North Ryde, Australia Clinical Trials

A listing of North Ryde, Australia clinical trials actively recruiting patients volunteers.

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Found 127 clinical trials
Osteonecrosis of the Hip and Bisphosphonate Treatment

Osteonecrosis of the hip is an important cause of musculoskeletal disability and finding therapeutic solutions has proven to be challenging. Osteonecrosis means death of bone which can occur from the loss of the blood supply or some other means. Although any age group may develop osteonecrosis, most patients are between …

steroid treatment
hypertension
core decompression
arco
bisphosphonate
Royal North Shore Hospital, Department of Rheumatology
 (5.0 away) Contact site
  • 17 views
  • 07 Nov, 2020
  • +4 other locations
A Randomised Phase II Trial of Osimertinib With or Without SRS for EGFR Mutated NSCLC With Brain Metastases

20-40% of patients with NSCLC will develop brain metastases at some point during their course of disease. Osimertinib has demonstrated intracranial activity in EFGR mutated NSCLC with leptomeningeal disease in the phase 1 BLOOM study. Stereotactic radiosurgery (SRS) is one of the standard local treatment for patients with limited number …

Liverpool Hospital
 (7.3 away) Contact site
  • 50 views
  • 15 Mar, 2021
  • +14 other locations
ANAVEX2-73 Study in Patients With Rett Syndrome

ANAVEX2-73 Study in Patients With Rett Syndrome: ANAVEX2-73-RS-002 is a Phase 2, double-blind, randomized, placebo-controlled dose escalation safety, tolerability and efficacy study in patients 18 years and older with RTT using endpoints including multiple clinical and exploratory molecular and biochemical measures.

antiepileptic drugs
treatment regimen
pregnancy testing
seizure
HammondCare
 (4.6 away) Contact site
  • 12 views
  • 05 May, 2021
  • +6 other locations
Non Small Cell Lung Cancer Trial of Durvalumab and Tremelimumab in Advanced Epidermal Growth Factor Receptor (EGFR) Mutant Disease.

The primary purpose of this trial is to evaluate the efficacy and tolerability of durvalumab and tremelimumab with platinum-pemetrexed in patients with metastatic NSCLC (T790+ve or T790M-ve) following progression on EGFR Tyrosine Kinase Inhibitors.. Study population: Individuals may be eligible to enrol in this trial if aged 18 or over …

Bankstown Hospital
 (9.9 away) Contact site
  • 27 views
  • 24 Jan, 2021
  • +15 other locations
Micronised Resveratrol as a Treatment for Friedreich Ataxia

The aim of this study is to assess the efficacy of micronised resveratrol as a treatment for FRDA, in terms of reducing the severity of ataxia symptoms at 24 weeks, through a randomised blinded, placebo controlled crossover trial.

neutrophils
resveratrol
total bilirubin
Royal North Shore Hospital
 (4.8 away) Contact site
  • 196 views
  • 04 Mar, 2021
  • +3 other locations
In Men With Metastatic Prostate Cancer What is the Safety and Benefit of Lutetium-177 PSMA Radionuclide Treatment in Addition to Chemotherapy

This phase 2 randomised clinical trial will compare the effectiveness of Lu-PSMA therapy followed by docetaxel chemotherapy versus docetaxel chemotherapy on its own in patients with newly-diagnosed high-volume metastatic hormone-naive prostate cancer (mHNPC).

St Vincent's Hospital Sydney
 (8.2 away) Contact site
  • 0 views
  • 27 Jan, 2021
  • +4 other locations
Phase 2a Evaluation of Safety Tolerability and Pharmacokinetics of PLN-74809 in Patients With Primary Sclerosing Cholangitis (PSC)

A Phase 2a, multicenter, randomized, double-blind, dose-ranging, placebo-controlled, study to evaluate the safety, tolerability, and PK of PLN-74809 in participants with primary sclerosing cholangitis and suspected liver fibrosis

MRI
endoscopic retrograde cholangiopancreatography
ursodiol
fibrosis
magnetic resonance cholangiopancreatography
Royal Prince Alfred Hospital
 (7.5 away) Contact site
  • 0 views
  • 07 Jun, 2021
  • +31 other locations
Enzalutamide With Lu PSMA-617 Versus Enzalutamide Alone in Men With Metastatic Castration-resistant Prostate Cancer

This phase 2 randomised clinical trial will investigate the activity and safety of adding Lu-PSMA to enzalutamide in patients with metastatic castrate resistant prostate cancer (mCRPC) not previously treated with chemotherapy.

bone metastases
conjugated bilirubin
progressive disease
metastasis
neutrophil count
St Vincents Hospital
 (8.2 away) Contact site
  • 0 views
  • 16 May, 2021
  • +3 other locations
OLE Study for Patients With Parkinson's Disease With Dementia Enrolled in Study ANAVEX2-73-PDD-001

This is a Phase 2 open-label extension study to evaluate the effects of ANAVEX2-73 on safety and efficacy of daily treatment.

KaRa MINDS
 (0.8 away) Contact site
  • 0 views
  • 26 Jan, 2021
  • +4 other locations
A Study Evaluating the Safety Tolerability and Effect on Microvascular Obstruction of Intravenous Temanogrel in Adult Participants Undergoing Percutaneous Coronary Intervention

The purpose of this study is to determine whether intravenous temanogrel is a safe and effective treatment for microvascular obstruction (MVO) in adult participants undergoing percutaneous coronary intervention (PCI).

Concord Repatriation General Hospital
 (3.5 away) Contact site
  • 0 views
  • 08 Jul, 2021
  • 1 location