North Ryde, Australia Clinical Trials

A listing of North Ryde, Australia clinical trials actively recruiting patients volunteers.

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Found 213 clinical trials
Efficacy and Safety of Pembrolizumab (MK-3475) Plus Enzalutamide Plus Androgen Deprivation Therapy (ADT) Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) (MK-3475-991/KEYNOTE-991)

This study will assess the efficacy and safety of pembrolizumab plus enzalutamide plus ADT versus placebo plus enzalutamide plus ADT in participants with mHSPC. The primary hypothesis is that in participants with mHSPC, the combination of pembrolizumab plus enzalutamide plus ADT is superior to placebo plus enzalutamide plus ADT with …

Chris OBrien Lifehouse ( Site 0300)
 (7.3 away) Contact site
  • 272 views
  • 25 Nov, 2020
  • +175 other locations
A Study to Assess the Effectiveness and Safety of Irinotecan Liposome Injection 5-fluorouracil/Leucovorin Plus Oxaliplatin in Patients Not Previously Treated for Metastatic Pancreatic Cancer Compared to Nab-paclitaxel+Gemcitabine Treatment

The purpose of this study is to look at the efficacy and safety of Irinotecan liposome injection in combination with other approved drugs used for cancer therapy, namely 5 fluorouracil/leucovorin (5FU/LV) plus oxaliplatin compared to nab-paclitaxel + gemcitabine treatment in improving the overall survival of patients not previously treated for …

Bankstown-Lidcombe Hospital
 (9.9 away) Contact site
  • 31 views
  • 01 Nov, 2020
  • +234 other locations
Safety Tolerability and Efficacy of Cilofexor in Non-Cirrhotic Adults With Primary Sclerosing Cholangitis

The primary objective of this study is to evaluate whether cilofexor reduces the risk of fibrosis progression among non-cirrhotic adults with primary sclerosing cholangitis (PSC).

fibrosis
platelet count
cilofexor
Royal Prince Alfred Hospital
 (7.3 away) Contact site
  • 83 views
  • 25 Nov, 2020
  • +217 other locations
Comparison of Ridinilazole Versus Vancomycin Treatment for Clostridium Difficile Infection

Summit is developing ridinilazole as a novel antimicrobial for Clostridium difficile Infection (CDI) with the goal of achieving comparable cure rates to standard of care, but reducing rates of recurrent disease. A phase 2 proof of concept study, with vancomycin as comparator, demonstrated these attributes with a comparable safety profile. …

diarrhea
clostridium difficile
antibiotics
ridinilazole
vancomycin
Westmead Hospital
 (7.9 away) Contact site
  • 101 views
  • 08 Jul, 2020
  • +223 other locations
A Phase 3 Multi-Center Randomized Double-Blind Placebo-Controlled Study of Fostamatinib Disodium in the Treatment of wAIHA

The primary objective of this study is to assess the efficacy of fostamatinib in subjects with warm antibody autoimmune hemolytic anemia (wAIHA).

Concord Repatriation General Hospital
 (7.3 away) Contact site
  • 113 views
  • 26 Oct, 2020
  • +105 other locations
A Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer

A phase III multi-center, randomized, open-label trial to evaluate efficacy and safety of ribociclib with endocrine therapy as adjuvant treatment in patients with HR+/HER2- Early Breast Cancer

Novartis Investigative Site
 (0.1 away) Contact site
  • 211 views
  • 25 Oct, 2020
  • +343 other locations
Efficacy Safety and Tolerability of Atogepant for the Prevention of Chronic Migraine

This study will evaluate the efficacy, safety and tolerability of atogepant in participants with chronic migraine. This study includes a 12-week treatment period.

migraine
headache
Royal North Shore Hospital
 (4.8 away) Contact site
  • 576 views
  • 01 Nov, 2020
  • +146 other locations
Adding Mitomycin C to Bacillus of Calmette-Guerin (BCG) as Adjuvant Intravesical Therapy for High-risk Non-Muscle-invasive Bladder Cancer

Open label, randomised phase 3 trial of the addition of Mitomycin C to BCG as adjuvant intravesical therapy for high-risk, non-muscle-invasive bladder cancer. The study aim is to compare disease-free survival between treatment arms: BCG alone versus Mitomyicn C in addition to BCG.

invasive bladder cancer
carcinoma
carcinoma in situ
cancer
transurethral resection
Concord Repatriation General Hospital
 (3.5 away) Contact site
  • 16 views
  • 08 Nov, 2020
  • 1 location
Defining the Clinical Role of Topiramate in the Treatment of Alcohol Dependence in Australia

To compare the clinical effectiveness, tolerability, and cost-effectiveness of topiramate to active control (naltrexone) on treatment outcomes for alcohol dependence in a double-blind randomised controlled trial.

naltrexone
topiramate
heavy drinking
alcoholism
alcohol use disorder
Drug Health Services, Royal Prince Alfred Hospital
 (7.5 away) Contact site
  • 293 views
  • 08 Nov, 2020
  • 1 location
PAEAN - Erythropoietin for Hypoxic Ischaemic Encephalopathy in Newborns

Double-blind, placebo controlled Phase III trial of erythropoietin for hypoxic ischaemic encephalopathy in infants receiving hypothermia. The study aim is to determine whether Epo in conjunction with hypothermia in infants with moderate/severe hypoxic ischaemic encephalopathy (HIE) will improve neurodevelopmental outcomes at 2 years of age, without significant adverse effects, when …

encephalopathy
deficit
hypothermia
severe hypoxic-ischemic encephalopathy
continuous positive airway pressure
Royal North Shore Hospital
 (4.8 away) Contact site
  • 72 views
  • 14 Jul, 2019
  • +24 other locations