North Ryde, Australia Clinical Trials

A listing of North Ryde, Australia clinical trials actively recruiting patients volunteers.

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Found 223 clinical trials
Pivotal Study to Assess the Efficacy Safety and Tolerability of Dupilumab in Patients With Moderate to Severe COPD With Type 2 Inflammation

Primary Objective: To evaluate the efficacy of dupilumab administered every 2 weeks in patients with moderate or severe Chronic Obstructive Pulmonary Disease (COPD) as measured by Annualized rate of acute moderate or severe COPD exacerbation (AECOPD) Secondary Objectives: To evaluate the effect of dupilumab administered every 2 weeks on Pre-bronchodilator …

bronchodilator
cough
copd exacerbation
muscarinic antagonists
eosinophil count
Investigational Site Number 0360003
 (7.7 away) Contact site
  • 156 views
  • 17 Jan, 2021
  • +172 other locations
A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease

The reason for this study is to determine the long-term efficacy and safety of the study drug mirikizumab in participants with Crohn's disease.

crohn's disease
Concord Repatriation General Hospital
 (4.4 away) Contact site
  • 22 views
  • 16 Jan, 2021
  • +211 other locations
Study of Abrocitinib Compared With Dupilumab in Adults With Moderate to Severe Atopic Dermatitis on Background Topical Therapy

This is a randomized, double-blind, double-dummy, active-controlled, multi-center study to assess the efficacy and safety of abrocitinib 200 mg (2 x 100 mg tablets) administered orally QD compared with dupilumab 300 mg administered by subcutaneous injection every other week (as per label guidelines) in adult participants on background topical therapy, …

eczema
dupilumab
atopy
topical agents
hand dermatitis
Royal North Shore Hospital
 (4.8 away) Contact site
  • 144 views
  • 17 Jan, 2021
  • +180 other locations
Study of Safety Efficacy and Tolerability of Secukinumab Versus Placebo in Combination With SoC Therapy in Patients With Active Lupus Nephritis

The purpose of this trial is to evaluate the efficacy and safety of subcutaneous secukinumab 300 mg compared to placebo, in combination with standard of care therapy (SoC), in subjects with active lupus nephritis (ISN/RPS Class III or IV, with or without co-existing class V features).

mammogram
glomerular filtration rate
urinary sediment
nephritis
Novartis Investigative Site
 (7.7 away) Contact site
  • 37 views
  • 17 Dec, 2020
  • +56 other locations
Preventing Adverse Cardiac Events in COPD

A double-blind, randomised controlled trial in participants with COPD to assess the efficacy of proactive treatment of cardiac risk in people with COPD. We hypothesise that treating known and undiagnosed CVD in COPD participants will improve both cardiac and respiratory outcomes.

bronchodilator
hypertension
copd exacerbation
heart disease
antibiotics
Concord Repatriation General Hospital
 (7.3 away) Contact site
  • 30 views
  • 23 Jul, 2020
  • +16 other locations
The Fenofibrate And Microvascular Events in Type 1 Diabetes Eye.

The purpose of this study is to evaluate the potential benefits of 145 mg of daily fenofibrate in adults with type 1 diabetes mellitus and pre-existing non-proliferative diabetic retinopathy.

Concord Repatriation General Hospital
 (3.5 away) Contact site
  • 0 views
  • 10 Dec, 2020
  • +20 other locations
Study to Evaluate the Efficacy and Safety of Valoctocogene Roxaparvovec With Prophylactic Steroids in Hemophilia A

This Phase III clinical study will evaluate the safety and effectiveness of valoctocogene roxaparvovec in combination with prophylactic corticosteroids in patients with severe hemophilia A.

Royal Prince Alfred Hospital
 (7.3 away) Contact site
  • 0 views
  • 17 Jan, 2021
  • +4 other locations
A Trial of E7777 in Persistent and Recurrent Cutaneous T-Cell Lymphoma

The purpose of this trial is to assess the efficacy of E7777 in participants with recurrent or persistent Cutaneous T-Cell Lymphoma (CTCL) in Stage I - III participants as assessed by objective response rate (ORR). A lead-in dose-finding part was used to determine dose level 9 microgram per kilogram (mcg/kg) …

Westmead Hospital
 (7.9 away) Contact site
  • 181 views
  • 15 Oct, 2020
  • +22 other locations
Accelerated v's Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours

The purpose of this study is to determine whether accelerated BEP chemotherapy is more effective than standard BEP chemotherapy in males with intermediate and poor-risk metastatic germ cell tumours.

pegfilgrastim
filgrastim
mg++
renal function
g-csf
Macquarie Cancer Clinical Trials
 (1.3 away) Contact site
  • 50 views
  • 12 Nov, 2020
  • +24 other locations
Cystic Fibrosis - Insulin Deficiency Early Action

Cystic Fibrosis (CF) is the most common life-threatening genetic condition affecting Australian children. As well as repeated lung infections, children with CF develop insulin deficiency and eventually diabetes. The CF-IDEA trial (Cystic Fibrosis - Insulin Deficiency, Early Action) will determine whether starting insulin treatment before the onset of diabetes (earlier …

insulin
malnutrition
oral glucose tolerance test
genetic disorder
antibiotics
Children's Hospital at Westmead
 (7.9 away) Contact site
  • 50 views
  • 22 Jan, 2021
  • +4 other locations