North Ryde, Australia Clinical Trials

A listing of North Ryde, Australia clinical trials actively recruiting patients volunteers.

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Found 221 clinical trials
Defining the Clinical Role of Topiramate in the Treatment of Alcohol Dependence in Australia

To compare the clinical effectiveness, tolerability, and cost-effectiveness of topiramate to active control (naltrexone) on treatment outcomes for alcohol dependence in a double-blind randomised controlled trial.

alcohol use disorder
naltrexone
topiramate
heavy drinking
alcoholism
Drug Health Services, Royal Prince Alfred Hospital
 (7.5 away) Contact site
  • 293 views
  • 08 Nov, 2020
  • 1 location
PAEAN - Erythropoietin for Hypoxic Ischaemic Encephalopathy in Newborns

Double-blind, placebo controlled Phase III trial of erythropoietin for hypoxic ischaemic encephalopathy in infants receiving hypothermia. The study aim is to determine whether Epo in conjunction with hypothermia in infants with moderate/severe hypoxic ischaemic encephalopathy (HIE) will improve neurodevelopmental outcomes at 2 years of age, without significant adverse effects, when …

hypothermia
base deficit
at 10
hypoxia
severe hypoxic-ischemic encephalopathy
Royal North Shore Hospital
 (4.8 away) Contact site
  • 72 views
  • 14 Jul, 2019
  • +24 other locations
Adding Mitomycin C to Bacillus of Calmette-Guerin (BCG) as Adjuvant Intravesical Therapy for High-risk Non-Muscle-invasive Bladder Cancer

Open label, randomised phase 3 trial of the addition of Mitomycin C to BCG as adjuvant intravesical therapy for high-risk, non-muscle-invasive bladder cancer. The study aim is to compare disease-free survival between treatment arms: BCG alone versus Mitomyicn C in addition to BCG.

bladder tumor
bladder cancer
cystoscopy
cancer
transurethral resection
Concord Repatriation General Hospital
 (3.5 away) Contact site
  • 16 views
  • 08 Nov, 2020
  • 1 location
International Randomised Phase III Clinical Trial in Children With Acute Myeloid Leukaemia

The main purpose of this study is : To establish which number of doses of gemtuzumab ozogamicin (up to a maximum of 3 doses) is tolerated and can be safety delivered in combination with cytarabine plus mitoxantrone or liposomal daunorubicin in induction To compare mitoxantrone (anthracenedione) & cytarabine with liposomal …

induction chemotherapy
gilbert's syndrome
fludarabine
remission
idarubicin
The Childrens Hospital at Westmead
 (7.9 away) Contact site
  • 0 views
  • 16 Nov, 2020
  • +58 other locations
A Study to Evaluate the Safety Pharmacokinetics and Pharmacodynamics of Ivacaftor in Subjects With Cystic Fibrosis Who Are Less Than 24 Months of Age and Have an Ivacaftor-Responsive CFTR Mutation

The purpose of this study is to evaluate the safety of ivacaftor treatment, and PK of ivacaftor and metabolites in subjects with cystic fibrosis (CF) who are <24 months of age at treatment initiation and have an ivacaftor-responsive CF transmembrane conductance regulator (CFTR) gene mutation.

ivacaftor
sweat test
fibrosis
 (7.9 away) Contact site
  • 0 views
  • 30 Dec, 2020
  • +22 other locations
Long-term Safety of Tafamidis in Subjects With Transthyretin Cardiomyopathy

Open label study to evaluate tafamidis for the treatment of transthyretin cardiomyopathy

Westmead Hospital
 (7.7 away) Contact site
  • 0 views
  • 17 Jan, 2021
  • +143 other locations
Efficacy and Safety Study of Maribavir Compared to Valganciclovir for the Treatment of Cytomegalovirus (CMV) Infection in Hematopoietic Stem Cell Transplant Recipients

The purpose of this study is to compare the efficacy of maribavir to valganciclovir for the treatment of cytomegalovirus (CMV) infection in asymptomatic hematopoietic stem cell transplant (HSCT) recipients.

Westmead Hospital
 (7.9 away) Contact site
  • 746 views
  • 28 Dec, 2020
  • +137 other locations
Randomized Open Label Clinical Study of the Targeted Therapy Palbociclib to Treat Metastatic Breast Cancer

The primary objective of this study is to demonstrate that the combination of palbociclib with anti-HER2 therapy plus endocrine therapy is superior to anti-HER2-based therapy plus endocrine therapy alone in improving the outcomes of subjects with hormone receptor-positive, HER2+ metastatic breast cancer.

endocrine therapy
anastrozole
trastuzumab
fulvestrant
HER2
Westmead Hospital
 (7.9 away) Contact site
  • 544 views
  • 02 Dec, 2020
  • +131 other locations
Study of AG-120 (Ivosidenib) vs. Placebo in Combination With Azacitidine in Patients With Previously Untreated Acute Myeloid Leukemia With an IDH1 Mutation

Study AG120-C-009 is a global, Phase 3, multicenter, double-blind, randomized, placebo-controlled clinical trial to evaluate the efficacy and safety of AG-120 (ivosidenib) + azacitidine vs placebo + azacitidine in adult participants with previously untreated IDH1m AML who are considered appropriate candidates for non-intensive therapy. The primary endpoint is event-free survival …

induction chemotherapy
carbon monoxide
azacitidine
blast cells
remission
Royal Prince Alfred Hospital
 (7.6 away) Contact site
  • 1690 views
  • 30 Dec, 2020
  • +234 other locations
Efficacy and Safety of FG-4592 for Treatment of Anemia in Patients With Lower Risk MDS With Low Red Blood Cell Transfusion Burden

The purpose of this study is to determine whether FG-4592 is safe and effective in the treatment of anemia in patients with Lower Risk Myelodysplastic Syndrome and Low Red Blood Cell Transfusion Burden.

Investigational Site
 (8.2 away) Contact site
  • 44 views
  • 04 Nov, 2020
  • +74 other locations