North Ryde, Australia Clinical Trials

A listing of North Ryde, Australia clinical trials actively recruiting patients volunteers.

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Found 127 clinical trials
Phase II Study to Assess AFM13 in Patients With R/R CD30-positive T-cell Lymphoma or Transformed Mycosis Fungoides

This is a phase II study to evaluate the antitumor activity and safety of AFM13 given as monotherapy in patients with CD30-positive T-cell lymphoma. The investigational medicinal product AFM13 is a tetravalent bispecific chimeric (anti-human CD30 x anti-human CD16A) recombinant antibody construct which is being developed to treat CD30-positive malignancies. …

fungal infection
t-cell lymphoma
brentuximab
mycosis fungoides
brentuximab vedotin
Concord Repatriation General Hospital
 (4.4 away) Contact site
  • 32 views
  • 30 Jul, 2021
  • +83 other locations
Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE)

The purpose of this study is to determine if Rozibafusp Alfa could be a useful therapeutic agent in the current treatment landscape where subjects with systemic lupus erythematosus (SLE) have ongoing disease activity despite treatment with standard of care therapies.

mouth ulcer
mycophenolate
lupus
pericarditis
chloroquine
Research Site
 (7.3 away) Contact site
  • 44 views
  • 23 Jun, 2021
  • +230 other locations
Study Evaluating Cemiplimab Alone and Combined With RP1 in Treating Advanced Squamous Skin Cancer

To estimate the clinical benefit of cemiplimab monotherapy versus cemiplimab in combination with RP1 for patients with locally advanced or metastatic CSCC, as assessed by overall response rate (ORR) and complete response rate (CRR) according to blinded independent review.

cemiplimab
cancer
skin cancer
Chris O'Brien Lifehouse
 (7.3 away) Contact site
  • 2 views
  • 07 Jul, 2021
  • +38 other locations
Letermovir Treatment in Pediatric Participants Following Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) (MK-8228-030)

The primary objective of this study is to evaluate the pharmacokinetics (PK) of letermovir (LET) in pediatric participants. Participants will be enrolled in the following 3 age groups: Age Group 1: From 12 to <18 years of age (adolescents); Age Group 2: From 2 to <12 years of age (children); …

Westmead Hospital ( Site 0185)
 (7.7 away) Contact site
  • 19 views
  • 26 Jun, 2021
  • +39 other locations
Evaluate F901318 Treatment of Invasive Fungal Infections in Patients Lacking Treatment Options

A study to evaluate F901318 (study drug) for the treatment of invasive fungal infections in patients lacking suitable alternative treatment options.

fungal infection
Westmead Hospital
 (7.9 away) Contact site
  • 291 views
  • 17 Feb, 2021
  • +78 other locations
Safety and Efficacy of Tipifarnib in Head and Neck Cancer With HRAS Mutations and Impact of HRAS on Response to Therapy

An international, multicenter, open-label, 2 cohort, non-comparative, pivotal study evaluating the efficacy of tipifarnib in HRAS mutant HNSCC (AIM-HN). The first cohort will assess the objective response rate (ORR) of tipifarnib in subjects with HNSCC with HRAS mutations. The second study cohort, SEQ-HN, is an observational sub-study and includes 2 …

HRAS
neck cancer
measurable disease
cancer
caries
Royal North Shore Hospital
 (4.8 away) Contact site
  • 3 views
  • 08 Mar, 2021
  • +137 other locations
This Study Tests Whether BI 425809 Together With Brain Training Using a Computer Improves Mental Functioning in Patients With Schizophrenia

This is a study in adults with schizophrenia. The study tests whether a medicine called BI 425809 together with brain training improves mental abilities. Participants take study medication once a day for 12 weeks. At the start of the study, the participants are put into 2 groups. It is decided …

anticholinergics
clozapine
antipsychotics
cognitive training
antidepressants
University of Sydney
 (7.3 away) Contact site
  • 773 views
  • 19 Jul, 2021
  • +59 other locations
GOLDEN STUDY: A Study to Assess Safety and Efficacy of Multiple Doses of IONIS-FB-LRx in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (AMD)

The purpose of the study is to evaluate the effect of IONIS-FB-LRx on the rate of change of the area of geographic atrophy (GA) secondary to age-related macular degeneration (AMD) measured by fundus autofluorescence (FAF).

corrected visual acuity
pneumoniae
age-related macular degeneration
pupillary dilation
geographic atrophy
Marsden Eye Specialists
 (6.8 away) Contact site
  • 515 views
  • 19 Jul, 2021
  • +155 other locations
Tavo and Pembrolizumab in Patients With Stage III/IV Melanoma Progressing on Pembrolizumab or Nivolumab Treatment

Keynote 695 will be a Phase 2 study of intratumoral tavokinogene telseplasmid (tavo; pIL-12) Electroporation (EP) plus IV Pembrolizumab. Eligible patients will be those with pathological diagnosis of unresectable or metastatic melanoma who are progressing or have progressed on pembrolizumab or nivolumab.

Westmead Hospital
 (7.9 away) Contact site
  • 150 views
  • 06 May, 2021
  • +42 other locations
A Study to Evaluate the Efficacy and Safety of CC-90001 in Subjects With Idiopathic Pulmonary Fibrosis

This is a Phase 2, multicenter, multinational, randomized, double-blind, placebo-controlled study evaluating the efficacy, safety, pharmacokinetics (PK), quality of life and exploratory pharmacodynamics (PD) of two treatment doses of CC-90001, 200 mg and 400 mg, compared with placebo, when delivered once daily per os (PO) in subjects with idiopathic pulmonary …

pulmonary fibrosis
walk tests
pulmonary function test
forced vital capacity
fibrosis
Concord Repatriation General Hospital
 (4.8 away) Contact site
  • 1660 views
  • 19 Jul, 2021
  • +104 other locations