a pill used to prevent heart failure and related deaths in patients that do not require …

Concord Repatriation General Hospital
 (6.5 away) Contact site
  • 41 views
  • 26 Jan, 2021
  • +97 other locations
Trial of EXenatide in Acute Ischaemic Stroke

Overview: Elevated blood glucose levels are common in many acute diseases, resulting in worse clinical outcomes. Hyperglycaemia in acute ischaemic stroke (post-stroke hyperglycaemia [PSH]) occurs in up to 50% patients, reduces the efficacy of stroke thrombolysis with increased risk of haemorrhage, increases infarct size, and results in worse clinical outcomes …

Liverpool Hospital
 (8.5 away) Contact site
  • 2 views
  • 23 Jan, 2021
  • +15 other locations
EXamining PErsonalised Radiation Therapy for Low-risk Early Breast Cancer

This is a randomised, phase III, non-inferiority trial evaluating radiation therapy versus observation following breast conserving surgery and planned endocrine therapy in patients with stage I breast cancer of luminal A subtype defined using the Prosigna (PAM50) Assay.

Westmead Hospital
 (1.2 away) Contact site
  • 685 views
  • 22 Apr, 2021
  • +46 other locations
Androgen Deprivation Therapy in Treating Patients With Prostate Cancer

RATIONALE: Androgens can cause the growth of prostate cancer cells. Androgen deprivation therapy may stop the adrenal glands from making androgens. PURPOSE: This randomized phase III trial is studying how well androgen deprivation therapy works in treating patients with prostate cancer.

epinephrine
orchiectomy
antiandrogen therapy
androgens
antiandrogens
Cancer Therapy Centre at Liverpool Hospital
 (8.5 away) Contact site
  • 401 views
  • 07 Nov, 2020
  • +8 other locations